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View Structure Prediction Details

Protein: PRR2
Organism: Saccharomyces cerevisiae
Length: 699 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRR2.

Description E-value Query
Range		 Subject
Range
PRR2_YEAST - Serine/threonine-protein kinase PRR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRR...
PRR2 - Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possi...
 0.0 [1..699] [1..699]
gi|238478996, gi... - pir||D96699 hypothetical protein F12B7.13 [imported] - Arabidopsis thaliana, gi|238478996|ref|NP_00...
 0.0 [26..681] [55..725]
gi|4096103 - gi|4096103|gb|AAD10483.1| p34cdc2 [Triticum aestivum]
 0.0 [357..658] [1..292]
CDC2_MAIZE - Cell division control protein 2 homolog OS=Zea mays GN=CDC2 PE=2 SV=1
 0.0 [357..656] [1..290]
CDC21_ORYSA, CC2... - Cell division control protein 2 homolog 1 (EC 2.7.11.22) - Oryza sativa (Rice), (P29618) Cell divisi...
CDKA1_ORYSJ - Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica GN=CDKA-1 PE=1 SV=1
 0.0 [357..658] [1..292]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [357..658] [1..292]
CDK2_CARAU - Cyclin-dependent kinase 2 OS=Carassius auratus GN=cdk2 PE=2 SV=1
 0.0 [357..662] [1..295]
HGNC:1771|MIM:11... - kinase 2, kinase 2, kinase 2
gi|114644318 - gi|114644318|ref|XP_522432.2| PREDICTED: cyclin-dependent kinase 2 [Pan troglodytes]
CCDS8898.1_1 - null
gi|124126885, gi... - gi|61363082|gb|AAX42331.1| cyclin-dependent kinase 2 [synthetic construct], gi|60817417|gb|AAX36422....
CDK2 - cyclin-dependent kinase 2
 0.0 [357..659] [1..292]

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Predicted Domain #1
Region A:
Residues: [1-320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSRILRYN QRNNKTTASL TAEHAYSDNW AYSVSLGDPT SVGVNMAAKT GEALNKSYDS  60
   61 VFSSLPVADS VPRTDFTASS RDDENTDVQK LTTSWMEKID TKMPENISKI DSNIISSPMV 120
  121 SKVEARFIVP KGRLRKNSTD FTSSFSNSLS LPKSYGKLIF FTSKKNSSST KKNLANDISD 180
  181 NKHNNNSSNT IGHNIPVTTA TATCDEIACT STEHEYNVYE EERMFTTRVY SLEDSVSSLS 240
  241 TNPLDDTYSE AVQVNTRHIE DTESTAHIRK HSYTTSLSSI KRLFKITSFS NNNSNSCDHQ 300
  301 ESTVADDCAI SSSLKETTSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [321-442] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVSTGSFSLM IENEDSDRDQ IIQALYSNIE ASTDLVSRKY RDLDVVLGEG SGGKVKLVQR  60
   61 VLDNKVFALK EYRSKKKRES ERKYIKNIIS EYCIASTLKN PNICETLEIL YEKGKIFQIL 120
  121 EY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.228787
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [443-524] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEYDLFSLVM SEKMHYEEIC CLFKQLINGV KYLHDIGLSH RDLKLDNCVV TRRGILKLID  60
   61 FGASSVFHYP LSSQMIEANG IV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [655-699] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIETCQVVGA ASPNEASLRI INKGNHIHTN IDQRYAHIGG LHQRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.228787
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
acetylcholine receptor activator activity 4.75681284089441 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.41610417530517 bayes_pls_golite062009
protein tyrosine kinase activity 2.36057410204148 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
ion transmembrane transporter activity 2.25301480460598 bayes_pls_golite062009
cation transmembrane transporter activity 2.188721764136 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.12618184009486 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
molecular transducer activity 1.95775692939268 bayes_pls_golite062009
signal transducer activity 1.95775692939268 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.65350201428136 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
receptor signaling protein activity 1.63027742934354 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.28428643482914 bayes_pls_golite062009
transmembrane receptor activity 1.27941426224024 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.27740808551012 bayes_pls_golite062009
insulin receptor activity 1.22442673174261 bayes_pls_golite062009
cytoskeletal protein binding 1.22172815474021 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
receptor activity 1.13726344123824 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.96468055729151 bayes_pls_golite062009
ErbB-2 class receptor binding 0.913502744297219 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
telethonin binding 0.646132039779792 bayes_pls_golite062009
insulin binding 0.614254468447749 bayes_pls_golite062009
tubulin binding 0.525721160726465 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
protein complex binding 0.47697270662802 bayes_pls_golite062009
actin binding 0.456340967230669 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
cation channel activity 0.352588970491461 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
microtubule binding 0.191960933574742 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [525-575] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDPYLSPEV FYFNEYDPRA LDVWSVGIIF FCMITRRFPW KYPKVKDVQF K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.228787
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [576-654] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFCSGRGVSS FKDLVTRPAT DDSNNYDNDG YEEGVIDMGP NFILHRLPEE THKIMRRILE  60
   61 VSPFRRITIN GILQDGWIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.228787
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle