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Protein Overview: RAD14

General Information:
Name(s) found: RAD14 / YMR201C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 371 amino acids

    Gene Ontology:
    Cellular Component: nucleotide-excision repair factor 1 complex [IPILink to PubMed article][TASLink to PubMed article]
    nucleus [IDALink to PubMed article]
    Biological Process: nucleotide-excision repair, DNA damage recognition [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: zinc ion binding [IDALink to PubMed article]
    damaged DNA binding [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPEQKAKLE ANRKLAIERL RKRGILSSDQ LNRIESRNEP LKTRPLAVTS GSNRDDNAAA  60
   61 AVHVPNHNGQ PSALANTNTN TTSLYGSGVV DGSKRDASVL DKRPTDRIRP SIRKQDYIEY 120
  121 DFATMQNLNG GYINPKDKLP NSDFTDDQEF ESEFGSKKQK TLQDWKKEQL ERKMLYENAP 180
  181 PPEHISKAPK CIECHINIEM DPVLHDVFKL QVCKQCSKEH PEKYALLTKT ECKEDYFLTD 240
  241 PELNDEDLFH RLEKPNPHSG TFARMQLFVR CEVEAFAFKK WGGEEGLDEE WQRREEGKAH 300
  301 RREKKYEKKI KEMRLKTRAQ EYTNRLREKK HGKAHIHHFS DPVDGGIDED GYQIQRRRCT 360
  361 DCGLETEEID I

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) RAD1 RAD10 RAD14
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Ho Y, et al. (2002) CCE1 CTF4 RAD1 RAD14 RAD16 RAD4
    View Details Qiu et al. (2008) ABF1 ELC1 RAD1 RAD10 RAD14 RAD16 RAD23 RAD4 RAD7 SSL1 TFB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RAD14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] Pfam 43.958607 XPA protein N-terminal No confident structure predictions are available.
    2 View Details [187..371] PSI-BLAST 135.30103 DNA repair factor XPA DNA- and RPA-binding domain, C-terminal subdomain; DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.81621967469952 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.20400142735918 bayes_pls_golite062009
  • DNA binding
    		•  2.18702281581791 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.04270847321412 bayes_pls_golite062009
  • protein binding
    		•  1.60194768638501 bayes_pls_golite062009
  • transcription factor activity
    		•  1.44182975349714 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.71242082351425 bayes_pls_golite062009
  • transcription activator activity
    		•  0.612819891085 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.610805977602876 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.51536225088963 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.44426709732278 bayes_pls_golite062009
  • transcription factor binding
    		•  0.40850395411512 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.280685154942276 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0268930241866703 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle