| Protein: | MRK1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 501 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRK1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [26..491] | [8..471] |
|
|
0.0 | [26..491] | [8..470] |
|
|
0.0 | [26..490] | [8..467] |
|
|
0.0 | [102..492] | [17..405] |
|
Region A: Residues: [1-90] |
1 11 21 31 41 51
| | | | | |
1 MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV QVHHTVPNFN 60
61 NSSEYINDIE NLIISKLIDG GKEGIAVDHI
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.432 | a.39.1 | EF-hand |
| View | Download | 0.550 | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.631 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.446 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.702 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.702 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.631 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.550 | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.446 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.434 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.425 | a.24.15 | FAD-dependent thiol oxidase |
| View | Download | 0.403 | d.111.1 | PR-1-like |
| View | Download | 0.382 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.375 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.373 | a.69.3 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain |
| View | Download | 0.366 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.366 | a.46.1 | Methionine synthase domain |
| View | Download | 0.361 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.359 | a.29.2 | Bromodomain |
| View | Download | 0.356 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.355 | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.351 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.344 | a.150.1 | Anti-sigma factor AsiA |
| View | Download | 0.344 | d.56.1 | GroEL-intermediate domain like |
| View | Download | 0.343 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.341 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.304 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.298 | d.49.1 | Signal recognition particle alu RNA binding heterodimer, SRP9/14 |
| View | Download | 0.294 | a.39.1 | EF-hand |
| View | Download | 0.286 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.285 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.283 | a.1.1 | Globin-like |
| View | Download | 0.276 | a.1.1 | Globin-like |
| View | Download | 0.264 | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.259 | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.259 | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.248 | c.47.1 | Thioredoxin-like |
| View | Download | 0.242 | d.52.3 | Prokaryotic type KH domain (KH-domain type II) |
| View | Download | 0.236 | d.141.1 | Ribosomal protein L6 |
| View | Download | 0.232 | c.23.12 | Formate/glycerate dehydrogenase catalytic domain-like |
| View | Download | 0.228 | d.141.1 | Ribosomal protein L6 |
| View | Download | 0.227 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.213 | a.60.2 | RuvA domain 2-like |
| View | Download | 0.212 | d.80.1 | Tautomerase/MIF |
| View | Download | 0.206 | a.2.3 | Chaperone J-domain |
|
Region A: Residues: [91-241] |
1 11 21 31 41 51
| | | | | |
1 EHANISDSKT DGKVANKHEN ISSKLSKEKV EKMINFDYRY IKTKERTIHK RVYKHDRKTD 60
61 VDRKNHGGTI DISYPTTEVV GHGSFGVVVT TVIIETNQKV AIKKVLQDRR YKNRELETMK 120
121 MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD Y
|
| Detection Method: | |
| Confidence: | 1073.9897 |
| Match: | 1i09A_ |
| Description: | Glycogen synthase kinase-3 beta (Gsk3b) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| general RNA polymerase II transcription factor activity | 5.68265749805481 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| structural molecule activity | 3.82327979736517 | bayes_pls_golite062009 |
| MAP kinase 2 activity | 3.27009208121248 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.41610417530517 | bayes_pls_golite062009 |
| histone kinase activity (H3-S10 specific) | 2.30449166929476 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 2.19834311533772 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 1.93176092222748 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 1.90354666768303 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| molecular transducer activity | 1.79921740914853 | bayes_pls_golite062009 |
| signal transducer activity | 1.79921740914853 | bayes_pls_golite062009 |
| telethonin binding | 1.75733591474207 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 1.71452519680794 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 1.68012041942855 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 1.45392497707807 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 1.4045088027491 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 1.4045088027491 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 1.3898059094397 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.38496328649031 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| actin binding | 1.33479685165255 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.27291233344322 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.27184436658773 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 1.2662335835562 | bayes_pls_golite062009 |
| insulin receptor activity | 1.22442673174261 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.16995153203536 | bayes_pls_golite062009 |
| transcription repressor activity | 1.14496167267281 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.0383359654359 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 1.03605423743048 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| PTB domain binding | 0.9900774724568 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.913893847407112 | bayes_pls_golite062009 |
| alpha-actinin binding | 0.877087652539674 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| receptor activity | 0.775180603313375 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.728917900114111 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 0.705634826374884 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 0.705634826374884 | bayes_pls_golite062009 |
| hormone receptor binding | 0.705067960165986 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.666159109886349 | bayes_pls_golite062009 |
| activin binding | 0.664317770352101 | bayes_pls_golite062009 |
| insulin binding | 0.614254468447749 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| transporter activity | 0.595111702412257 | bayes_pls_golite062009 |
| activin receptor activity | 0.558143200755109 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activating kinase activity | 0.529121666062889 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.505233004492768 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.470448662251808 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| kinase binding | 0.443916188551908 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.41384976209545 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase regulator activity | 0.406297251827056 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| potassium channel regulator activity | 0.359831178301818 | bayes_pls_golite062009 |
| axon guidance receptor activity | 0.330635248803668 | bayes_pls_golite062009 |
| ephrin receptor activity | 0.320275111520979 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| protein kinase binding | 0.285611963740145 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| RNA binding | 0.245748631571068 | bayes_pls_golite062009 |
| cation channel activity | 0.245400615103891 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.240883589532225 | bayes_pls_golite062009 |
| actin filament binding | 0.2403700250846 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| growth factor binding | 0.153144089598532 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.114318824149111 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.0922946791401962 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [242-501] |
1 11 21 31 41 51
| | | | | |
1 MPQSLYQRLR HFVNLKMQMP RVEIKFYAYQ LFKALNYLHN VPRICHRDIK PQNLLVDPTT 60
61 FSFKICDFGS AKCLKPDQPN VSYICSRYYR APELMFGATN YSNQVDVWSS ACVIAELLLG 120
121 KPLFSGESGI DQLVEIIKIM GIPTKDEISG MNPNYEDHVF PNIKPITLAE IFKAEDPDTL 180
181 DLLTKTLKYH PCERLVPLQC LLSSYFDETK RCDTDTYVKA QNLRIFDFDV ETELGHVPLV 240
241 ERPAIEERLK HFVSAPSSSL
|
| Detection Method: | |
| Confidence: | 1073.9897 |
| Match: | 1i09A_ |
| Description: | Glycogen synthase kinase-3 beta (Gsk3b) |
| Matching Structure (courtesy of the PDB): |
|
