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Protein Overview: AUS1

General Information:
Name(s) found: AUS1 / YOR011W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1394 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    membrane [ISSLink to PubMed article]
    Biological Process: sterol transport [IMPLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of substances [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISKYFTPV ADGSLTFNGA NIQFGADAQG ESKKSYDAED SMPNPANQLN DITFQAEAGE  60
   61 MVLVLGYPTS TLFKTLFHGK TSLSYSPPGS IKFKNNEFKS FSEKCPHQII YNNEQDVHFP 120
  121 FLTVEQTIDF ALSCKFDIPK GERDQIRNEL LREFGLSHVL KTIVGNDFFR GVSGGERKRI 180
  181 SIIETFIANG SVYLWDNSTK GLDSATALDF LEILRKMAKA TRSVNLVRIS QASDKIVDKF 240
  241 DKILMLSDSY QLFYGTVDEC LTYFRDTLGI EKDPNDCIIE YLTSILNFQF KNKNLGNLSN 300
  301 SSSASVLKTA TGEVTKYTYN SDFDLYDQWK HSSYYRNIKQ QIQGSSIDDS IKEVDPSDVS 360
  361 PIFNIPLKKQ LLFCTKRAFQ RSLGDKAYMT AQFISVVIQS LVIGSLFYEI PLTTIGSYSR 420
  421 GSLTFFSILF FTFLSLADMP IAFQRQPVVK KQSQLHFYTN WVETLSTTVF DYCFKLCLVI 480
  481 VFSIILYFLA HLQYKAARFF IFLLFLSFYN FCMVSLFALT TLVAPTISVA NLFAGILLLA 540
  541 IAMYASYVIY LKNMHPWFVW IAYLNPAMYA MEAILSNELY NLKLDCSETI VPRGPTYNDV 600
  601 PFSHKACAWQ GATLGNDYVR GRDYLKQGLS YTYHHVWRNF GIIIGFLVFF IACTLFASQY 660
  661 IKPYFNKDEI ERNNSRLTRW LPFLNKKRGT RSSARNDSKY VGIPKSHSVS SSSSSLSAVP 720
  721 YQISPSNKEM ALNDYNEQPI TETVETQKHI ISWKNINYTV GTKKLINNAS GFISSGLTAL 780
  781 MGESGAGKTT LLNVLSQRVE TGVVSGEILI DGHPLTDEDA FKRSIGFVQQ QDLHLDLLSV 840
  841 KESLEISCLL RGDGDRAYLD TVSNLLKLPS DILVADLNPT QRKLLSIGVE LVTKPSLLLF 900
  901 LDEPTSGLDA EAALTIVKFL KQLSLQGQAI FCTIHQPSKS VISHFDNIFL LKRGGECVFF 960
  961 GPMDDACGYF MSHDNTLVYD KEHDNPADFV IDAVGNSNSS AGKDTAEEAL TLNKEAIDWS1020
 1021 ALWESSVEKK LVKKETARLE DDARASGVDY TTSLWKQPSY LQQLALITRR QYICTKRDMT1080
 1081 YVMAKYCLNG GAGLFIGFSF WHIKHNIIGL QDSIFFCFMA LCVSSPLINQ IQDKALKTKE1140
 1141 VYVAREARSN TYHWTVLLLS QSIIELPLAL TSSTLFFVCA FFSCGFNNAG WSAGVFFLNY1200
 1201 MLFAAYYSTL GLWLIYTAPN LQTAAVFVAF IYSFTASFCG VMQPYSLFPT FWKFMYRVSP1260
 1261 YTYFVETFVS ILLHNWEIKC DMSEMVPGQP LTGQSCGQFM EAFIEEYGGY LHNKNTFTVC1320
 1321 AYCTYTVGDD FLKNENMSYD HVWRNFGIEW AFVGFNFFAM FAGYYLTYVA RIWPKVFKII1380
 1381 TKVIPHRGKK PVQN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..360] PSI-BLAST 120.9794 Maltose transport protein MalK, C-terminal domain; Maltose transport protein MalK, N-terminal domain
    2 View Details [361..584] MSA 1.228963 View MSA. No confident structure predictions are available.
    3 View Details [585..737] deduced N/A No confident structure predictions are available.
    4 View Details [738..984] Pfam 24.920819 ABC transporter No confident structure predictions are available.
    5 View Details [985..1289] MSA 3.418955 View MSA. No confident structure predictions are available.
    6 View Details [1290..1394] deduced N/A No confident structure predictions are available.
    7 View Details [1282..1394] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  6.58863529263644 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  6.58067278719409 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  6.57974651657836 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  6.57922174989907 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  6.57807080367604 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  6.48406410175216 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  6.48154954364331 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  6.40467109535527 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  6.40151534181487 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  6.38373914253885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  6.38247436082206 bayes_pls_golite062009
  • ATPase activity
    		•  6.30019941712404 bayes_pls_golite062009
  • hydrolase activity
    		•  4.60957912556603 bayes_pls_golite062009
  • sterol transporter activity
    		•  4.45355165759136 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  3.40690615950081 bayes_pls_golite062009
  • ribonucleotide binding
    		•  3.40594996232845 bayes_pls_golite062009
  • purine nucleotide binding
    		•  3.3669118613715 bayes_pls_golite062009
  • nucleotide binding
    		•  3.33248266870364 bayes_pls_golite062009
  • ATP binding
    		•  3.17398570826788 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.14635082108971 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  3.12628113185041 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  3.0710107594224 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  2.88795687640992 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  2.72457626066894 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.50934147358924 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.26176677225712 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  2.15656963765495 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  2.15656963765495 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • azole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • fluconazole transporter activity
    		•  1.75428613304237 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.23869719200594 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.896078342024449 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA binding
    		•  0.361518668029935 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  0.301752323171649 bayes_pls_golite062009
  • GTPase activity
    		•  0.20164416416912 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • motor activity
    		•  0.14734538548583 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • signal transducer activity
    		•  0.144122328222529 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.133605084599819 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • protein transporter activity
    		•  0.104820191623932 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.0181245554613096 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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