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View Structure Prediction Details

Protein: AUS1
Organism: Saccharomyces cerevisiae
Length: 1394 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AUS1.

Description E-value Query
Range		 Subject
Range
gi|18152891 - gi|18152891|gb|AAK62810.2|AF227914_1 ATP-binding cassette transporter ABC1 [Venturia inaequalis]
 0.0 [22..1382] [176..1517]
CDR4_CANAX - ABC transporter CDR4 OS=Candida albicans GN=CDR4 PE=3 SV=1
 0.0 [2..1371] [114..1480]
PDR11 - ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; ...
gi|151943145 - gi|151943145|gb|EDN61480.1| multidrug transporter [Saccharomyces cerevisiae YJM789]
gi|207344265 - gi|207344265|gb|EDZ71467.1| YIL013Cp-like protein [Saccharomyces cerevisiae AWRI1631]
PDR11_YEAST - ATP-dependent permease PDR11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDR11 PE=1 ...
 0.0 [1..1385] [1..1395]
gi|66826585, gi|... - gi|66826585|ref|XP_646647.1| ABC transporter G family protein [Dictyostelium discoideum AX4], gi|604...
ABCGJ_DICDI - ABC transporter G family member 19 OS=Dictyostelium discoideum GN=abcG19 PE=3 SV=1
 0.0 [8..1372] [96..1449]
gi|6175524 - gi|6175524|gb|AAF05069.1|AF109723_1 ATP-binding cassette transporter [Candida glabrata]
 0.0 [2..1382] [103..1499]
gi|14278974 - gi|14278974|dbj|BAB59028.1| ABC transporter PMR5 [Penicillium digitatum]
 0.0 [11..1380] [62..1413]

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Predicted Domain #1
Region A:
Residues: [1-360] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISKYFTPV ADGSLTFNGA NIQFGADAQG ESKKSYDAED SMPNPANQLN DITFQAEAGE  60
   61 MVLVLGYPTS TLFKTLFHGK TSLSYSPPGS IKFKNNEFKS FSEKCPHQII YNNEQDVHFP 120
  121 FLTVEQTIDF ALSCKFDIPK GERDQIRNEL LREFGLSHVL KTIVGNDFFR GVSGGERKRI 180
  181 SIIETFIANG SVYLWDNSTK GLDSATALDF LEILRKMAKA TRSVNLVRIS QASDKIVDKF 240
  241 DKILMLSDSY QLFYGTVDEC LTYFRDTLGI EKDPNDCIIE YLTSILNFQF KNKNLGNLSN 300
  301 SSSASVLKTA TGEVTKYTYN SDFDLYDQWK HSSYYRNIKQ QIQGSSIDDS IKEVDPSDVS 360
  361

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 120.9794
Match: 1g291_
Description: Maltose transport protein MalK, C-terminal domain; Maltose transport protein MalK, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [361-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIFNIPLKKQ LLFCTKRAFQ RSLGDKAYMT AQFISVVIQS LVIGSLFYEI PLTTIGSYSR  60
   61 GSLTFFSILF FTFLSLADMP IAFQRQPVVK KQSQLHFYTN WVETLSTTVF DYCFKLCLVI 120
  121 VFSIILYFLA HLQYKAARFF IFLLFLSFYN FCMVSLFALT TLVAPTISVA NLFAGILLLA 180
  181 IAMYASYVIY LKNMHPWFVW IAYLNPAMYA MEAILSNELY NLKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [585-737] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCSETIVPRG PTYNDVPFSH KACAWQGATL GNDYVRGRDY LKQGLSYTYH HVWRNFGIII  60
   61 GFLVFFIACT LFASQYIKPY FNKDEIERNN SRLTRWLPFL NKKRGTRSSA RNDSKYVGIP 120
  121 KSHSVSSSSS SLSAVPYQIS PSNKEMALND YNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [738-984] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPITETVETQ KHIISWKNIN YTVGTKKLIN NASGFISSGL TALMGESGAG KTTLLNVLSQ  60
   61 RVETGVVSGE ILIDGHPLTD EDAFKRSIGF VQQQDLHLDL LSVKESLEIS CLLRGDGDRA 120
  121 YLDTVSNLLK LPSDILVADL NPTQRKLLSI GVELVTKPSL LLFLDEPTSG LDAEAALTIV 180
  181 KFLKQLSLQG QAIFCTIHQP SKSVISHFDN IFLLKRGGEC VFFGPMDDAC GYFMSHDNTL 240
  241 VYDKEHD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 24.920819
Match: PF00005
Description: ABC transporter

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [985-1289] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPADFVIDAV GNSNSSAGKD TAEEALTLNK EAIDWSALWE SSVEKKLVKK ETARLEDDAR  60
   61 ASGVDYTTSL WKQPSYLQQL ALITRRQYIC TKRDMTYVMA KYCLNGGAGL FIGFSFWHIK 120
  121 HNIIGLQDSI FFCFMALCVS SPLINQIQDK ALKTKEVYVA REARSNTYHW TVLLLSQSII 180
  181 ELPLALTSST LFFVCAFFSC GFNNAGWSAG VFFLNYMLFA AYYSTLGLWL IYTAPNLQTA 240
  241 AVFVAFIYSF TASFCGVMQP YSLFPTFWKF MYRVSPYTYF VETFVSILLH NWEIKCDMSE 300
  301 MVPGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
sterol transporter activity 4.45355165759136 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
lipid transporter activity 3.14635082108971 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
cholesterol transporter activity 2.72457626066894 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.50934147358924 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
amine-transporting ATPase activity 2.26176677225712 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
signal recognition particle binding 1.23869719200594 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
nucleic acid binding 0.896078342024449 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA binding 0.361518668029935 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 0.301752323171649 bayes_pls_golite062009
GTPase activity 0.20164416416912 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
motor activity 0.14734538548583 bayes_pls_golite062009
molecular transducer activity 0.144122328222529 bayes_pls_golite062009
signal transducer activity 0.144122328222529 bayes_pls_golite062009
transcription regulator activity 0.133605084599819 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
protein transporter activity 0.104820191623932 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
ribonucleoprotein binding 0.0181245554613096 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1290-1394] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTGQSCGQF MEAFIEEYGG YLHNKNTFTV CAYCTYTVGD DFLKNENMSY DHVWRNFGIE  60
   61 WAFVGFNFFA MFAGYYLTYV ARIWPKVFKI ITKVIPHRGK KPVQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1282-1394] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEMVPGQPL TGQSCGQFME AFIEEYGGYL HNKNTFTVCA YCTYTVGDDF LKNENMSYDH  60
   61 VWRNFGIEWA FVGFNFFAMF AGYYLTYVAR IWPKVFKIIT KVIPHRGKKP VQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle