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Protein Overview: SRN2

General Information:
Name(s) found: SRN2 / YLR119W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: endosome [IPILink to PubMed article]
    ESCRT I complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    protein targeting to membrane [IMPLink to PubMed article][IPILink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKATKLRI KQRRKNKGLN ISRLDIIRAE MDVVPSPGLP EKVNEKSKNI PLPEGINLLS  60
   61 SKEIIDLIQT HRHQLELYVT KFNPLTDFAG KIHAFRDQFK QLEENFEDLH EQKDKVQALL 120
  121 ENCRILESKY VASWQDYHSE FSKKYGDIAL KKKLEQNTKK LDEESSQLET TTRSIDSADD 180
  181 LDQFIKNYLD IRTQYHLRRE KLATWDKQGN LKY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MVB12 RIM8 SRN2 STP22
    View Details Krogan NJ, et al. (2006) MVB12 SRN2 STP22 VPS28
    View Details Qiu et al. (2008) DID4 MVB12 SNF7 SNF8 SRN2 STP22 VPS20 VPS24 VPS28

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle