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Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule. Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein. Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: procollagen-proline 4-dioxygenase activity
Acc: GO:0004656
Aspect: Molecular Function
Desc: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.
Synonyms:
  • protocollagen hydroxylase activity
  • prolylprotocollagen dioxygenase activity
  • prolyl 4-hydroxylase activity
  • prolylprotocollagen hydroxylase activity
  • proline, 2-oxoglutarate dioxygenase activity
  • prolyl hydroxylase activity
  • prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity
  • proline hydroxylase activity
  • peptidyl proline hydroxylase activity
  • procollagen-proline,2-oxoglutarate-4-dioxygenase activity
  • proline protocollagen hydroxylase activity
  • protocollagen proline 4-hydroxylase activity
  • collagen proline hydroxylase activity
  • procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity
  • protocollagen proline dioxygenase activity
  • protocollagen proline hydroxylase activity
  • protocollagen prolyl hydroxylase activity
  • hydroxylase, collagen proline activity
  • proline,2-oxoglutarate 4-dioxygenase activity
Proteins in PDR annotated with:
   This term: 49 [Search]
   Term or descendants: 49 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004656 - procollagen-proline 4-dioxygenase activity (interactive image map)
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Created and Maintained by: Michael Riffle