YRC Public Data Repository - Protein Structure Prediction

Protein:	YEJF_ECOLI
Organism:	Escherichia coli
Length:	529 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEJF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|14025332, gi\|... - gi\|14025332\|dbj\|BAB51933.1\| peptide ABC transporter, ATP-binding protein [Mesorhizobium loti MAFF303...	582.0	[0..1]	[529..1]
gi\|86165473, gi\|... - gi\|87119082\|ref\|ZP_01074980.1\| ABC transporter, ATP-binding protein [Marinomonas sp. MED121], gi\|861...	579.0	[0..1]	[529..1]
gi\|151938703, gi... - gi\|75855978\|ref\|ZP_00763615.1\| COG4172: ABC-type uncharacterized transport system, duplicated ATPase...	577.0	[0..2]	[529..3]
gi\|91192063, gi\|... - gi\|91223250\|ref\|ZP_01258516.1\| ABC transporter, ATP-binding protein [Vibrio alginolyticus 12G01], gi...	577.0	[0..2]	[529..3]
gi\|15073081 - gi\|15073081\|emb\|CAC41540.1\| PUTATIVE ATP-BINDING ABC TRANSPORTER PROTEIN [Sinorhizobium meliloti] gi\|15963906 - gi\|15963906\|ref\|NP_384259.1\| PUTATIVE ATP-BINDING ABC TRANSPORTER PROTEIN [Sinorhizobium meliloti 10...	575.0	[0..1]	[529..5]
gi\|116249955, gi... - gi\|116249955\|ref\|YP_765793.1\| putative ATP-binding component of ABC transporter [Rhizobium leguminos...	575.0	[0..1]	[529..4]
gi\|86355838, gi\|... - gi\|86355838\|ref\|YP_467730.1\| peptide ABC transporter, ATP binding protein [Rhizobium etli CFN 42], g...	574.0	[0..1]	[529..1]
gi\|254222729, gi... - gi\|75824841\|ref\|ZP_00754285.1\| COG4172: ABC-type uncharacterized transport system, duplicated ATPase... tr\|A0A085TER9\|A0... - Nickel import ATP-binding protein NikE OS=Vibrio cholerae GN=nikE PE=4 SV=1, ABC transporter OS=Vibr...	573.0	[0..1]	[529..1]
gi\|69278434, gi\|... - gi\|69278434\|ref\|ZP_00613540.1\| ABC transporter [Mesorhizobium sp. BNC1], gi\|68190663\|gb\|EAN05321.1\| ...	572.0	[0..1]	[529..1]
gi\|227812543, gi... - gi\|227812543\|ref\|YP_002812553.1\| ABC transporter, ATP-binding protein [Vibrio cholerae M66-2], gi\|22... gi\|15601730, gi\|... - gi\|9658417\|gb\|AAF96873.1\| ABC transporter, ATP-binding protein [Vibrio cholerae O1 biovar eltor str.... gi\|75831404, gi\|... - gi\|75831404\|ref\|ZP_00760668.1\| COG4172: ABC-type uncharacterized transport system, duplicated ATPase... gi\|75825172, gi\|... - gi\|75825172\|ref\|ZP_00754608.1\| COG4172: ABC-type uncharacterized transport system, duplicated ATPase... gi\|121549094, gi... - gi\|121587007\|ref\|ZP_01676785.1\| ABC transporter, ATP-binding protein [Vibrio cholerae 2740-80], gi\|1... gi\|153221678, gi... - gi\|153221678\|ref\|ZP_01952583.1\| ABC transporter, ATP-binding protein [Vibrio cholerae MAK 757], gi\|1... gi\|11354361 - pir\|\|B82393 ABC transporter, ATP-binding protein VCA0977 [imported] - Vibrio cholerae (strain N16961... gi\|126511281, gi... - gi\|153818175\|ref\|ZP_01970842.1\| ABC transporter, ATP-binding protein [Vibrio cholerae NCTC 8457], gi... gi\|229605419, gi... - gi\|229605419\|ref\|YP_002876123.1\| ABC transporter ATP-binding protein [Vibrio cholerae MJ-1236], gi\|2... gi\|229345647, gi... - gi\|229517611\|ref\|ZP_04407056.1\| ABC transporter ATP-binding protein [Vibrio cholerae RC9], gi\|229345... gi\|229352705, gi... - gi\|229510260\|ref\|ZP_04399740.1\| ABC transporter ATP-binding protein [Vibrio cholerae B33], gi\|229352... gi\|229356238, gi... - gi\|229505887\|ref\|ZP_04395396.1\| ABC transporter ATP-binding protein [Vibrio cholerae BX 330286], gi\|...	572.0	[0..1]	[529..1]

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Predicted Domain #1

Region A:
Residues: [1-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQTLLAIEN LSVGFRHQQT VRTVVNDVSL QIEAGETLAL VGESGSGKSV TALSILRLLP  60
   61 SPPVEYLSGD IRFHGESLLH ASDQTLRGVR GNKIAMIFQE PMVSLNPLHT LEKQLYEVLS 120
  121 LHRGMRREAA RGEILNCLDR VGIRQAAKRL TDYPHQLSGG ERQRVMIAMA LLTRPELLIA 180
  181 DEPTTALDVS VQAQILQLLR ELQGELNMGM LFITHNLSIV RKLAHRVAVM QNGRCVEQNY 240
  241 AATLFASPTH PYTQKLLNSE PSGDPVPLPE PASTLLDVEQ LQVAFPIRKG ILKRIVDHNV 300
  301 VVKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.154902
Match:	1q1bA
Description:	Crystal structure of E. coli MalK in the nucleotide-free form
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.58863529263644	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.58067278719409	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.57974651657836	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.57922174989907	bayes_pls_golite062009
primary active transmembrane transporter activity	6.57807080367604	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.48406410175216	bayes_pls_golite062009
active transmembrane transporter activity	6.48154954364331	bayes_pls_golite062009
pyrophosphatase activity	6.40467109535527	bayes_pls_golite062009
ATPase activity, coupled	6.40151534181487	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.38373914253885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.38247436082206	bayes_pls_golite062009
ATPase activity	6.30019941712404	bayes_pls_golite062009
heme transporter activity	4.82479229680991	bayes_pls_golite062009
peptide transporter activity	4.7442815698413	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.71935767060308	bayes_pls_golite062009
peptide-transporting ATPase activity	4.63590351019108	bayes_pls_golite062009
hydrolase activity	4.60957912556603	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	4.35344629015015	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	4.18204040663138	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	4.18204040663138	bayes_pls_golite062009
oligopeptide-transporting ATPase activity	4.09365342567844	bayes_pls_golite062009
ribonucleotide binding	3.79710854336074	bayes_pls_golite062009
purine ribonucleotide binding	3.7956093726294	bayes_pls_golite062009
ATP binding	3.78352939926331	bayes_pls_golite062009
purine nucleotide binding	3.74676466237472	bayes_pls_golite062009
adenyl ribonucleotide binding	3.73153142187361	bayes_pls_golite062009
nucleotide binding	3.71970404557651	bayes_pls_golite062009
adenyl nucleotide binding	3.66815111788068	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	3.20894563245332	bayes_pls_golite062009
phosphate transmembrane transporter activity	3.14373643903738	bayes_pls_golite062009
anion transmembrane transporter activity	3.13913638619234	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.9271291809464	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.63419811368692	bayes_pls_golite062009
cofactor transporter activity	2.41442360192472	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.26365379756656	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
oligopeptide transporter activity	2.05580564974083	bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity	1.92426772294655	bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity	1.92426772294655	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
polysaccharide transmembrane transporter activity	1.87680514870933	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
binding	1.78141737095177	bayes_pls_golite062009
organic anion transmembrane transporter activity	1.76999970080179	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
sugar transmembrane transporter activity	1.57734504779864	bayes_pls_golite062009
phosphonate transmembrane transporter activity	1.40269234722336	bayes_pls_golite062009
carbohydrate-transporting ATPase activity	1.37859980472197	bayes_pls_golite062009
carbohydrate-importing ATPase activity	1.27327946933978	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	1.1220946941463	bayes_pls_golite062009
dipeptide transporter activity	1.01130176523309	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
cation channel activity	0.997064416395892	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
potassium channel activity	0.843657228494419	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
voltage-gated cation channel activity	0.688632087597536	bayes_pls_golite062009
voltage-gated channel activity	0.562664200036023	bayes_pls_golite062009
voltage-gated ion channel activity	0.559798751382976	bayes_pls_golite062009
DNA-dependent ATPase activity	0.50574216781413	bayes_pls_golite062009
signal transducer activity	0.501012663775049	bayes_pls_golite062009
molecular transducer activity	0.501012663775049	bayes_pls_golite062009
protein transporter activity	0.498432226280822	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	0.483217496906356	bayes_pls_golite062009
kinase activity	0.465336251595641	bayes_pls_golite062009
glucoside transmembrane transporter activity	0.31429820040527	bayes_pls_golite062009
maltose transmembrane transporter activity	0.309333293394255	bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity	0.309333293394255	bayes_pls_golite062009
disaccharide transmembrane transporter activity	0.309333293394255	bayes_pls_golite062009
oligosaccharide transmembrane transporter activity	0.304521826432814	bayes_pls_golite062009
oligosaccharide-transporting ATPase activity	0.304521826432814	bayes_pls_golite062009
maltose-transporting ATPase activity	0.304521826432814	bayes_pls_golite062009
gated channel activity	0.299411774392227	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.219473333671469	bayes_pls_golite062009
cholesterol transporter activity	0.20165628585345	bayes_pls_golite062009
protein kinase activity	0.194459978373898	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
vitamin transporter activity	0.162731691286377	bayes_pls_golite062009
ion channel activity	0.154779598791225	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
channel activity	0.134817721656507	bayes_pls_golite062009
passive transmembrane transporter activity	0.134817721656507	bayes_pls_golite062009
substrate-specific channel activity	0.126911677161968	bayes_pls_golite062009
nucleic acid binding	0.12562572048621	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [305-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISFTLRAGET LGLVGESGSG KSTTGLALLR LINSQGSIIF DGQPLQNLNR RQLLPIRHRI  60
   61 QVVFQDPNSS LNPRLNVLQI IEEGLRVHQP TLSAAQREQQ VIAVMHEVGL DPETRHRYPA 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.54
Match:	1l2tA
Description:	MJ0796
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.35679785959905	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.34882895187645	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.34796119059391	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.34752301831093	bayes_pls_golite062009
primary active transmembrane transporter activity	6.34682445431563	bayes_pls_golite062009
active transmembrane transporter activity	6.2644721575242	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.20825723945673	bayes_pls_golite062009
ATPase activity, coupled	6.15556401756153	bayes_pls_golite062009
pyrophosphatase activity	6.13290657318533	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.11304466429837	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.11183900571839	bayes_pls_golite062009
ATPase activity	6.04976042932218	bayes_pls_golite062009
heme transporter activity	4.65227896386767	bayes_pls_golite062009
peptide transporter activity	4.56203793750776	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.55280710570334	bayes_pls_golite062009
hydrolase activity	4.43520071189394	bayes_pls_golite062009
peptide-transporting ATPase activity	4.4271444450371	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	4.21025659649908	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	4.07738180396862	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	4.07738180396862	bayes_pls_golite062009
oligopeptide-transporting ATPase activity	3.89334019013497	bayes_pls_golite062009
ATP binding	3.59387357478212	bayes_pls_golite062009
ribonucleotide binding	3.5791729478419	bayes_pls_golite062009
purine ribonucleotide binding	3.57762539334739	bayes_pls_golite062009
adenyl ribonucleotide binding	3.5444160681603	bayes_pls_golite062009
purine nucleotide binding	3.53100851170668	bayes_pls_golite062009
nucleotide binding	3.50565598357459	bayes_pls_golite062009
adenyl nucleotide binding	3.48445936077373	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.43376764510244	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.39040720727162	bayes_pls_golite062009
ion transmembrane transporter activity	3.28894636799771	bayes_pls_golite062009
cation transmembrane transporter activity	3.03916263027565	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	3.02918058007208	bayes_pls_golite062009
anion transmembrane transporter activity	2.99692914804199	bayes_pls_golite062009
phosphate transmembrane transporter activity	2.98876196314831	bayes_pls_golite062009
iron ion transmembrane transporter activity	2.97738411659502	bayes_pls_golite062009
transporter activity	2.9325438450934	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.85700422348608	bayes_pls_golite062009
drug transmembrane transporter activity	2.82660507491961	bayes_pls_golite062009
transmembrane transporter activity	2.77909183361556	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.68430060119143	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.55775782483172	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.52006943992903	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.51747025967062	bayes_pls_golite062009
amine-transporting ATPase activity	2.51506519090711	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.3376945192254	bayes_pls_golite062009
cofactor transporter activity	2.29822034187524	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.24296079037576	bayes_pls_golite062009
amine transmembrane transporter activity	2.13810736746547	bayes_pls_golite062009
	2.06939970453264	bayes_pls_golite062009
oligopeptide transporter activity	1.89162361038123	bayes_pls_golite062009
substrate-specific transporter activity	1.8085602148752	bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity	1.80523541517335	bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity	1.80523541517335	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.73700692433997	bayes_pls_golite062009
polysaccharide transmembrane transporter activity	1.73222131384038	bayes_pls_golite062009
binding	1.71761116975383	bayes_pls_golite062009
organic anion transmembrane transporter activity	1.59731430941388	bayes_pls_golite062009
sugar transmembrane transporter activity	1.47251677946834	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.42375749611671	bayes_pls_golite062009
phosphonate transmembrane transporter activity	1.28127412362388	bayes_pls_golite062009
carbohydrate-transporting ATPase activity	1.2628060222463	bayes_pls_golite062009
carbohydrate-importing ATPase activity	1.16583878561944	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.12292194267086	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	1.03817369905388	bayes_pls_golite062009
cation channel activity	1.01473387312188	bayes_pls_golite062009
catalytic activity	0.942640875796745	bayes_pls_golite062009
dipeptide transporter activity	0.938623643191976	bayes_pls_golite062009
potassium channel activity	0.857553691679628	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.709723874471825	bayes_pls_golite062009
voltage-gated cation channel activity	0.678735754814463	bayes_pls_golite062009
motor activity	0.667438950259944	bayes_pls_golite062009
GTPase activity	0.603004420222648	bayes_pls_golite062009
voltage-gated channel activity	0.558948315575652	bayes_pls_golite062009
voltage-gated ion channel activity	0.555516847169798	bayes_pls_golite062009
molecular transducer activity	0.553626670981749	bayes_pls_golite062009
signal transducer activity	0.553626670981749	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	0.479582513098201	bayes_pls_golite062009
kinase activity	0.460784051995763	bayes_pls_golite062009
protein transporter activity	0.406008298719309	bayes_pls_golite062009
gated channel activity	0.321731680865208	bayes_pls_golite062009
DNA-dependent ATPase activity	0.291677727438101	bayes_pls_golite062009
glucoside transmembrane transporter activity	0.286079234973646	bayes_pls_golite062009
maltose transmembrane transporter activity	0.277935324219913	bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity	0.277935324219913	bayes_pls_golite062009
disaccharide transmembrane transporter activity	0.277935324219913	bayes_pls_golite062009
oligosaccharide-transporting ATPase activity	0.26953844856094	bayes_pls_golite062009
maltose-transporting ATPase activity	0.26953844856094	bayes_pls_golite062009
oligosaccharide transmembrane transporter activity	0.26953844856094	bayes_pls_golite062009
protein kinase activity	0.234341066259735	bayes_pls_golite062009
protein binding	0.224801331525112	bayes_pls_golite062009
ion channel activity	0.17671388431308	bayes_pls_golite062009
passive transmembrane transporter activity	0.164130750223518	bayes_pls_golite062009
channel activity	0.164130750223518	bayes_pls_golite062009
substrate-specific channel activity	0.154272377180496	bayes_pls_golite062009
vitamin transporter activity	0.146223090752716	bayes_pls_golite062009
nucleic acid binding	0.0973947759569709	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.0699419840485205	bayes_pls_golite062009
cholesterol transporter activity	0.0640896715391173	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	3.52771486874626E-4	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [425-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFSGGQRQRI AIARALILKP SLIILDEPTS SLDKTVQAQI LTLLKSLQQK HQLAYLFISH  60
   61 DLHVVRALCH QVIILRQGEV VEQGPCARVF ATPQQEYTRQ LLALS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.522879
Match:	1z47A
Description:	Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: