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Protein Overview: PRR2

General Information:
Name(s) found: PRR2 / YDL214C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 699 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Biological Process: MAPKKK cascade [IMPLink to PubMed article]
    Molecular Function: receptor signaling protein serine/threonine kinase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSRILRYN QRNNKTTASL TAEHAYSDNW AYSVSLGDPT SVGVNMAAKT GEALNKSYDS  60
   61 VFSSLPVADS VPRTDFTASS RDDENTDVQK LTTSWMEKID TKMPENISKI DSNIISSPMV 120
  121 SKVEARFIVP KGRLRKNSTD FTSSFSNSLS LPKSYGKLIF FTSKKNSSST KKNLANDISD 180
  181 NKHNNNSSNT IGHNIPVTTA TATCDEIACT STEHEYNVYE EERMFTTRVY SLEDSVSSLS 240
  241 TNPLDDTYSE AVQVNTRHIE DTESTAHIRK HSYTTSLSSI KRLFKITSFS NNNSNSCDHQ 300
  301 ESTVADDCAI SSSLKETTSS PVSTGSFSLM IENEDSDRDQ IIQALYSNIE ASTDLVSRKY 360
  361 RDLDVVLGEG SGGKVKLVQR VLDNKVFALK EYRSKKKRES ERKYIKNIIS EYCIASTLKN 420
  421 PNICETLEIL YEKGKIFQIL EYCEYDLFSL VMSEKMHYEE ICCLFKQLIN GVKYLHDIGL 480
  481 SHRDLKLDNC VVTRRGILKL IDFGASSVFH YPLSSQMIEA NGIVGSDPYL SPEVFYFNEY 540
  541 DPRALDVWSV GIIFFCMITR RFPWKYPKVK DVQFKAFCSG RGVSSFKDLV TRPATDDSNN 600
  601 YDNDGYEEGV IDMGPNFILH RLPEETHKIM RRILEVSPFR RITINGILQD GWIKEIETCQ 660
  661 VVGAASPNEA SLRIINKGNH IHTNIDQRYA HIGGLHQRT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNF4 PRR2 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] deduced N/A No confident structure predictions are available.
    2 View Details [321..442] PSI-BLAST 319.228787 Cyclin-dependent PK, CDK2
    3 View Details [443..524]
    [655..699]    		 PSI-BLAST 319.228787 Cyclin-dependent PK, CDK2
    4 View Details [525..575] PSI-BLAST 319.228787 Cyclin-dependent PK, CDK2
    5 View Details [576..654] PSI-BLAST 319.228787 Cyclin-dependent PK, CDK2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  4.75681284089441 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.41610417530517 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.36057410204148 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.25301480460598 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.188721764136 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.12618184009486 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • signal transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.65350201428136 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.63027742934354 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.28428643482914 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.27941426224024 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.22172815474021 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • receptor activity
    		•  1.13726344123824 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.913502744297219 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • telethonin binding
    		•  0.646132039779792 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • tubulin binding
    		•  0.525721160726465 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • protein complex binding
    		•  0.47697270662802 bayes_pls_golite062009
  • actin binding
    		•  0.456340967230669 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • cation channel activity
    		•  0.352588970491461 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • microtubule binding
    		•  0.191960933574742 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle