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Protein Overview: TRP5

General Information:
Name(s) found: TRP5 / YGL026C [SGD]
Description(s) found:
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  • pir||TSBYAB tryptophan synthase (EC 4.2.1.20) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6321412|ref|NP_011489.1| Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis; Trp5p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4674|emb|CAA24635.1| trp5 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|136373|sp|P00931.1|TRP_YEAST RecName: Full=Tryptophan synthase [NCBI NR]
  • gi|1322496|emb|CAA96727.1| TRP5 [Saccharomyces cerevisiae] [NCBI NR]
  • Tryptophan synthase OS=Saccharomyces cerevisiae GN=TRP5 PE=1 SV=1 [Swiss-Prot]
  • TRP5 Tryptophan synthase [mips]
  • Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis [SGD]
  • TRP5, Chr VII from 446408-448531, reverse complement [yeast_orfs2]
  • Chr VII from 446408-448531, reverse complement [yeastorf3.fasta]
  • Chr VII from 446415-448538, reverse complement [yeastorf4.fasta]
  • Chr VII from 448538-446415, reverse complement [yeastorf5.fasta]
  • (P00931) Tryptophan synthase (EC 4.2.1.20) [4932.FASTACCERV.txt]
  • TRP5 SGDID:S0002994, Chr VII from 448538-446415, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TRP5 SGDID:S0002994, Chr VII from 448540-446417, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Trp5p [Saccharomyces cerevisiae]gi|1322496|emb|CAA96727.1| TRP5 [Saccharomyces cerevisiae]gi|68333|pir||TSBYAB tryptophan synthase (EC 4.2.1.20) - yeast (Saccharomyces cerevisiae)gi|136373|sp|P00931|TRP_YEAST Tryptophan synthasegi|4674|emb|CAA24635.1| [nrdb_11152004_Chlamydomonas]
  • TRP5 SGDID:S000002994, Chr VII from 448540-446417, reverse complement, Verified ORF, "Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • trp5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Tryptophan synthase [nr-271106-contam.fasta]
  • Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis; Trp5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TRP5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TRP5 SGDID:S000002994, Chr VII from 448540-446417, reverse complement, Verified ORF, "Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Tryptophan synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TRP5 SGDID:S000002994, Chr VII from 448535-446412, Genome Release 64-1-1, reverse complement, Verified ORF, "Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" [yeast-030211-contam.fasta]
  • TRP5 SGDID:S000002994, Chr VII from 448535-446412, Genome Release 64-2-1, reverse complement, Verified ORF, "Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" [20141208_orf_trans.fasta]
  • YGL026C SGDID:S000002994, Chr VII from 448535-446412, Genome Release 64-1-1, reverse complement, Verified ORF, "Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 707 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: tryptophan biosynthetic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: tryptophan synthase activity [IDALink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEQLRQTFA NAKKENRNAL VTFMTAGYPT VKDTVPILKG FQDGGVDIIE LGMPFSDPIA  60
   61 DGPTIQLSNT VALQNGVTLP QTLEMVSQAR NEGVTVPIIL MGYYNPILNY GEERFIQDAA 120
  121 KAGANGFIIV DLPPEEALKV RNYINDNGLS LIPLVAPSTT DERLELLSHI ADSFVYVVSR 180
  181 MGTTGVQSSV ASDLDELISR VRKYTKDTPL AVGFGVSTRE HFQSVGSVAD GVVIGSKIVT 240
  241 LCGDAPEGKR YDVAKEYVQG ILNGAKHKVL SKDEFFAFQK ESLKSANVKK EILDEFDENH 300
  301 KHPIRFGDFG GQYVPEALHA CLRELEKGFD EAVADPTFWE DFKSLYSYIG RPSSLHKAER 360
  361 LTEHCQGAQI WLKREDLNHT GSHKINNALA QVLLAKRLGK KNVIAETGAG QHGVATATAC 420
  421 AKFGLTCTVF MGAEDVRRQA LNVFRMRILG AKVIAVTNGT KTLRDATSEA FRFWVTNLKT 480
  481 TYYVVGSAIG PHPYPTLVRT FQSVIGKETK EQFAAMNNGK LPDAVVACVG GGSNSTGMFS 540
  541 PFEHDTSVKL LGVEAGGDGV DTKFHSATLT AGRPGVFHGV KTYVLQDSDG QVHDTHSVSA 600
  601 GLDYPGVGPE LAYWKSTGRA QFIAATDAQA LLGFKLLSQL EGIIPALESS HAVYGACELA 660
  661 KTMKPDQHLV INISGRGDKD VQSVAEVLPK LGPKIGWDLR FEEDPSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ACC1 AHA1 ARG1 ARO4 BGL2 CBP6 CDC33 CDC60 COR1 FPR1 FRS2 GCD11 GCN3 HXT7 ILS1 KGD2 KRS1 LPD1 MCX1 NDE1 NPA3 PET10 PET9 PMI40 RPA135 RPA190 RPC40 RVB2 RVS161 RVS167 SAC6 SES1 SLC1 SMC4 TRP3 TRP5 URE2 VMA4 VPS8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRP5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..280] PSI-BLAST 467.450636 Trp synthase alpha-subunit
    2 View Details [281..350]
    [384..501]    		 PSI-BLAST 1276.0 Tryptophan synthase, beta-subunit
    3 View Details [351..383]
    [502..707]    		 PSI-BLAST 1276.0 Tryptophan synthase, beta-subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • tryptophan synthase activity
    		•  3.62092042588636 bayes_pls_golite062009
  • catalytic activity
    		•  2.38994231321972 bayes_pls_golite062009
  • lyase activity
    		•  1.87743897464083 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  1.42195744285403 bayes_pls_golite062009
  • binding
    		•  1.34539784687114 bayes_pls_golite062009
  • cysteine synthase activity
    		•  1.31641967296632 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.923824749425553 bayes_pls_golite062009
  • threonine synthase activity
    		•  0.727838845253199 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.476674617721478 bayes_pls_golite062009
  • L-threonine ammonia-lyase activity
    		•  0.37325071016009 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  0.249761226675912 bayes_pls_golite062009
  • protein binding
    		•  0.044015703839169 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle