YRC Public Data Repository - Protein Structure Prediction

Protein:	CSH1
Organism:	Saccharomyces cerevisiae
Length:	376 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSH1.

Description	E-value	Query Range	Subject Range
CSH1 - Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex... gi\|151946550 - gi\|151946550\|gb\|EDN64772.1\| CSG1/SUR1-like protein [Saccharomyces cerevisiae YJM789] gi\|207347608 - gi\|207347608\|gb\|EDZ73722.1\| YBR161Wp-like protein [Saccharomyces cerevisiae AWRI1631] CSH1_YEAST - Mannosyl phosphorylinositol ceramide synthase CSH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /... gi\|190408686 - gi\|190408686\|gb\|EDV11951.1\| mannosyl phosphorylinositol ceramide synthase SUR1 [Saccharomyces cerevi...	0.0	[1..376]	[1..376]
IMT2_SCHPO - Inositol phosphoceramide mannosyltransferase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843... SPCC4F11.04c - mannosyltransferase complex subunit	2.0E-74	[7..294]	[10..316]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-56	[33..273]	[9..254]
gi\|22534196, gi\|... - gi\|22537325\|ref\|NP_688176.1\| polysaccharide biosynthesis protein CpsM(V) [Streptococcus agalactiae 2... gi\|90577001, gi\|... - gi\|90577091\|gb\|ABD95675.1\| CpsM [Streptococcus agalactiae], gi\|90577072\|gb\|ABD95657.1\| CpsM [Strepto...	7.0E-48	[61..295]	[1..236]
gi\|17978673 - gi\|17978673\|gb\|AAL49987.1\| putative mannosyltransferase [Candida albicans]	4.0E-45	[26..262]	[64..378]
gi\|254847069, gi... - gi\|75831229\|ref\|ZP_00760495.1\| COG3774: Mannosyltransferase OCH1 and related enzymes [Vibrio cholera... gi\|75828223, gi\|... - gi\|75828223\|ref\|ZP_00757658.1\| COG3774: Mannosyltransferase OCH1 and related enzymes [Vibrio cholera... gi\|229369129, gi... - gi\|229606474\|ref\|YP_002877122.1\| mannosyltransferase OCH1-like enzyme [Vibrio cholerae MJ-1236], gi\|... gi\|229516283, gi... - gi\|229516283\|ref\|ZP_04405731.1\| mannosyltransferase OCH1 and related enzymes [Vibrio cholerae RC9], ... gi\|229356071, gi... - gi\|229506966\|ref\|ZP_04396474.1\| mannosyltransferase OCH1 and related enzymes [Vibrio cholerae BX 330... gi\|9654642, gi\|1... - gi\|9654642\|gb\|AAF93410.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|227080454, gi... - gi\|227080454\|ref\|YP_002809005.1\| hypothetical protein VCM66_0222 [Vibrio cholerae M66-2], gi\|2270083... gi\|11354503 - pir\|\|D82349 conserved hypothetical protein VC0234 [imported] - Vibrio cholerae (strain N16961 serogr... gi\|121586362, gi... - gi\|121586362\|ref\|ZP_01676151.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215494... gi\|153221445, gi... - gi\|153221445\|ref\|ZP_01952403.1\| conserved hypothetical protein [Vibrio cholerae MAK 757], gi\|1241196... gi\|126511179, gi... - gi\|153818290\|ref\|ZP_01970957.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|229509336, gi... - gi\|229509336\|ref\|ZP_04398819.1\| mannosyltransferase OCH1 and related enzymes [Vibrio cholerae B33], ...	5.0E-45	[11..222]	[6..218]
gi\|18653302 - gi\|18653302\|gb\|AAL77372.1\|AF449195_7 putative glycosyl transferase [Vibrio cholerae]	7.0E-44	[15..221]	[8..216]
gi\|15602981, gi\|... - gi\|15602981\|ref\|NP_246053.1\| hypothetical protein PM1116 [Pasteurella multocida subsp. multocida str...	3.0E-43	[19..237]	[10..232]

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Predicted Domain #1

Region A:
Residues: [1-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKELKILII ANIALLISII HYTFDLLTLC IDDTSKDALT DEQLNPPNGF NSTFYESPPQ  60
   61 LIPKIIHQTY KTNDIPEQWV KGRQKCIDLH PDYTYILWTD EMSDTFIKQE YPWFLDTFRS 120
  121 YEYPIERADA IRYFILSHYG GIYIDLDDGC ERRLDPLLKV PAFLRKTSPT GVSNDVMGSV 180
  181 PRHPFFLKVI KSLKHYKKNW YIPYMTIMGS TGPLFISVVW KQYKRWSNTA ENGAVRILQP 240
  241 ADYKMHNNSF FSISKGSSWH TGDANFMKTL ENHILSCVVT GFIFGFFILY GEFTFYTWLC 300
  301 SGPFNNKRYY IQWLSDKFKL HKWKLTSSYK NKEKRRNPTR HEYNSRGKRL RKDSNIPYDS 360
  361 VFLDIEKNHA KFTDLT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	3.53745786560416	bayes_pls_golite062009
transferase activity	2.31990837710257	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.11502695067396	bayes_pls_golite062009
catalytic activity	1.73979371332125	bayes_pls_golite062009
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	1.44394626846909	bayes_pls_golite062009
galactosyltransferase activity	0.853604327554002	bayes_pls_golite062009
nucleotidyltransferase activity	0.641710647713692	bayes_pls_golite062009
cytidylyltransferase activity	0.507775977022676	bayes_pls_golite062009
UDP-galactosyltransferase activity	0.399297528195959	bayes_pls_golite062009
binding	0.360289245468159	bayes_pls_golite062009
UDP-glycosyltransferase activity	0.126802120207723	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [276-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCVVTGFIFG FFILYGEFTF YTWLCSGPFN NKRYYIQWLS DKFKLHKWKL TSSYKNKEKR  60
   61 RNPTRHEYNS RGKRLRKDSN IPYDSVFLDI EKNHAKFTDL T

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: