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View Structure Prediction Details

Protein: ABCB4
Organism: Homo sapiens
Length: 1286 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ABCB4.

Description E-value Query
Range		 Subject
Range
gi|114614720 - gi|114614720|ref|XP_001160982.1| PREDICTED: ATP-binding cassette, subfamily B, member 4 [Pan troglod...
 0.0 [1..1280] [313..1585]
gi|71052059 - gi|71052059|gb|AAH42531.1| ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Homo sapiens]
 0.0 [1..1286] [1..1286]
MDR2_MOUSE - Multidrug resistance protein 2 OS=Mus musculus GN=Abcb4 PE=2 SV=1
 0.0 [1..1286] [1..1276]
gi|57526446, gi|... - gi|57526446|ref|NP_001009790.1| ATP-binding cassette, subfamily B, member 1 [Ovis aries], gi|2149087...
 0.0 [1..1285] [1..1284]
gi|60326712 - gi|60326712|gb|AAX18881.1| P-glycoprotein [Cercopithecus aethiops]
 0.0 [1..1285] [1..1279]
MDR3_CRIGR - Phosphatidylcholine translocator ABCB4 OS=Cricetulus griseus GN=ABCB4 PE=2 SV=1
 0.0 [1..1285] [1..1280]
gi|191155 - gi|191155|gb|AAA37004.1| p-glycoprotein
gi|72477 - pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
 0.0 [40..1285] [33..1276]

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Predicted Domain #1
Region A:
Residues: [1-677] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD WQDKLFMSLG  60
   61 TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL SLLNPGKILE EEMTRYAYYY 120
  121 SGLGAGVLVA AYIQVSFWTL AAGRQIRKIR QKFFHAILRQ EIGWFDINDT TELNTRLTDD 180
  181 ISKISEGIGD KVGMFFQAVA TFFAGFIVGF IRGWKLTLVI MAISPILGLS AAVWAKILSA 240
  241 FSDKELAAYA KAGAVAEEAL GAIRTVIAFG GQNKELERYQ KHLENAKEIG IKKAISANIS 300
  301 MGIAFLLIYA SYALAFWYGS TLVISKEYTI GNAMTVFFSI LIGAFSVGQA APCIDAFANA 360
  361 RGAAYVIFDI IDNNPKIDSF SERGHKPDSI KGNLEFNDVH FSYPSRANVK ILKGLNLKVQ 420
  421 SGQTVALVGS SGCGKSTTVQ LIQRLYDPDE GTINIDGQDI RNFNVNYLRE IIGVVSQEPV 480
  481 LFSTTIAENI CYGRGNVTMD EIKKAVKEAN AYEFIMKLPQ KFDTLVGERG AQLSGGQKQR 540
  541 IAIARALVRN PKILLLDEAT SALDTESEAE VQAALDKARE GRTTIVIAHR LSTVRNADVI 600
  601 AGFEDGVIVE QGSHSELMKK EGVYFKLVNM QTSGSQIQSE EFELNDEKAA TRMAPNGWKS 660
  661 RLFRHSTQKN LKNSQMC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 140.0
Match: 2hydA
Description: No description for 2hydA was found.

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 2.57684108006744 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 2.33958437214304 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
L-aspartate transmembrane transporter activity 2.05274761921715 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
binding 1.69327117652379 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity 1.37836402136387 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
bile acid transmembrane transporter activity 0.687612064139871 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
nucleic acid binding 0.144904409289829 bayes_pls_golite062009
microtubule motor activity 0.11674780318211 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
oligopeptide transporter activity 0.0268154844251251 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [678-1031] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKSLDVETDG LEANVPPVSF LKVLKLNKTE WPYFVVGTVC AIANGGLQPA FSVIFSEIIA  60
   61 IFGPGDDAVK QQKCNIFSLI FLFLGIISFF TFFLQGFTFG KAGEILTRRL RSMAFKAMLR 120
  121 QDMSWFDDHK NSTGALSTRL ATDAAQVQGA TGTRLALIAQ NIANLGTGII ISFIYGWQLT 180
  181 LLLLAVVPII AVSGIVEMKL LAGNAKRDKK ELEAAGKIAT EAIENIRTVV SLTQERKFES 240
  241 MYVEKLYGPY RNSVQKAHIY GITFSISQAF MYFSYAGCFR FGAYLIVNGH MRFRDVILVF 300
  301 SAIVFGAVAL GHASSFAPDY AKAKLSAAHL FMLFERQPLI DSYSEEGLKP DKFE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.4
Match: 2hydA
Description: No description for 2hydA was found.

Predicted functions:

Term Confidence Notes
lipid transporter activity 6.95325922226092 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.4467861893359 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.44654566127945 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.44654566127945 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.43909190876515 bayes_pls_golite062009
primary active transmembrane transporter activity 5.4304944906989 bayes_pls_golite062009
active transmembrane transporter activity 5.38112407181712 bayes_pls_golite062009
ATPase activity, coupled 4.87869064889244 bayes_pls_golite062009
ATPase activity 4.60773943958528 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.38591214726007 bayes_pls_golite062009
pyrophosphatase activity 4.32673473878039 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.31087891816858 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.31037981322306 bayes_pls_golite062009
transporter activity 3.47953169973151 bayes_pls_golite062009
hydrolase activity 3.11706952898443 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.96171085039592 bayes_pls_golite062009
transmembrane transporter activity 2.94175800357966 bayes_pls_golite062009
substrate-specific transporter activity 2.90743799425416 bayes_pls_golite062009
ATP binding 2.83986218503994 bayes_pls_golite062009
adenyl ribonucleotide binding 2.79195527951815 bayes_pls_golite062009
adenyl nucleotide binding 2.74359323245512 bayes_pls_golite062009
purine ribonucleotide binding 2.55506944753783 bayes_pls_golite062009
ribonucleotide binding 2.55426312645972 bayes_pls_golite062009
purine nucleotide binding 2.51344800975739 bayes_pls_golite062009
nucleotide binding 2.48057252852174 bayes_pls_golite062009
binding 1.66695393603756 bayes_pls_golite062009
catalytic activity 0.372934161904337 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [1032-1286] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNITFNEVVF NYPTRANVPV LQGLSLEVKK GQTLALVGSS GCGKSTVVQL LERFYDPLAG  60
   61 TVFVDFGFQL LDGQEAKKLN VQWLRAQLGI VSQEPILFDC SIAENIAYGD NSRVVSQDEI 120
  121 VSAAKAANIH PFIETLPHKY ETRVGDKGTQ LSGGQKQRIA IARALIRQPQ ILLLDEATSA 180
  181 LDTESEKVVQ EALDKAREGR TCIVIAHRLS TIQNADLIVV FQNGRVKEHG THQQLLAQKG 240
  241 IYFSMVSVQA GTQNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.0
Match: 1mt0A
Description: Haemolysin B ATP-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
lipid transporter activity 3.14635082108971 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 2.57684108006744 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 2.33958437214304 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
L-aspartate transmembrane transporter activity 2.05274761921715 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity 1.37836402136387 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
bile acid transmembrane transporter activity 0.687612064139871 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
nucleic acid binding 0.144904409289829 bayes_pls_golite062009
microtubule motor activity 0.11674780318211 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
oligopeptide transporter activity 0.0268154844251251 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle