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Protein Overview: VPS24

General Information:
Name(s) found: VPS24 / YKL041W [SGD]
Description(s) found:
Found 27 descriptions.
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  • One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: ESCRT III complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    late endosome to vacuole transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYIKKAIWG PDPKEQQRRI RSVLRKNGRN IEKSLRELTV LQNKTQQLIK KSAKKNDVRT  60
   61 VRLYAKELYQ INKQYDRMYT SRAQLDSVRM KIDEAIRMNT LSNQMADSAG LMREVNSLVR 120
  121 LPQLRNTMIE LEKELMKSGI ISEMVDDTME SVGDVGEEMD EAVDEEVNKI VEQYTNEKFK 180
  181 NVDQVPTVEL AANEEEQEIP DEKVDEEADR MVNEMRERLR ALQN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) SNF7 VPS24 VPS4
    View Details Krogan NJ, et al. (2006) SNF7 VPS24
    View Details Qiu et al. (2008) DID4 SNF7 SRN2 VPS20 VPS24 VPS25 VPS28

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS24 Huh WK, et al. (2003)
    View Data VPS24 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] ORFEUS 8.2 Apolipoprotein A-I


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle