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View Structure Prediction Details

Protein: RRM3
Organism: Saccharomyces cerevisiae
Length: 723 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RRM3.

Description E-value Query
Range
Subject
Range
RRM3 - DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at...
RRM3_YEAST - ATP-dependent DNA helicase RRM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRM3 PE=...
0.0 [1..723] [1..723]
gi|15228453, gi|... - gi|7801660|emb|CAB91581.1| putative protein [Arabidopsis thaliana], gi|15228453|ref|NP_189796.1| AT ...
1.0E-84 [85..651] [1143..1751]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-81 [142..722] [219..784]
PIF1_SCHPO - ATP-dependent DNA helicase pfh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pfh1 PE=1 ...
pfh1 - pif1 helicase homolog Pfh1
4.0E-81 [142..722] [219..784]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRSHASGNK KQWSKRSSNG STPAASASGS HAYRQQTLSS FFMGCGKKSA AASKNSTTII  60
   61 DLESGDEGNR NITAPPRPRL IRNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSLFSQSQG SFGDDDPDAE FKKLVDVPRL NSYKKSSRSL SMTSSLHKTA SASTTQKTYH  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 3.94645534451735 bayes_pls_golite062009
protein-DNA loading ATPase activity 3.91355858456767 bayes_pls_golite062009
DNA-directed DNA polymerase activity 3.38712979169347 bayes_pls_golite062009
DNA polymerase activity 3.34317110957534 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
pyrophosphatase activity 1.81138802583782 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
deoxyribonuclease activity 1.66853770005159 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
telomeric DNA binding 1.28350783207533 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
purine ribonucleotide binding 1.1110976601505 bayes_pls_golite062009
ribonucleotide binding 1.11103644113672 bayes_pls_golite062009
purine nucleotide binding 1.1086792521709 bayes_pls_golite062009
nucleotide binding 1.1060655022247 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ATP binding 0.80197288940364 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
adenyl ribonucleotide binding 0.770085840885632 bayes_pls_golite062009
adenyl nucleotide binding 0.751575230566049 bayes_pls_golite062009
transcription factor activity 0.697256579145077 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
structural constituent of ribosome 0.208665086324262 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [146-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDETLREVT SVKSNSRQLS FTSTINIEDS SMKLSTDSER PAKRSKPSME FQGLKLTVPK  60
   61 KIKPLLRKTV SNMDSMNHRS A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.154902
Match: 1fts__
Description: Signal recognition particle receptor, FtsY; GTPase domain of the signal recognition particle receptor FtsY
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [227-723]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPVVLTMEQ ERVVNLIVKK RTNVFYTGSA GTGKSVILQT IIRQLSSLYG KESIAITAST  60
   61 GLAAVTIGGS TLHKWSGIGI GNKTIDQLVK KIQSQKDLLA AWRYTKVLII DEISMVDGNL 120
  121 LDKLEQIARR IRKNDDPFGG IQLVLTGDFF QLPPVAKKDE HNVVKFCFES EMWKRCIQKT 180
  181 ILLTKVFRQQ DNKLIDILNA IRYGELTVDI AKTIRNLNRD IDYADGIAPT ELYATRREVE 240
  241 LSNVKKLQSL PGDLYEFKAV DNAPERYQAI LDSSLMVEKV VALKEDAQVM MLKNKPDVEL 300
  301 VNGSLGKVLF FVTESLVVKM KEIYKIVDDE VVMDMRLVSR VIGNPLLKES KEFRQDLNAR 360
  361 PLARLERLKI LINYAVKISP HKEKFPYVRW TVGKNKYIHE LMVPERFPID IPRENVGLER 420
  421 TQIPLMLCWA LSIHKAQGQT IQRLKVDLRR IFEAGQVYVA LSRAVTMDTL QVLNFDPGKI 480
  481 RTNERVKDFY KRLETLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.045757
Match: 1pjr__
Description: DEXX box DNA helicase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle