Protein Overview: SNF8

General Information:
Name(s) found:	SNF8 / YPL002C [SGD]
Description(s) found: Found 38 descriptions. SHOW ALL	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression [SGD]
Organism:	Saccharomyces cerevisiae
Length:	233 amino acids
Gene Ontology:
Cellular Component:	ESCRT II complex [IDA]
Biological Process:	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IC] telomere maintenance [IMP ] negative regulation of transcription from RNA polymerase II promoter by glucose [IMP] protein targeting to vacuole [IMP][IPI]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQFGLAAFD ELKDGKYNDV NKTILEKQSV ELRDQLMVFQ ERLVEFAKKH NSELQASPEF  60
   61 RSKFMHMCSS IGIDPLSLFD RDKHLFTVND FYYEVCLKVI EICRQTKDMN GGVISFQELE 120
  121 KVHFRKLNVG LDDLEKSIDM LKSLECFEIF QIRGKKFLRS VPNELTSDQT KILEICSILG 180
  181 YSSISLLKAN LGWEAVRSKS ALDEMVANGL LWIDYQGGAE ALYWDPSWIT RQL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		SNF8 VPS36
View Details	Krogan NJ, et al. (2006)		ADH7 HCM1 OLA1 SNF8 VPS25 VPS36
View Details	Qiu et al. (2008)		SNF7 SNF8 SRN2 STP22 VPS25 VPS36

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CTF13	SNF8	1	Unpublished Fields Lab Data
View Screen	YPR097W	SNF8	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SNF8	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..233]	MSA	3.012982	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	5.08959163553491	bayes_pls_golite062009
nucleic acid binding	4.99681957904233	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
transcription repressor activity	3.85678231380989	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
sequence-specific DNA binding	2.48053910222825	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.2723726467408	bayes_pls_golite062009
specific transcriptional repressor activity	0.96257232341735	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
protein binding	0.753698599635855	bayes_pls_golite062009
structure-specific DNA binding	0.750801486608713	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
signal transducer activity	0.574575108509588	bayes_pls_golite062009
molecular transducer activity	0.574575108509588	bayes_pls_golite062009
transcription corepressor activity	0.322180400748724	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.23177057841536	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.136726704233672	bayes_pls_golite062009
small conjugating protein ligase activity	0.118016217031359	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2