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Protein Overview: MTR10

General Information:
Name(s) found: MTR10 / YOR160W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 972 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: RNA import into nucleus [IMPLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    RNA localization [IMPLink to PubMed article]
    Molecular Function: nuclear localization sequence binding [IPILink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS KEDPTNALLE  60
   61 LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ KLIITQLNVA LARLAIQFLE 120
  121 WQNPIFEIIS LLNSSPSILL NFLRILPEET LDIASTSLTE VEFNSRIHEL IDPIAEDVLK 180
  181 FLVSCIDLLQ NTDGNSSSSI SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE 240
  241 SDMEAFDSAI DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD 300
  301 LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT FPFWFNFKQS 360
  361 LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE EDKFKDFRYH MGDVLKDCTA 420
  421 VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA PLFSLRTMAK EISLTENTIL PEIIKIICNL 480
  481 PEQAKIRYAS TLVLGRYTEW TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM 540
  541 FFCSDCSKLL VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV 600
  601 DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS EPLLPRIEFI 660
  661 WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP ILPSVAEFLI QGYLTTGFGS 720
  721 YLWCSGSLIV IFGDDESFPI SPSLKDAVWK FALSQCETFI LNFNKFDKLQ LNDYHEAIID 780
  781 FFSLISDLIM FYPGAFLNST ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT 840
  841 PPISTVSIEI VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR 900
  901 ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK VREGIRAFVG 960
  961 WYSRKNINSR FE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) ATG3 MTR10 NMD5 USA1
    View Details Gavin AC, et al. (2002) ATG3 MTR10 SIN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MTR10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..642] MSA 13.150996 View MSA. No confident structure predictions are available.
    2 View Details [643..972] MSA 1.118943 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • transporter activity
    		•  2.92319684675174 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • RNA binding
    		•  2.62683106046883 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  2.13470398426489 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90912542848632 bayes_pls_golite062009
  • DNA binding
    		•  1.77040152722002 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65364344577652 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.6217303285315 bayes_pls_golite062009
  • transcription factor activity
    		•  1.27944481949335 bayes_pls_golite062009
  • mRNA binding
    		•  1.24616647164637 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.20870827474803 bayes_pls_golite062009
  • structural molecule activity
    		•  0.908029258648777 bayes_pls_golite062009
  • RNA cap binding
    		•  0.85485270555676 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0797305392056347 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • transcription factor binding
    		•  0.00210118982863072 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle