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Protein Overview: PAS1_ARATH

General Information:
Name(s) found: PAS1_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|73921623|sp|Q7DMA9.2|PAS1_ARATH RecName: Full=Peptidyl-prolyl isomerase PASTICCINO1; AltName: Full=Peptidyl-prolyl cis-trans isomerase; Short=PPIase; Short=Rotamase [NCBI NR]
  • gi|20465605|gb|AAM20285.1| putative pasticcino 1 protein [Arabidopsis thaliana] [NCBI NR]
  • gi|18409970|ref|NP_566993.1| PAS1 (PASTICCINO 1); FK506 binding / binding / peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [NCBI NR]
  • gi|15810453|gb|AAL07114.1| putative pasticcino 1 protein [Arabidopsis thaliana] [NCBI NR]
  • Peptidyl-prolyl cis-trans isomerase PASTICCINO1 OS=Arabidopsis thaliana GN=PAS1 PE=1 SV=2 [Swiss-Prot]
  • putative pasticcino 1 protein [Arabidopsis thaliana]gi|15810453|gb|AAL07114.1| putative pasticcino 1 protein [Arabidopsis thaliana]gi|18409970|ref|NP_566993.1| peptidyl-prolyl cis-trans isomerase, putative / FK506-binding protein, putative / pasticcino [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Splice Isoform 1 of Peptidylprolyl isomerase PASTICCINO1 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: DEI1, PAS1 | PAS1 (PASTICCINO 1); FK506 binding / peptidyl-prolyl cis-trans isomerase | chr3:20012020-20016041 FORWARD [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • putative pasticcino 1 protein [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Peptidyl-prolyl isomerase PASTICCINO1 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) [nr-271106-contam.fasta]
  • PAS1 (PASTICCINO 1); FK506 binding / peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: PAS1, DEI1 | FKBP-type peptidyl-prolyl cis-trans isomerase family protein | chr3:20001042-20005063 FORWARD LENGTH=635 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 635 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    endoplasmic reticulum [IDA]
    Biological Process: embryonic development [IMP]
    root development [IMP]
    unidimensional cell growth [IMP]
    embryonic pattern specification [IMP]
    cell differentiation [IMP]
    establishment of cell polarity [IMP]
    very long-chain fatty acid biosynthetic process [IMP]
    response to cytokinin stimulus [IMP]
    lateral root development [IMP]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [ISS]
    FK506 binding [ISS]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVGDQTEQN YLPKKKKSET EDDKRRKKIV PGSLLKAVVR PGGGDSSPVD GDQVIYHCTV  60
   61 RTLDGVVVES TRSESGGRGV PIRDVLGNSK MILGLLEGIP TMHKGEIAMF KMKPEMHYAE 120
  121 IDCPVSAPEN FPKDDELHFE IELLDFSKAK IASDDLGVIK KILNEGEGWE SPREPYEVKA 180
  181 RISAKSGDGH VIFSHTEEPY FFTFGKSEVP KGLEIGIGTM ARKEKAVIYV RKQYLTESPL 240
  241 LHIDQDLEEV HFEVELVHFI QVRDMLGDGR LIKRRIRDGR GEFPMDCPLQ DSRLSVHYKG 300
  301 MLLNEEKTVF YDSKIDNNDQ PLEFSSGEGL VPEGFEMCTR LMLPGEIALV TCPPDYAYDK 360
  361 FPRPPGVSEG AHVQWEIELL GFETPRDWTG LNFQSIMDEA DKIRSTGNRL FKEGKFELAK 420
  421 AKYEKVLREF NHVNPQDEDE GKIFGDTRNM LHLNVAACLL KMGEWRKSIE TCNKVLEAKP 480
  481 GHVKGLYRRG MAYIAGGEYD DARNDFNMMI KVDKSSEADA TAALLKLKQK EQEAESKARK 540
  541 QFKGLFDKRP GEITEVGSEI REESKTIEEV DETKDNDDDE TLEEEGATTV STERKRKWSE 600
  601 KAWPFLKNVM LQIGIQLGVV LIGILIFQFV SAKFT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 52.69897 Crystal structure of N(1-260) of human FKBP52
    2 View Details [148..569] PSI-BLAST 60.154902 FKBP51, C-terminal domain; FKBP51, N-terminal domains
    3 View Details [570..635] PSI-BLAST 37.522879 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.39036685719765 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.20952794691357 bayes_pls_golite062009
  • macrolide binding
    		•  1.71427500929512 bayes_pls_golite062009
  • calcium channel activity
    		•  1.63210777407873 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • cation channel activity
    		•  1.60151579556523 bayes_pls_golite062009
  • FK506 binding
    		•  1.49236065710546 bayes_pls_golite062009
  • calcium-release channel activity
    		•  1.45042149123474 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • signal transducer activity
    		•  1.0856840943228 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.0856840943228 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • gated channel activity
    		•  0.960741819946338 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • ion channel activity
    		•  0.730166133387663 bayes_pls_golite062009
  • channel activity
    		•  0.713904534348638 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.713904534348638 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.704987652757674 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  0.405548038489461 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  0.405548038489461 bayes_pls_golite062009
  • receptor activity
    		•  0.39200463504884 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.327099943267853 bayes_pls_golite062009
  • transferase activity
    		•  0.31967318602798 bayes_pls_golite062009
  • kinase activity
    		•  0.301313235341922 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.237274026195605 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.225873481281805 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.13387993108257 bayes_pls_golite062009
  • protein kinase activity
    		•  0.102400286544695 bayes_pls_golite062009
  • protein binding
    		•  0.0371998661994551 bayes_pls_golite062009
    2
    Term Confidence Notes
  • procollagen-proline dioxygenase activity
    		•  4.85313532023068 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  4.85313532023068 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  4.85313532023068 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
    		•  4.85313532023068 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  3.50946031298682 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.39036685719765 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.20952794691357 bayes_pls_golite062009
  • DNA binding
    		•  1.77671451483154 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.72745783719415 bayes_pls_golite062009
  • macrolide binding
    		•  1.71427500929512 bayes_pls_golite062009
  • calcium channel activity
    		•  1.63210777407873 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • cation channel activity
    		•  1.60151579556523 bayes_pls_golite062009
  • FK506 binding
    		•  1.49236065710546 bayes_pls_golite062009
  • calcium-release channel activity
    		•  1.45042149123474 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.35268080101836 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.26630556032955 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.0856840943228 bayes_pls_golite062009
  • signal transducer activity
    		•  1.0856840943228 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • transcription factor activity
    		•  1.02820481637494 bayes_pls_golite062009
  • gated channel activity
    		•  0.960741819946338 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.780875583795532 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.761034574704448 bayes_pls_golite062009
  • ion channel activity
    		•  0.730166133387663 bayes_pls_golite062009
  • channel activity
    		•  0.713904534348638 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.713904534348638 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.704987652757674 bayes_pls_golite062009
  • transcription factor binding
    		•  0.498051196281179 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  0.405548038489461 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  0.405548038489461 bayes_pls_golite062009
  • receptor activity
    		•  0.39200463504884 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.327099943267853 bayes_pls_golite062009
  • transferase activity
    		•  0.31967318602798 bayes_pls_golite062009
  • kinase activity
    		•  0.301313235341922 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.24203289043804 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.237274026195605 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.225873481281805 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.13387993108257 bayes_pls_golite062009
  • protein kinase activity
    		•  0.102400286544695 bayes_pls_golite062009
  • protein binding
    		•  0.0371998661994551 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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