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View Structure Prediction Details

Protein: cdk9
Organism: Schizosaccharomyces pombe
Length: 591 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdk9.

Description E-value Query
Range		 Subject
Range
gi|15215944 - gi|15215944|emb|CAC51391.1| cyclin dependent kinase C [Solanum lycopersicum]
 310.0 [0..22] [516..11]
gi|73966111 - gi|73966111|ref|XP_863931.1| PREDICTED: similar to Cell division cycle 2-related protein kinase 7 (C...
 309.0 [0..26] [577..17]
gi|55977994 - gi|55977994|gb|AAV68597.1| cell cycle dependent kinase C [Ostreococcus tauri]
 304.0 [0..2] [452..23]
gi|37927357 - gi|37927357|pdb|1OZ1|A Chain A, P38 Mitogen-Activated Kinase In Complex With 4-Azaindole Inhibitor
 302.0 [0..1] [391..1]
MPK14_ORYSA - Mitogen-activated protein kinase 14 (EC 2.7.11.24) (MAP kinase 14) - Oryza sativa (Rice)
MPK14_ORYSJ - Mitogen-activated protein kinase 14 OS=Oryza sativa subsp. japonica GN=MPK14 PE=2 SV=1
 301.0 [0..26] [581..3]
gi|2914479, gi|1... - gi|2914479|pdb|1P38| Chain , The Structure Of The Map Kinase P38 At 2.1 Angstoms Resolution, gi|15...
gi|5821849 - gi|5821849|pdb|1BMK|A Chain A, The Complex Structure Of The Map Kinase P38SB218655
 300.0 [0..7] [391..14]
gi|49671277, gi|... - gi|54262236|ref|NP_001005824.1| mitogen-activated protein kinase 14 [Xenopus (Silurana) tropicalis],...
 300.0 [0..13] [391..2]

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Predicted Domain #1
Region A:
Residues: [1-379] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRSSSVSVE DEKSARRKLD VVPKLHFVGC SHLTDYHLME KLGEGTFGEV YKSQRRKDGK  60
   61 VYALKRILMH TEKEGFPITA IREIKILKSI KHENIIPLSD MTVVRADKKH RRRGSIYMVT 120
  121 PYMDHDLSGL LENPSVKFTE PQIKCYMKQL FAGTKYLHDQ LILHRDLKAA NLLIDNHGIL 180
  181 KIADFGLARV ITEESYANKN PGLPPPNRRE YTGCVVTRWY RSPELLLGER RYTTAIDMWS 240
  241 VGCIMAEMYK GRPILQGSSD LDQLDKIFRL CGSPTQATMP NWEKLPGCEG VRSFPSHPRT 300
  301 LETAFFTFGK EMTSLCGAIL TLNPDERLSA SMALEHEYFT TPPYPANPSE LQSYSASHEY 360
  361 DKRRKREQRD ANSHAFEQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.39794
Match: 1vywA
Description: Structure of CDK2/Cyclin A with PNU-292137
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine receptor activator activity 5.9159846946654 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
transcription elongation regulator activity 4.93646793786886 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
MAP kinase 2 activity 3.27009208121248 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.79505438761262 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 2.30873410607588 bayes_pls_golite062009
transforming growth factor beta receptor activity 2.30873410607588 bayes_pls_golite062009
histone kinase activity (H3-S10 specific) 2.30449166929476 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 1.74645334586495 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
activin binding 1.69795678545106 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.66976264488423 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
activin receptor activity 1.64506335968643 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.60259443694567 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.03605423743048 bayes_pls_golite062009
SMAD binding 1.02108562119195 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
fibroblast growth factor binding 0.870666814073948 bayes_pls_golite062009
activin receptor activity, type I 0.82317428935631 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
receptor serine/threonine kinase binding 0.728917900114111 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
transforming growth factor beta receptor binding 0.705634826374884 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 0.705634826374884 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
beta-catenin binding 0.693246095477001 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transforming growth factor beta binding 0.435457844706269 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.149958560815481 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.149958560815481 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.14842991990838 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.0794053647730006 bayes_pls_golite062009
nitric-oxide synthase regulator activity 0.00407218246327123 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [380-591] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANGKRQFRFM TRGPSDPWYG IRRPNYNSQP QYQRGSYNRE GGNMDRSRNV NYQPKRQQNF  60
   61 KPLTSDLPQK NSEFSETNAM NQTSNHSHAD GQRYYRPEQD RSQRLRNPSD YGRQGRQSSQ 120
  121 SQQPAWNVSS RYQNNSKVQT TSRASENADT NKTQHNIKYI DSYVPEYSIA RQSANQKTNE 180
  181 QHPSSTSLHQ QSTSDLKSPS FHENSNVDDT PK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle