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View Structure Prediction Details

Protein: GZF3
Organism: Saccharomyces cerevisiae
Length: 551 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GZF3.

Description E-value Query
Range
Subject
Range
GZF3_YEAST - Protein GZF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GZF3 PE=1 SV=1
GZF3 - GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expres...
0.0 [1..551] [1..551]
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
3.0E-45 [6..419] [625..1037]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-39 [74..180] [1..108]
gi|8648977 - gi|8648977|emb|CAB94842.1| GATA-4 zinc-finger transcription factor [Oryctolagus cuniculus]
4.0E-39 [73..186] [2..116]
gi|3702858 - gi|3702858|gb|AAC62961.1| GATA transcription factor [Strongylocentrotus purpuratus]
1.0E-37 [76..191] [2..119]
gi|18032000 - gi|18032000|gb|AAL32068.1| pannier-like protein [Calliphora vicina]
6.0E-35 [3..341] [49..399]
gi|119112909, gi... - ref|XP_307949.1| ENSANGP00000006261 [Anopheles gambiae], gi|119112909|ref|XP_307949.3| AGAP002235-P...
gi|15420800 - gi|15420800|gb|AAK97462.1|AF395080_1 zinc finger transcription factor pannier [Anopheles gambiae]
2.0E-33 [2..330] [44..369]
gi|7381420 - gi|7381420|gb|AAF61481.1|AF184154_1 zinc finger DNA binding protein pannier [Ceratitis capitata]
3.0E-33 [3..189] [42..223]
gi|603164 - gi|603164|gb|AAA67886.1| BmGATA beta isoform 1
6.0E-33 [63..205] [59..200]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASQATTLRG YNIRKRDNVF EPKSSENLNS LNQSEEEGHI GRWPPLGYEA VSAEQKSAVQ  60
   61 LRESQAGASI SNNMNFKAND KSFSTSTAGR MSPDTNSLHH ILPKNQVKNN GQTMDANCNN 120
  121 NVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [124-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDANVPVCKN CLTSTTPLWR RDEHGAMLCN ACGLFLKLHG KPRPISLKTD VIKSRNRKSN  60
   61 TNHAHNLDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 173.68867
Match: 4gatA_
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
sequence-specific DNA binding 1.62841402245495 bayes_pls_golite062009
transcription activator activity 1.62405765585032 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [193-478]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRNQTLIAEL KGDCNIESSG RKANRVTSED KKKKSSQLLM GTSSTAKISK KPKTESKERS  60
   61 DSHLSATKLE VLMSGDCSRP NLKPKLPKQD TAIYQEKLLT FPSYTDVKEY SNSAHQSAFI 120
  121 KERSQFNAAS FPLNASHSVT SKTGADSPQL PHLSMLLGSL SSTSISNNGS EIVSNCNNGI 180
  181 ASTAATLAPT SSRTTDSNPS EVPNQIRSTM SSPDIISAKR NDPAPLSFHM ASINDMLETR 240
  241 DRAISNVKTE TTPPHFIPFL QSSKAPCISK ANSQSISNSV SSSDVS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [479-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRKFENHPAK DLGDQLSTKL HKEEEIIKLK TRINELELVT DLYRRHINEL DGKCRALEER  60
   61 LQRTVKQEGN KGG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.807 0.028 regulation of nitrogen utilization a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle