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View Structure Prediction Details

Protein: PHO85
Organism: Saccharomyces cerevisiae
Length: 305 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO85.

Description E-value Query
Range		 Subject
Range
CDC21_ORYSA, CC2... - Cell division control protein 2 homolog 1 (EC 2.7.11.22) - Oryza sativa (Rice), (P29618) Cell divisi...
CDKA1_ORYSJ - Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica GN=CDKA-1 PE=1 SV=1
 0.0 [4..300] [1..290]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..300] [1..290]
CDC2_OXYRB - Cell division control protein 2 homolog OS=Oxybasis rubra GN=CDC2 PE=2 SV=1
 0.0 [4..299] [1..289]
CDC2A_ANTMA - Cell division control protein 2 homolog A OS=Antirrhinum majus GN=CDC2A PE=2 SV=2
 0.0 [4..299] [1..289]
gi|4096103 - gi|4096103|gb|AAD10483.1| p34cdc2 [Triticum aestivum]
 0.0 [4..299] [1..289]
gi|9885803 - gi|9885803|gb|AAG01534.1|AF289467_1 cyclin-dependent kinase A:4 [Nicotiana tabacum]
 0.0 [4..299] [1..289]
gi|3123616 - gi|3123616|emb|CAA76701.1| cyclin-dependent protein kinase p34cdc2 [Solanum lycopersicum]
 0.0 [4..299] [1..289]
CDC2_MAIZE - Cell division control protein 2 homolog OS=Zea mays GN=CDC2 PE=2 SV=1
 0.0 [4..300] [1..290]

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Predicted Domain #1
Region A:
Residues: [1-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSQFKQL EKLGNGTYAT VYKGLNKTTG VYVALKEVKL DSEEGTPSTA IREISLMKEL  60
   61 KHENIVRLYD VIHTENKLTL VFEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1080.218487
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine receptor activator activity 5.9159846946654 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
MAP kinase 2 activity 3.27009208121248 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.79505438761262 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
histone kinase activity (H3-S10 specific) 2.30449166929476 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.66976264488423 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.60259443694567 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription elongation regulator activity 1.16995153203536 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.03605423743048 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
fibroblast growth factor binding 0.870666814073948 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
beta-catenin binding 0.693246095477001 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.149958560815481 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.149958560815481 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.14842991990838 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.0794053647730006 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-169] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNDLKKYMD SRTVGNTPRG LELNLVKYFQ WQLLQGLAFC HENKILHRDL KPQNLLINKR  60
   61 GQLKLGDFGL ARAFGIPVNT FSSEV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [299-305] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYYHHAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1080.218487
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [170-220] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTLWYRAPDV LMGSRTYSTS IDIWSCGCIL AEMITGKPLF PGTNDEEQLK L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1080.218487
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [221-298] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFDIMGTPNE SLWPSVTKLP KYNPNIQQRP PRDLRQVLQP HTKEPLDGNL MDFLHGLLQL  60
   61 NPDMRLSAKQ ALHHPWFA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1080.218487
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle