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Protein Overview: STP22

General Information:
Name(s) found: STP22 / YCL008C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article][IPILink to PubMed article]
    ESCRT I complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    protein targeting to membrane [IMPLink to PubMed article][IPILink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNALDLMD MDNTDISPTN HHEMLQNLQT VVNELYREDV 240
  241 DYVADKILTR QTVMQESIAR FHEIIAIDKN HLRAVEQAIE QTMHSLNAQI DVLTANRAKV 300
  301 QQFSSTSHVD DEDVNSIAVA KTDGLNQLYN LVAQDYALTD TIECLSRMLH RGTIPLDTFV 360
  361 KQGRELARQQ FLVRWHIQRI TSPLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MVB12 SRN2 STP22
    View Details Krogan NJ, et al. (2006) MVB12 SRN2 STP22 VPS28
    View Details Qiu et al. (2008) SNF8 SRN2 STP22 VPS28

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] PSI-BLAST 35.69897 A complex of the Vps23 UEV with ubiquitin
    2 View Details [234..385] MSA 5.119985 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  5.39546375801135 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  5.24355531841986 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.3569172339832 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.17039194032383 bayes_pls_golite062009
  • ligase activity
    		•  1.88059319399119 bayes_pls_golite062009
  • protein binding
    		•  1.12473783261956 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • binding
    		•  0.7313332818323 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle