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View Structure Prediction Details

Protein: FYN
Organism: Homo sapiens
Length: 537 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FYN.

Description E-value Query
Range		 Subject
Range
gi|61652774 - gi|61652774|gb|AAX47959.1| Fyn Kinase [Danio rerio]
 0.0 [1..537] [1..537]
gi|338228 - gi|338228|gb|AAA36615.1| src-like tyrosine kinase (put.); putative
 0.0 [1..537] [1..537]
FYN_XIPHE - Tyrosine-protein kinase Fyn OS=Xiphophorus helleri GN=fyn PE=2 SV=3
 0.0 [1..537] [1..537]
gi|73973786 - gi|73973786|ref|XP_854467.1| PREDICTED: similar to fyn proto-oncogene isoform 2 [Canis familiaris]
gi|149722885 - gi|149722885|ref|XP_001504099.1| PREDICTED: similar to FYN oncogene related to SRC, FGR, YES [Equus ...
ENSCJAT00000009541 - null
tr|M3X148|M3X148... - Tyrosine-protein kinase OS=Felis catus GN=FYN PE=3 SV=1
 0.0 [1..537] [1..537]
gi|109073003 - gi|109073003|ref|XP_001085015.1| PREDICTED: protein-tyrosine kinase fyn [Macaca mulatta]
 0.0 [1..537] [1..537]
FYN_BOVIN - Tyrosine-protein kinase Fyn OS=Bos taurus GN=FYN PE=2 SV=1
 0.0 [1..537] [1..537]
gi|117616364 - gi|117616364|gb|ABK42200.1| Fyn [synthetic construct]
FYN_MOUSE - Tyrosine-protein kinase Fyn OS=Mus musculus GN=Fyn PE=1 SV=4
 0.0 [1..537] [1..537]
FYN_RAT - Tyrosine-protein kinase Fyn OS=Rattus norvegicus GN=Fyn PE=1 SV=1
gi|126310436 - gi|126310436|ref|XP_001368891.1| PREDICTED: similar to FYN oncogene related to SRC, FGR, YES isoform...
 0.0 [1..537] [1..537]
FYN_XENLA - Tyrosine-protein kinase Fyn OS=Xenopus laevis GN=fyn PE=2 SV=3
 0.0 [1..537] [1..537]

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Predicted Domain #1
Region A:
Residues: [1-537] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG  60
   61 LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120
  121 EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180
  181 TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240
  241 RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300
  301 LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360
  361 ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420
  421 TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480
  481 RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 116.0
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
CD8 receptor binding 4.05356115367695 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
erythropoietin receptor binding 3.89714169376776 bayes_pls_golite062009
phosphoinositide 3-kinase binding 3.43994026029707 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
PTB domain binding 3.37370070512378 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 3.26784640416242 bayes_pls_golite062009
transmembrane receptor activity 3.1965684217331 bayes_pls_golite062009
SH2 domain binding 3.03401803018883 bayes_pls_golite062009
epidermal growth factor receptor binding 2.9751846707539 bayes_pls_golite062009
receptor activity 2.96273889901429 bayes_pls_golite062009
signal transducer activity 2.85730457922199 bayes_pls_golite062009
molecular transducer activity 2.85730457922199 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.52273333081659 bayes_pls_golite062009
insulin receptor activity 2.48320803030481 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
insulin-like growth factor receptor binding 2.18795259566024 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 2.1677218320705 bayes_pls_golite062009
transforming growth factor beta receptor activity 2.1677218320705 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
insulin binding 2.0719180171079 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.93826393981131 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
amine binding 1.88718396958192 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.66669268613198 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
vinculin binding 1.63216315345235 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
cytokine receptor binding 1.55071552871145 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
cation channel activity 1.38878809769275 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
activin binding 1.22461306010416 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
ErbB-2 class receptor binding 1.06651320735249 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 1.03150090191995 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
channel activity 0.958702913594936 bayes_pls_golite062009
passive transmembrane transporter activity 0.958702913594936 bayes_pls_golite062009
ion channel activity 0.935000804348868 bayes_pls_golite062009
substrate-specific channel activity 0.934955860431071 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.880236579821909 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
activin receptor activity 0.811117252475389 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
nucleic acid binding 0.794058505655489 bayes_pls_golite062009
transcription regulator activity 0.775404673285876 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
DNA binding 0.714163549867672 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
Janus kinase activity 0.580310109637219 bayes_pls_golite062009
transcription factor activity 0.563262875317016 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.546647574638943 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.53226085423174 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
sequence-specific DNA binding 0.487555922788887 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
transcription activator activity 0.481994471237116 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding 0.372842462336059 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
photoreceptor activity 0.207734350319491 bayes_pls_golite062009
cell adhesion molecule binding 0.150740450460731 bayes_pls_golite062009
activin receptor activity, type I 0.117759584117941 bayes_pls_golite062009
JUN kinase kinase kinase activity 0.0613131034808199 bayes_pls_golite062009
cation binding 0.046173055856133 bayes_pls_golite062009
metal ion binding 0.046173055856133 bayes_pls_golite062009
ion binding 0.0389662058697694 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle