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Protein Overview: RRM3

General Information:
Name(s) found: RRM3 / YHR031C [SGD]
Description(s) found:
Found 22 descriptions.
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  • DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 723 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDALink to PubMed article][IMPLink to PubMed article]
    nuclear telomeric heterochromatin [IPILink to PubMed article]
    Biological Process: DNA replication [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    mitochondrial genome maintenance [IGILink to PubMed article]
    Molecular Function: DNA helicase activity [IMPLink to PubMed article][ISSLink to PubMed article]
    ATP-dependent DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRSHASGNK KQWSKRSSNG STPAASASGS HAYRQQTLSS FFMGCGKKSA AASKNSTTII  60
   61 DLESGDEGNR NITAPPRPRL IRNNSSSLFS QSQGSFGDDD PDAEFKKLVD VPRLNSYKKS 120
  121 SRSLSMTSSL HKTASASTTQ KTYHFDEDET LREVTSVKSN SRQLSFTSTI NIEDSSMKLS 180
  181 TDSERPAKRS KPSMEFQGLK LTVPKKIKPL LRKTVSNMDS MNHRSASSPV VLTMEQERVV 240
  241 NLIVKKRTNV FYTGSAGTGK SVILQTIIRQ LSSLYGKESI AITASTGLAA VTIGGSTLHK 300
  301 WSGIGIGNKT IDQLVKKIQS QKDLLAAWRY TKVLIIDEIS MVDGNLLDKL EQIARRIRKN 360
  361 DDPFGGIQLV LTGDFFQLPP VAKKDEHNVV KFCFESEMWK RCIQKTILLT KVFRQQDNKL 420
  421 IDILNAIRYG ELTVDIAKTI RNLNRDIDYA DGIAPTELYA TRREVELSNV KKLQSLPGDL 480
  481 YEFKAVDNAP ERYQAILDSS LMVEKVVALK EDAQVMMLKN KPDVELVNGS LGKVLFFVTE 540
  541 SLVVKMKEIY KIVDDEVVMD MRLVSRVIGN PLLKESKEFR QDLNARPLAR LERLKILINY 600
  601 AVKISPHKEK FPYVRWTVGK NKYIHELMVP ERFPIDIPRE NVGLERTQIP LMLCWALSIH 660
  661 KAQGQTIQRL KVDLRRIFEA GQVYVALSRA VTMDTLQVLN FDPGKIRTNE RVKDFYKRLE 720
  721 TLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) DNA2 HCS1 MCM2 MCM4 MCM6 MCM7 POL31 POL32 RAD18 RFC1 RFC4 RRM3 SUB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD9 RRM3 2 Unpublished Fields Lab Data
    View Screen PDI1 RRM3 1 Unpublished Fields Lab Data
    View Screen CDC13 RRM3 1 Unpublished Fields Lab Data
    View Screen SCL1 RRM3 1 Unpublished Fields Lab Data
    View Screen MDM30 RRM3 1 Unpublished Fields Lab Data
    View Screen UBC7 RRM3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RRM3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] MSA 2.129989 View MSA. No confident structure predictions are available.
    2 View Details [85..145] deduced N/A No confident structure predictions are available.
    3 View Details [146..226] PSI-BLAST 21.154902 Signal recognition particle receptor, FtsY; GTPase domain of the signal recognition particle receptor FtsY
    4 View Details [227..723] PSI-BLAST 63.045757 DEXX box DNA helicase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.94645534451735 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  3.91355858456767 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  3.38712979169347 bayes_pls_golite062009
  • DNA polymerase activity
    		•  3.34317110957534 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.81138802583782 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.66853770005159 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.28350783207533 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.1110976601505 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.11103644113672 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.1086792521709 bayes_pls_golite062009
  • nucleotide binding
    		•  1.1060655022247 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATP binding
    		•  0.80197288940364 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.770085840885632 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.751575230566049 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.60036517876321 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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