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Protein Overview: GUF1

General Information:
Name(s) found: GUF1 / YLR289W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 645 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: GTPase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKFRIRPVR HIRCYKRHAY FLRYNHTTTP AQKLQAQIEQ IPLENYRNFS IVAHVDHGKS  60
   61 TLSDRLLEIT HVIDPNARNK QVLDKLEVER ERGITIKAQT CSMFYKDKRT GKNYLLHLID 120
  121 TPGHVDFRGE VSRSYASCGG AILLVDASQG IQAQTVANFY LAFSLGLKLI PVINKIDLNF 180
  181 TDVKQVKDQI VNNFELPEED IIGVSAKTGL NVEELLLPAI IDRIPPPTGR PDKPFRALLV 240
  241 DSWYDAYLGA VLLVNIVDGS VRKNDKVICA QTKEKYEVKD IGIMYPDRTS TGTLKTGQVG 300
  301 YLVLGMKDSK EAKIGDTIMH LSKVNETEVL PGFEEQKPMV FVGAFPADGI EFKAMDDDMS 360
  361 RLVLNDRSVT LERETSNALG QGWRLGFLGS LHASVFRERL EKEYGSKLII TQPTVPYLVE 420
  421 FTDGKKKLIT NPDEFPDGAT KRVNVAAFHE PFIEAVMTLP QEYLGSVIRL CDSNRGEQID 480
  481 ITYLNTNGQV MLKYYLPLSH LVDDFFGKLK SVSRGFASLD YEDAGYRISD VVKLQLLVNG 540
  541 NAIDALSRVL HKSEVERVGR EWVKKFKEYV KSQLYEVVIQ ARANNKIIAR ETIKARRKDV 600
  601 LQKLHASDVS RRKKLLAKQK EGKKHMKTVG NIQINQEAYQ AFLRR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADH2 CDC53 DAP1 FAA1 GCN3 GUF1 HRT1 HRT3 IDH1 MKT1 PMA1 RIX7 RPN8 RTT101 SEC27 SKP1 SLC1 UBI4 VMA8 YHM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD1 GUF1 2 Unpublished Fields Lab Data
    View Screen CHL4 GUF1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GUF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304] PSI-BLAST 303.0 ELONGATION FACTOR G IN COMPLEX WITH GDP
    2 View Details [305..569] PSI-BLAST 303.0 ELONGATION FACTOR G IN COMPLEX WITH GDP
    3 View Details [570..645] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle