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Protein Overview: PAN2

General Information:
Name(s) found: PAN2 / YGL094C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1115 amino acids

    Gene Ontology:
    Cellular Component: PAN complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: mRNA 3'-end processing [IMPLink to PubMed article][IPILink to PubMed article]
    mRNA processing [IMPLink to PubMed article][IPILink to PubMed article]
    postreplication repair [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: poly(A)-specific ribonuclease activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNWQHFFNN PVDLSEHLKK PYFRFDNRDK EITAISFDEK ANLIWSGDSY GCISSYDPTF  60
   61 QLYTRYRGHI GGNSVKDILS HRDGILSISE DSLHFANRRG VTKLNLTSID IAAFSELNTM 120
  121 CYSPHSLKNN IYCGGDNTNW GIASIDLNRG CLDSLLNYSS KVKLMCSNNK VLSIGRQTGT 180
  181 VDLLDPTSNR TIKSFNAHSA SISAMDLRDN TLVTVGKSKR FYNLYADPFV NVYDLRTMRQ 240
  241 LPPVSFSKGT TMGSGGADFV QLHPLLPTVM IVASSSGSFD FIDLSNPTLR TQYVHPCQSI 300
  301 KKLCLSPNGD VLGILEADNH LDTWRRSSNN MGMFTNTPEM LAYPDYFNDI TSDGPISVDD 360
  361 ETYPLSSVGM PYYLDKLLSA WPPVVFKSEG TIPQLTGKSP LPSSGKLKSN LAVISSQNEK 420
  421 LSTQEFPLLR YDRTKYGMRN AIPDYVCLRD IRKQITSGLE TSDIQTYTSI NKYEVPPAYS 480
  481 RLPLTSGRFG TDNFDFTPFN NTEYSGLDPD VDNHYTNAII QLYRFIPEMF NFVVGCLKDE 540
  541 NFETTLLTDL GYLFDMMERS HGKICSSSNF QASLKSLTDK RQLENGEPQE HLEEYLESLC 600
  601 IRESIEDFNS SESIKRNMPQ KFNRFLLSQL IKEEAQTVNH NITLNQCFGL ETEIRTECSC 660
  661 DHYDTTVKLL PSLSISGINK TVIKQLNKKS NGQNILPYIE YAMKNVTQKN SICPTCGKTE 720
  721 TITQECTVKN LPSVLSLELS LLDTEFSNIR SSKNWLTSEF YGSIIKNKAV LRSTASELKG 780
  781 TSHIFKYELN GYVAKITDNN NETRLVTYVK KYNPKENCFK WLMFNDYLVV EITEEEALKM 840
  841 TYPWKTPEII IYCDAEELRK PFFSVDTYSI NYDILFRDYF ANGIRDTARR EYKLLTHDEA 900
  901 PKSGTLVAID AEFVSLQSEL CEIDHQGIRS IIRPKRTALA RISIIRGEEG ELYGVPFVDD 960
  961 YVVNTNHIED YLTRYSGILP GDLDPEKSTK RLVRRNVVYR KVWLLMQLGC VFVGHGLNND1020
 1021 FKHININVPR NQIRDTAIYF LQGKRYLSLR YLAYVLLGMN IQEGNHDSIE DAHTALILYK1080
 1081 KYLHLKEKAI FEKVLNSVYE EGRAHNFKVP ETSKG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PAN2 PAN3
    View Details Krogan NJ, et al. (2006) PAN2 PAN3
    View Details Gavin AC, et al. (2006) PAB1 PAN2 PAN3
    View Details Gavin AC, et al. (2002) PAN2 PAN3
    View Details Qiu et al. (2008) PAN2 PAN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PAN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..395] PSI-BLAST 75.522879 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [396..468] deduced N/A No confident structure predictions are available.
    3 View Details [469..895] MSA 58.218995 View MSA. No confident structure predictions are available.
    4 View Details [896..1115] ORFEUS 7.52 Exonuclease I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • ribonuclease activity
    		•  5.30591758406946 bayes_pls_golite062009
  • poly(A)-specific ribonuclease activity
    		•  4.26301879074656 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.71639182685131 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.59362615133405 bayes_pls_golite062009
  • exonuclease activity
    		•  3.13676176369406 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
    		• 3.10149405290966 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.91966688044755 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.57498413015114 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.12039058720352 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.80414039971082 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73824903971928 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.64519652804477 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.54576601235316 bayes_pls_golite062009
  • DNA binding
    		•  1.53383838980295 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • RNA binding
    		•  1.43996903907704 bayes_pls_golite062009
  • binding
    		•  1.35497934205068 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.897788693142573 bayes_pls_golite062009
  • transcription factor activity
    		•  0.893245368597729 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.541658282566651 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.206750180223289 bayes_pls_golite062009
  • protein binding
    		•  0.035326007863533 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle