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Protein Overview: ARC18

General Information:
Name(s) found: ARC18 / YLR370C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 178 amino acids

    Gene Ontology:
    Cellular Component: Arp2/3 protein complex [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [TASLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAYHSTFPV DPNTDRMVGN FALLPLNTKF RGPAYPSNSD YDIIDECLDL FRANSFFKNF  60
   61 EIKSPADRVL IYGILFINDC LAHLKITTSF NEAVKVLTNV ALDNFTLPGT PGFPLNNVYQ 120
  121 VPVQDHNSMD LLKTYIQQFR QELAMRLLER VYSSTDSKEY PSKFWLAFTR RRFMNKSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
    View Details (MIPS) Mewes HW, et al. (2004) ARC15 ARC18 ARC19 ARC35 ARP2 ARP3
    View Details Krogan NJ, et al. (2006) ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 PAC1 TAP42
    View Details Gavin AC, et al. (2006) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
    View Details Gavin AC, et al. (2002) ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 CCT5 CCT8 NOG2 PFK1 PRT1
    View Details Ho Y, et al. (2002) ADR1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATP3 BNI1 DUR1,2 FET3 GFA1 IMH1 KAP122 MCM4 MCM7 MET18 NIP1 NOP4 POB3 PST2 PUF3 RPN8 RPT4 RVB1 SSZ1 TRP3 YJR029W YLR241W YNL040W
    View Details Qiu et al. (2008) ARC15 ARC18 ARC19 ARP2 ARP3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DOT1 ARC18 1 Unpublished Fields Lab Data
    View Screen NIT2 ARC18 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARC18 and SAC6 Huh WK, et al. (2003)
    View Data ARC18 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] PSI-BLAST 488.68867 Arp2/3 complex 21 kDa subunit ARPC3
    2 View Details [72..178] PSI-BLAST 488.68867 Arp2/3 complex 21 kDa subunit ARPC3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  5.63989846641024 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  4.21664682046338 bayes_pls_golite062009
  • actin filament binding
    		•  3.53574857524507 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.90019731783322 bayes_pls_golite062009
  • binding
    		•  1.94576284584165 bayes_pls_golite062009
  • protein binding
    		•  0.756249220099259 bayes_pls_golite062009
  • structural molecule activity
    		•  0.662672430262145 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle