Protein Overview: CDC24

General Information:
Name(s) found:	CDC24 / YAL041W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319276\|ref\|NP_009359.1\| Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; Cdc24p [Saccharomyces cerevis [NCBI NR] gi\|1345705\|sp\|P11433.2\|CDC24_YEAST RecName: Full=Cell division control protein 24; AltName: Full=Calcium regulatory protein [NCBI NR] gi\|1101003\|gb\|AAC04990.1\| Cdc24p: putative calcium binding protein [Saccharomyces cerevisiae] [NCBI NR] gi\|1100997\|gb\|AAA82871.1\| calcium regulatory protein [NCBI NR] Cell division control protein 24 OS=Saccharomyces cerevisiae GN=CDC24 PE=1 SV=2 [Swiss-Prot] (P11433) Cell division control protein 24 (Calcium regulatory protein) [Swiss-Prot] CDC24 GTP/GDP exchange factor for Cdc42p [mips] Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing [SGD] CDC24, Chr I from 62842-65406 [yeast_orfs2] Chr I from 62842-65406 [yeastorf3.fasta] CDC24 SGDID:S0000039, Chr I from 62843-65407, Verified ORF [yeastflysequest.fasta] CDC24 SGDID:S0000039, Chr I from 62841-65405, Verified ORF [10112005cervSGD.fasta] Cdc24p [Saccharomyces cerevisiae]gi\|1101003\|gb\|AAC04990.1\| Cdc24p: putative calcium binding protein [Saccharomyces cerevisiae]gi\|1100997\|gb\|AAA82871.1\| calcium regulatory proteingi\|1345705\|sp\|P11433\|CC24_YEAST Cell division control protein 24 (Calcium [nrdb_11152004_Chlamydomonas] CDC24 SGDID:S000000039, Chr I from 62841-65405, Verified ORF, "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; Cdc24p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Cdc24p: putative calcium binding protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] calcium regulatory protein [nr-271106-contam.fasta] Cell division control protein 24 (Calcium regulatory protein) [nr-271106-contam.fasta] CDC24 SGDID:S000000039, Chr I from 62841-65405, Verified ORF, "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Cell division control protein 24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC24 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC24 SGDID:S000000039, Chr I from 62840-65404, Genome Release 64-1-1, Verified ORF, "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing" [yeast-030211-contam.fasta] CDC24 SGDID:S000000039, Chr I from 62840-65404, Genome Release 64-2-1, Verified ORF, "Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta] YAL041W SGDID:S000000039, Chr I from 62840-65404, Genome Release 64-1-1, Verified ORF, "Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	854 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] incipient cellular bud site [IDA] cellular bud neck [IDA] mating projection tip [IDA]
Biological Process:	budding cell isotropic bud growth [IPI] small GTPase mediated signal transduction [TAS] regulation of exit from mitosis [IMP] pseudohyphal growth [IPI] chitin localization [IMP] invasive growth in response to glucose limitation [IPI] cell morphogenesis involved in conjugation with cellular fusion [IMP][IPI] budding cell apical bud growth [IPI] pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI][IPI][TAS]
Molecular Function:	Rho guanyl-nucleotide exchange factor activity [IDA] signal transducer activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI RKRLEVLPQL  60
   61 KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS SDLAPTLRSS SISTATSLMS 120
  121 MEGISYTNSN PSATPNMEDT LLTFSMGILP ITMDCDPVTQ LSQLFQQGAP LCILFNSVKP 180
  181 QFKLPVIASD DLKVCKKSIY DFILGCKKHF AFNDEELFTI SDVFANSTSQ LVKVLEVVET 240
  241 LMNSSPTIFP SKSKTQQIMN AENQHRHQPQ QSSKKHNEYV KIIKEFVATE RKYVHDLEIL 300
  301 DKYRQQLLDS NLITSEELYM LFPNLGDAID FQRRFLISLE INALVEPSKQ RIGALFMHSK 360
  361 HFFKLYEPWS IGQNAAIEFL SSTLHKMRVD ESQRFIINNK LELQSFLYKP VQRLCRYPLL 420
  421 VKELLAESSD DNNTKELEAA LDISKNIARS INENQRRTEN HQVVKKLYGR VVNWKGYRIS 480
  481 KFGELLYFDK VFISTTNSSS EPEREFEVYL FEKIIILFSE VVTKKSASSL ILKKKSSTSA 540
  541 SISASNITDN NGSPHHSYHK RHSNSSSSNN IHLSSSSAAA IIHSSTNSSD NNSNNSSSSS 600
  601 LFKLSANEPK LDLRGRIMIM NLNQIIPQNN RSLNITWESI KEQGNFLLKF KNEETRDNWS 660
  661 SCLQQLIHDL KNEQFKARHH SSTSTTSSTA KSSSMMSPTT TMNTPNHHNS RQTHDSMASF 720
  721 SSSHMKRVSD VLPKRRTTSS SFESEIKSIS ENFKNSIPES SILFRISYNN NSNNTSSSEI 780
  781 FTLLVEKVWN FDDLIMAINS KISNTHNNNI SPITKIKYQD EDGDFVVLGS DEDWNVAKEM 840
  841 LAENNEKFLN IRLY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BOI2 CDC24
View Details	Gavin AC, et al. (2006)		BOI2 CDC24
View Details	Gavin AC, et al. (2002)		BEM1 BOI2 CDC24 HSP42 RSC2 SIS1
View Details	Qiu et al. (2008)		BEM1 BNI1 BUD5 CDC24 CDC42 FAR1 FUS3 GIC1 GIC2 LRG1 MOB2 RHO1 ROM2 RSR1 SHO1 SKT5 STE4 STE5 TPM2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC24	SWE1	2	Drees BL, et al. (2001)
View Screen	CDC24	ENT2	2	Drees BL, et al. (2001)
View Screen	BEM1	CDC24	2	Drees BL, et al. (2001)
View Screen	CDC42	CDC24	2	Drees BL, et al. (2001)
View Screen	CDC24	BEM1	2	Drees BL, et al. (2001)
View Screen	CDC24	TOS2	2	Drees BL, et al. (2001)
View Screen	CDC24	AIR1	2	Drees BL, et al. (2001)
View Screen	CDC24	CCT8	2	Unpublished Fields Lab Data
View Screen	CDC24	FAR1	2	Drees BL, et al. (2001)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC24	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..133]	MSA	1.108997	View MSA. No confident structure predictions are available.
2	View Details	[134..253]	PSI-BLAST	11.69897	Calponin
3	View Details	[254..458]	PSI-BLAST	202.457575	GEF of TIAM1 (T-Lymphoma invasion and metastasis indusing protein 1)
4	View Details	[459..642]	PSI-BLAST	202.457575	GEF of TIAM1 (T-Lymphoma invasion and metastasis indusing protein 1)
5	View Details	[643..754]	MSA	1.061996	View MSA. No confident structure predictions are available.
6	View Details	[755..854]	deduced	N/A	Confident ab initio structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.24212855645397	bayes_pls_golite062009
protein binding	1.04550817342273	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.993282922991536	bayes_pls_golite062009
kinase activity	0.682664093464385	bayes_pls_golite062009
signal transducer activity	0.639296022362811	bayes_pls_golite062009
molecular transducer activity	0.639296022362811	bayes_pls_golite062009
GTPase regulator activity	0.459633124432679	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.457933659119243	bayes_pls_golite062009
small GTPase regulator activity	0.390993828682912	bayes_pls_golite062009
enzyme regulator activity	0.217422685675578	bayes_pls_golite062009
protein serine/threonine kinase activity	0.0693380673720717	bayes_pls_golite062009
protein kinase activity	0.0278354564906339	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2