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Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: peptidyl-proline 4-dioxygenase activity
Acc: GO:0031545
Aspect: Molecular Function
Desc: Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.
Synonyms:
  • prolyl 4-hydroxylase
  • HIF-type prolyl 4-hydroxylase
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 53 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031545 - peptidyl-proline 4-dioxygenase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle