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View Structure Prediction Details

Protein: PAS1_ARATH
Organism: Arabidopsis thaliana
Length: 635 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAS1_ARATH.

Description E-value Query
Range		 Subject
Range
gi|50947791, gi|... - gi|50947791|ref|XP_483423.1| putative 70 kDa peptidylprolyl isomerase [Oryza sativa (japonica cultiv...
 370.0 [0..25] [559..38]

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Predicted Domain #1
Region A:
Residues: [1-147] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVGDQTEQN YLPKKKKSET EDDKRRKKIV PGSLLKAVVR PGGGDSSPVD GDQVIYHCTV  60
   61 RTLDGVVVES TRSESGGRGV PIRDVLGNSK MILGLLEGIP TMHKGEIAMF KMKPEMHYAE 120
  121 IDCPVSAPEN FPKDDELHFE IELLDFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.69897
Match: 1q1cA
Description: Crystal structure of N(1-260) of human FKBP52
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidyl-prolyl cis-trans isomerase activity 4.0615867467963 bayes_pls_golite062009
cis-trans isomerase activity 3.99265212272703 bayes_pls_golite062009
ion transmembrane transporter activity 2.6566793500337 bayes_pls_golite062009
cation transmembrane transporter activity 2.61794461605199 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.47257819150887 bayes_pls_golite062009
transcription regulator activity 2.39036685719765 bayes_pls_golite062009
isomerase activity 2.31710030777753 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.20952794691357 bayes_pls_golite062009
macrolide binding 1.71427500929512 bayes_pls_golite062009
calcium channel activity 1.63210777407873 bayes_pls_golite062009
binding 1.63170667962375 bayes_pls_golite062009
cation channel activity 1.60151579556523 bayes_pls_golite062009
FK506 binding 1.49236065710546 bayes_pls_golite062009
calcium-release channel activity 1.45042149123474 bayes_pls_golite062009
drug binding 1.39643621593407 bayes_pls_golite062009
transporter activity 1.25197125648774 bayes_pls_golite062009
signal transducer activity 1.0856840943228 bayes_pls_golite062009
molecular transducer activity 1.0856840943228 bayes_pls_golite062009
transmembrane transporter activity 1.03909235910355 bayes_pls_golite062009
gated channel activity 0.960741819946338 bayes_pls_golite062009
catalytic activity 0.885282592863018 bayes_pls_golite062009
substrate-specific transporter activity 0.789390402522536 bayes_pls_golite062009
ion channel activity 0.730166133387663 bayes_pls_golite062009
channel activity 0.713904534348638 bayes_pls_golite062009
passive transmembrane transporter activity 0.713904534348638 bayes_pls_golite062009
substrate-specific channel activity 0.704987652757674 bayes_pls_golite062009
ryanodine-sensitive calcium-release channel activity 0.405548038489461 bayes_pls_golite062009
intracellular ligand-gated calcium channel activity 0.405548038489461 bayes_pls_golite062009
receptor activity 0.39200463504884 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.327099943267853 bayes_pls_golite062009
transferase activity 0.31967318602798 bayes_pls_golite062009
kinase activity 0.301313235341922 bayes_pls_golite062009
unfolded protein binding 0.27473817613726 bayes_pls_golite062009
transmembrane receptor activity 0.237274026195605 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.225873481281805 bayes_pls_golite062009
transcription elongation regulator activity 0.13387993108257 bayes_pls_golite062009
protein kinase activity 0.102400286544695 bayes_pls_golite062009
protein binding 0.0371998661994551 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [148-569] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAKIASDDLG VIKKILNEGE GWESPREPYE VKARISAKSG DGHVIFSHTE EPYFFTFGKS  60
   61 EVPKGLEIGI GTMARKEKAV IYVRKQYLTE SPLLHIDQDL EEVHFEVELV HFIQVRDMLG 120
  121 DGRLIKRRIR DGRGEFPMDC PLQDSRLSVH YKGMLLNEEK TVFYDSKIDN NDQPLEFSSG 180
  181 EGLVPEGFEM CTRLMLPGEI ALVTCPPDYA YDKFPRPPGV SEGAHVQWEI ELLGFETPRD 240
  241 WTGLNFQSIM DEADKIRSTG NRLFKEGKFE LAKAKYEKVL REFNHVNPQD EDEGKIFGDT 300
  301 RNMLHLNVAA CLLKMGEWRK SIETCNKVLE AKPGHVKGLY RRGMAYIAGG EYDDARNDFN 360
  361 MMIKVDKSSE ADATAALLKL KQKEQEAESK ARKQFKGLFD KRPGEITEVG SEIREESKTI 420
  421 EE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.154902
Match: 1kt0A
Description: FKBP51, C-terminal domain; FKBP51, N-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
procollagen-proline dioxygenase activity 4.85313532023068 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 4.85313532023068 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 4.85313532023068 bayes_pls_golite062009
procollagen-proline 4-dioxygenase activity 4.85313532023068 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 4.0615867467963 bayes_pls_golite062009
cis-trans isomerase activity 3.99265212272703 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 3.50946031298682 bayes_pls_golite062009
ion transmembrane transporter activity 2.6566793500337 bayes_pls_golite062009
cation transmembrane transporter activity 2.61794461605199 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.47257819150887 bayes_pls_golite062009
transcription regulator activity 2.39036685719765 bayes_pls_golite062009
isomerase activity 2.31710030777753 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.20952794691357 bayes_pls_golite062009
DNA binding 1.77671451483154 bayes_pls_golite062009
nucleic acid binding 1.72745783719415 bayes_pls_golite062009
macrolide binding 1.71427500929512 bayes_pls_golite062009
calcium channel activity 1.63210777407873 bayes_pls_golite062009
binding 1.63170667962375 bayes_pls_golite062009
cation channel activity 1.60151579556523 bayes_pls_golite062009
FK506 binding 1.49236065710546 bayes_pls_golite062009
calcium-release channel activity 1.45042149123474 bayes_pls_golite062009
drug binding 1.39643621593407 bayes_pls_golite062009
heat shock protein binding 1.35268080101836 bayes_pls_golite062009
steroid hormone receptor binding 1.26630556032955 bayes_pls_golite062009
transporter activity 1.25197125648774 bayes_pls_golite062009
molecular transducer activity 1.0856840943228 bayes_pls_golite062009
signal transducer activity 1.0856840943228 bayes_pls_golite062009
transmembrane transporter activity 1.03909235910355 bayes_pls_golite062009
transcription factor activity 1.02820481637494 bayes_pls_golite062009
gated channel activity 0.960741819946338 bayes_pls_golite062009
catalytic activity 0.885282592863018 bayes_pls_golite062009
substrate-specific transporter activity 0.789390402522536 bayes_pls_golite062009
hormone receptor binding 0.780875583795532 bayes_pls_golite062009
nuclear hormone receptor binding 0.761034574704448 bayes_pls_golite062009
ion channel activity 0.730166133387663 bayes_pls_golite062009
channel activity 0.713904534348638 bayes_pls_golite062009
passive transmembrane transporter activity 0.713904534348638 bayes_pls_golite062009
substrate-specific channel activity 0.704987652757674 bayes_pls_golite062009
transcription factor binding 0.498051196281179 bayes_pls_golite062009
ryanodine-sensitive calcium-release channel activity 0.405548038489461 bayes_pls_golite062009
intracellular ligand-gated calcium channel activity 0.405548038489461 bayes_pls_golite062009
receptor activity 0.39200463504884 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.327099943267853 bayes_pls_golite062009
transferase activity 0.31967318602798 bayes_pls_golite062009
kinase activity 0.301313235341922 bayes_pls_golite062009
unfolded protein binding 0.27473817613726 bayes_pls_golite062009
transcription cofactor activity 0.24203289043804 bayes_pls_golite062009
transmembrane receptor activity 0.237274026195605 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.225873481281805 bayes_pls_golite062009
transcription elongation regulator activity 0.13387993108257 bayes_pls_golite062009
protein kinase activity 0.102400286544695 bayes_pls_golite062009
protein binding 0.0371998661994551 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [570-635] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDETKDNDDD ETLEEEGATT VSTERKRKWS EKAWPFLKNV MLQIGIQLGV VLIGILIFQF  60
   61 VSAKFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.522879
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle