Protein Overview: CSH1

General Information:
Name(s) found:	CSH1 / YBR161W [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	376 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole [IDA]
Biological Process:	glycosphingolipid biosynthetic process [IMP][ISS] sphingolipid biosynthetic process [IMP]
Molecular Function:	transferase activity, transferring glycosyl groups [ISS] mannosyltransferase activity [IGI][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKELKILII ANIALLISII HYTFDLLTLC IDDTSKDALT DEQLNPPNGF NSTFYESPPQ  60
   61 LIPKIIHQTY KTNDIPEQWV KGRQKCIDLH PDYTYILWTD EMSDTFIKQE YPWFLDTFRS 120
  121 YEYPIERADA IRYFILSHYG GIYIDLDDGC ERRLDPLLKV PAFLRKTSPT GVSNDVMGSV 180
  181 PRHPFFLKVI KSLKHYKKNW YIPYMTIMGS TGPLFISVVW KQYKRWSNTA ENGAVRILQP 240
  241 ADYKMHNNSF FSISKGSSWH TGDANFMKTL ENHILSCVVT GFIFGFFILY GEFTFYTWLC 300
  301 SGPFNNKRYY IQWLSDKFKL HKWKLTSSYK NKEKRRNPTR HEYNSRGKRL RKDSNIPYDS 360
  361 VFLDIEKNHA KFTDLT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC53	CSH1	1	Unpublished Fields Lab Data
View Screen	LSM8	CSH1	1	Unpublished Fields Lab Data
View Screen	ELM1	CSH1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CSH1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..376]	MSA	9.043973	View MSA. No confident structure predictions are available.
2	View Details	[276..376]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	3.53745786560416	bayes_pls_golite062009
transferase activity	2.31990837710257	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.11502695067396	bayes_pls_golite062009
catalytic activity	1.73979371332125	bayes_pls_golite062009
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	1.44394626846909	bayes_pls_golite062009
galactosyltransferase activity	0.853604327554002	bayes_pls_golite062009
nucleotidyltransferase activity	0.641710647713692	bayes_pls_golite062009
cytidylyltransferase activity	0.507775977022676	bayes_pls_golite062009
UDP-galactosyltransferase activity	0.399297528195959	bayes_pls_golite062009
binding	0.360289245468159	bayes_pls_golite062009
UDP-glycosyltransferase activity	0.126802120207723	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2