YRC Public Data Repository - Protein Structure Prediction

Protein:	ARC18
Organism:	Saccharomyces cerevisiae
Length:	178 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARC18.

Description	E-value	Query Range	Subject Range
gi\|73994595 - gi\|73994595\|ref\|XP_534672.2\| PREDICTED: similar to Actin-related protein 2/3 complex subunit 3 (ARP2... gi\|195562227, gi... - gi\|195562227\|gb\|ACG50183.1\| actin related protein 2/3 complex subunit 3 [Sus scrofa], gi\|194042944\|r... gi\|109098698 - gi\|109098698\|ref\|XP_001107191.1\| PREDICTED: actin related protein 2/3 complex, subunit 3, 21kDa isof... ARPC3_BOVIN - Actin-related protein 2/3 complex subunit 3 OS=Bos taurus GN=ARPC3 PE=1 SV=3 ARPC3 - actin related protein 2/3 complex, subunit 3, 21kDa gi\|149720678 - gi\|149720678\|ref\|XP_001495332.1\| PREDICTED: similar to Actin-related protein 2/3 complex subunit 3 (... gi\|114576474 - gi\|114576474\|ref\|XP_001147520.1\| PREDICTED: similar to p21-Arc isoform 2 [Pan troglodytes] ENSCJAT000000440... - null, null	6.0E-81	[1..178]	[1..173]
ARPC3_MOUSE - Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3	2.0E-80	[1..178]	[1..173]
ARC18 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin pa... gi\|190405414 - gi\|190405414\|gb\|EDV08681.1\| ARP2/3 complex 21 kDa subunit [Saccharomyces cerevisiae RM11-1a] ARPC3_YEAST - Actin-related protein 2/3 complex subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... gi\|151940893 - gi\|151940893\|gb\|EDN59275.1\| arp2/3 complex subunit [Saccharomyces cerevisiae YJM789]	6.0E-73	[1..178]	[1..178]
gi\|220950296, gi... - gi\|220959246\|gb\|ACL92166.1\| Arpc3B-PA [synthetic construct], gi\|220950296\|gb\|ACL87691.1\| Arpc3B-PA [... Arpc3B-PA - The gene Arpc3B is referred to in FlyBase by the symbol Dmel\Arpc3B (CG8936, FBgn0065032). It is a p...	9.0E-71	[1..178]	[1..169]
ARPC3_SCHPO - Actin-related protein 2/3 complex subunit 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... arc3 - ARP2 /3 actin-organizing complex subunit Arc21	2.0E-69	[1..178]	[1..174]
ARPC3_ARATH - Actin-related protein 2/3 complex subunit 3 OS=Arabidopsis thaliana GN=ARPC3 PE=1 SV=1	5.0E-65	[4..175]	[3..170]
arx-5 - status:Confirmed UniProt:Q9XWV3 protein_id:CAA21538.1	2.0E-62	[1..178]	[1..176]
gi\|66800891, gi\|... - gi\|66800891\|ref\|XP_629371.1\| actin related protein 2/3 complex, subunit 3 [Dictyostelium discoideum ... ARPC3_DICDI - Actin-related protein 2/3 complex subunit 3 OS=Dictyostelium discoideum GN=arcC PE=1 SV=1	3.0E-62	[4..178]	[3..174]

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Predicted Domain #1

Region A:
Residues: [1-71]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAYHSTFPV DPNTDRMVGN FALLPLNTKF RGPAYPSNSD YDIIDECLDL FRANSFFKNF  60
   61 EIKSPADRVL I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	488.68867
Match:	1k8kE_
Description:	Arp2/3 complex 21 kDa subunit ARPC3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	5.63989846641024	bayes_pls_golite062009
cytoskeletal protein binding	4.21664682046338	bayes_pls_golite062009
actin filament binding	3.53574857524507	bayes_pls_golite062009
structural constituent of cytoskeleton	2.90019731783322	bayes_pls_golite062009
binding	1.94576284584165	bayes_pls_golite062009
protein binding	0.756249220099259	bayes_pls_golite062009
structural molecule activity	0.662672430262145	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [72-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGILFINDCL AHLKITTSFN EAVKVLTNVA LDNFTLPGTP GFPLNNVYQV PVQDHNSMDL  60
   61 LKTYIQQFRQ ELAMRLLERV YSSTDSKEYP SKFWLAFTRR RFMNKSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	488.68867
Match:	1k8kE_
Description:	Arp2/3 complex 21 kDa subunit ARPC3
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: