Protein Overview: CTF18

General Information:
Name(s) found:	CTF18 / YMR078C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|807960\|emb\|CAA89224.1\| Chl12p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323724\|ref\|NP_013795.1\| Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; Ctf18p [Sac [NCBI NR] gi\|1705792\|sp\|P49956.1\|CTF18_YEAST RecName: Full=Chromosome transmission fidelity protein 18 [NCBI NR] pir\|\|S50340 CHL12 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Chromosome transmission fidelity protein 18 OS=Saccharomyces cerevisiae GN=CTF18 PE=1 SV=1 [Swiss-Prot] (P49956) Protein CHL12 [Swiss-Prot] (P49956) CHL12 protein [Swiss-Prot] CTF18 Protein required for accurate chromosome transmission in mitosis and maintenance of normal telomere length [mips] Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint [SGD] CTF18, Chr XIII from 422502-424727, reverse complement [yeast_orfs2] Chr XIII from 422502-424727, reverse complement [yeastorf3.fasta] Chr XIII from 424727-422502, reverse complement [yeastorf5.fasta] CTF18 SGDID:S0004683, Chr XIII from 424727-422502, reverse complement, Verified ORF [yeastflysequest.fasta] Ctf18p [Saccharomyces cerevisiae]gi\|807960\|emb\|CAA89224.1\| Chl12p [Saccharomyces cerevisiae]gi\|1084530\|pir\|\|S50340 CHL12 protein - yeast (Saccharomyces cerevisiae)gi\|1705792\|sp\|P49956\|CH12_YEAST CHL12 protein [nrdb_11152004_Chlamydomonas] CTF18 SGDID:S000004683, Chr XIII from 424727-422502, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; Ctf18p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Chl12p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Chromosome transmission fidelity protein 18 [nr-271106-contam.fasta] CTF18 SGDID:S000004683, Chr XIII from 424727-422502, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Chromosome transmission fidelity protein 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTF18 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CTF18 SGDID:S000004683, Chr XIII from 424728-422503, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" [yeast-030211-contam.fasta] CTF18 SGDID:S000004683, Chr XIII from 424728-422503, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" [20141208_orf_trans.fasta] YMR078C SGDID:S000004683, Chr XIII from 424728-422503, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	741 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] DNA replication factor C complex [IPI]
Biological Process:	mitotic sister chromatid cohesion [IMP ]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDTAPYIGS LGRSSLFDTG DIEQAPGNNA IGINEEDIHA FVSSTGETVQ LKKKPAKLAT  60
   61 GNISLYTNPD TVWRSDDTYG ININYLLDKI EASGDDRTNA QKTSPITGKI GSDTLWVEKW 120
  121 RPKKFLDLVG NEKTNRRMLG WLRQWTPAVF KEQLPKLPTE KEVSDMELDP LKRPPKKILL 180
  181 LHGPPGIGKT SVAHVIAKQS GFSVSEINAS DERAGPMVKE KIYNLLFNHT FDTNPVCLVA 240
  241 DEIDGSIESG FIRILVDIMQ SDIKATNKLL YGQPDKKDKK RKKKRSKLLT RPIICICNNL 300
  301 YAPSLEKLKP FCEIIAVKRP SDTTLLERLN LICHKENMNI PIKAINDLID LAQGDVRNCI 360
  361 NNLQFLASNV DSRDSSASDK PACAKNTWAS SNKDSPISWF KIVNQLFRKD PHRDIKEQFY 420
  421 ELLNQVELNG NSDRILQGCF NIFPYVKYSD NGIRKPANIS DWLFFHDLMY QSMYAHNGEL 480
  481 LRYSALVPLV FFQTFGDIAN KDDIRMKNSE YEQRELKRAN SDIVSLIMRH ISVQSPLMAS 540
  541 FTDRKSLIFE ILPYLDSMIS SDFNKIRNLK LKQAIMEELV QLLKSFQLNL IQNRSEGFDV 600
  601 RGGLTIDPPI DEVVLLNPKH INEVQHKRAN NLSSLLAKIE ENRAKKRHID QVTEDRLQSQ 660
  661 EMHSKKVKTG LNSSSSTIDF FKNQYGLLKQ TQELEETQKT IGSDETNQAD DCNQTVKIWV 720
  721 KYNEGFSNAV RKNVTWNNLW E

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CTF18 CTF8
View Details	Krogan NJ, et al. (2006)		AQR1 CTF18 CTF8 DCC1
View Details	Gavin AC, et al. (2002)		CTF18 CTF8 DPB2 ELG1 OLA1 POL2 RFC1 RFC2 RFC3 RFC4 RFC5 TOP2 VPS13 YMR181C
View Details	Qiu et al. (2008)		CTF18 DCC1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YBR190W	CTF18	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CTF18	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..122]	PSI-BLAST	104.165202	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
2	View Details	[123..319]	PSI-BLAST	104.165202	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
3	View Details	[320..441]	PSI-BLAST	104.165202	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
4	View Details	[442..654]	MSA	1.333991	View MSA. No confident structure predictions are available.
5	View Details	[655..741]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2