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Protein Overview: GZF3

General Information:
Name(s) found: GZF3 / YJL110C [SGD]
Description(s) found:
Found 30 descriptions.
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  • GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 551 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][ISSLink to PubMed article]
    nitrogen compound metabolic process [TASLink to PubMed article]
    negative regulation of transcription [IDALink to PubMed article]
    regulation of nitrogen utilization [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASQATTLRG YNIRKRDNVF EPKSSENLNS LNQSEEEGHI GRWPPLGYEA VSAEQKSAVQ  60
   61 LRESQAGASI SNNMNFKAND KSFSTSTAGR MSPDTNSLHH ILPKNQVKNN GQTMDANCNN 120
  121 NVSNDANVPV CKNCLTSTTP LWRRDEHGAM LCNACGLFLK LHGKPRPISL KTDVIKSRNR 180
  181 KSNTNHAHNL DNFRNQTLIA ELKGDCNIES SGRKANRVTS EDKKKKSSQL LMGTSSTAKI 240
  241 SKKPKTESKE RSDSHLSATK LEVLMSGDCS RPNLKPKLPK QDTAIYQEKL LTFPSYTDVK 300
  301 EYSNSAHQSA FIKERSQFNA ASFPLNASHS VTSKTGADSP QLPHLSMLLG SLSSTSISNN 360
  361 GSEIVSNCNN GIASTAATLA PTSSRTTDSN PSEVPNQIRS TMSSPDIISA KRNDPAPLSF 420
  421 HMASINDMLE TRDRAISNVK TETTPPHFIP FLQSSKAPCI SKANSQSISN SVSSSDVSGR 480
  481 KFENHPAKDL GDQLSTKLHK EEEIIKLKTR INELELVTDL YRRHINELDG KCRALEERLQ 540
  541 RTVKQEGNKG G

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YIF1 GZF3 2 Unpublished Fields Lab Data
    View Screen PDI1 GZF3 1 Unpublished Fields Lab Data
    View Screen SXM1 GZF3 1 Unpublished Fields Lab Data
    View Screen AGA2 GZF3 1 Unpublished Fields Lab Data
    View Screen SPP382 GZF3 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GZF3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] deduced N/A No confident structure predictions are available.
    2 View Details [124..192] PSI-BLAST 173.68867 Erythroid transcription factor GATA-1
    3 View Details [193..478] MSA 19.197997 View MSA. No confident structure predictions are available.
    4 View Details [479..551] MSA 1.003984 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.62841402245495 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62405765585032 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.68943696300126 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle