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Protein Overview: GUT1

General Information:
Name(s) found: GUT1 / YHL032C [SGD]
Description(s) found:
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  • gi|6321755|ref|NP_011831.1| Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; Gut [NCBI NR]
  • pir||S33907 glycerol kinase (EC 2.7.1.30) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|417068|sp|P32190.1|GLPK_YEAST RecName: Full=Glycerol kinase; AltName: Full=ATP:glycerol 3-phosphotransferase; AltName: Full=Glycerokinase; Short=GK [NCBI NR]
  • gi|312423|emb|CAA48791.1| glycerol kinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2289861|gb|AAB65044.1| glycerol kinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1096962|prf||2113212A glycerol kinase [NCBI NR]
  • Glycerol kinase OS=Saccharomyces cerevisiae GN=GUT1 PE=1 SV=1 [Swiss-Prot]
  • GUT1 Glycerol kinase [mips]
  • Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p [SGD]
  • GUT1, Chr VIII from 36377-38506, reverse complement [yeast_orfs2]
  • Chr VIII from 36377-38506, reverse complement [yeastorf3.fasta]
  • Chr VIII from 38506-36377, reverse complement [yeastorf5.fasta]
  • (P32190) Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) [4932.FASTACCERV.txt]
  • GUT1 SGDID:S0001024, Chr VIII from 38506-36377, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p [Saccharomyces cerevisiae]gi|31 [nrdb_11152004_Chlamydomonas]
  • GUT1 SGDID:S000001024, Chr VIII from 38506-36377, reverse complement, Verified ORF, "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-ferme [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • glycerol kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • glycerol kinase [nr-271106-contam.fasta]
  • Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; Gut1p [Saccharomyces cerevisiae [nr-271106-contam.fasta]
  • Glycerol kinase (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) [nr-271106-contam.fasta]
  • GUT1 SGDID:S000001024, Chr VIII from 38506-36377, reverse complement, Verified ORF, "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Glycerol kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUT1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GUT1 SGDID:S000001024, Chr VIII from 38508-36379, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" [yeast-030211-contam.fasta]
  • Glycerol kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUT1 PE=3 SV=1 [YEAST.fasta.20131015]
  • GUT1 SGDID:S000001024, Chr VIII from 38508-36379, Genome Release 64-2-1, reverse complement, Verified ORF, "Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" [20141208_orf_trans.fasta]
  • YHL032C SGDID:S000001024, Chr VIII from 38508-36379, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 709 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: glycerol metabolic process [TASLink to PubMed article]
    Molecular Function: glycerol kinase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPSLFRLVV FSKRYIFRSS QRLYTSLKQE QSRMSKIMED LRSDYVPLIA SIDVGTTSSR  60
   61 CILFNRWGQD VSKHQIEYST SASKGKIGVS GLRRPSTAPA RETPNAGDIK TSGKPIFSAE 120
  121 GYAIQETKFL KIEELDLDFH NEPTLKFPKP GWVECHPQKL LVNVVQCLAS SLLSLQTINS 180
  181 ERVANGLPPY KVICMGIANM RETTILWSRR TGKPIVNYGI VWNDTRTIKI VRDKWQNTSV 240
  241 DRQLQLRQKT GLPLLSTYFS CSKLRWFLDN EPLCTKAYEE NDLMFGTVDT WLIYQLTKQK 300
  301 AFVSDVTNAS RTGFMNLSTL KYDNELLEFW GIDKNLIHMP EIVSSSQYYG DFGIPDWIME 360
  361 KLHDSPKTVL RDLVKRNLPI QGCLGDQSAS MVGQLAYKPG AAKCTYGTGC FLLYNTGTKK 420
  421 LISQHGALTT LAFWFPHLQE YGGQKPELSK PHFALEGSVA VAGAVVQWLR DNLRLIDKSE 480
  481 DVGPIASTVP DSGGVVFVPA FSGLFAPYWD PDARATIMGM SQFTTASHIA RAAVEGVCFQ 540
  541 ARAILKAMSS DAFGEGSKDR DFLEEISDVT YEKSPLSVLA VDGGMSRSNE VMQIQADILG 600
  601 PCVKVRRSPT AECTALGAAI AANMAFKDVN ERPLWKDLHD VKKWVFYNGM EKNEQISPEA 660
  661 HPNLKIFRSE SDDAERRKHW KYWEVAVERS KGWLKDIEGE HEQVLENFQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C
    View Details Gavin AC, et al. (2002) CCT4 CHC1 COG8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GUT1 IST1 PDC1 PRO1 RRP40 RRP46 SUI2 SUI3 XKS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GUT1 Huh WK, et al. (2003)
    View Data GUT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..384] PSI-BLAST 996.54902 Glycerol kinase
    3 View Details [385..457]
    [611..645]    		 PSI-BLAST 996.54902 Glycerol kinase
    4 View Details [458..610]
    [646..709]    		 PSI-BLAST 996.54902 Glycerol kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • glycerol kinase activity
    		•  5.25911418019759 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • glucose binding
    		•  1.58717365638543 bayes_pls_golite062009
  • binding
    		•  1.44744777288539 bayes_pls_golite062009
  • protein binding
    		•  0.704303457266874 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • sugar binding
    		•  0.44352406324938 bayes_pls_golite062009
  • kinase activity
    		•  0.345540463799773 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.324655711623803 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.214617425075414 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.20435276425198 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.132883501060045 bayes_pls_golite062009
  • hydrolase activity
    		•  0.13181840194556 bayes_pls_golite062009
  • transferase activity
    		•  0.105619024604158 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle