| Protein: | gi|60656373, gi|... |
| Organism: | synthetic construct |
| Length: | 459 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|60656373, gi|....
| Description | E-value | Query Range |
Subject Range |
|
|
4.0E-61 | [1..459] | [155..612] |
|
|
6.0E-58 | [1..459] | [1..459] |
|
|
1.0E-57 | [1..459] | [1..459] |
|
|
2.0E-57 | [1..459] | [1..459] |
|
|
7.0E-57 | [1..459] | [1..458] |
|
|
3.0E-55 | [1..459] | [1..458] |
|
Region A: Residues: [1-118] |
1 11 21 31 41 51
| | | | | |
1 MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW 60
61 LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGS
|
| Detection Method: |  |
| Confidence: | 26.69897 |
| Match: | 1n1aA |
| Description: | FKBP52, N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ryanodine-sensitive calcium-release channel activity | 10.9968443145942 | bayes_pls_golite062009 |
| intracellular ligand-gated calcium channel activity | 10.9968443145942 | bayes_pls_golite062009 |
| macrolide binding | 7.31599503004442 | bayes_pls_golite062009 |
| FK506 binding | 7.22442625476031 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 6.74926751944787 | bayes_pls_golite062009 |
| calcium channel activity | 6.4374377859142 | bayes_pls_golite062009 |
| cation channel activity | 6.06732269872248 | bayes_pls_golite062009 |
| ion channel activity | 5.45007096522107 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 5.32426176964634 | bayes_pls_golite062009 |
| channel activity | 5.32426176964634 | bayes_pls_golite062009 |
| substrate-specific channel activity | 5.28960420749143 | bayes_pls_golite062009 |
| gated channel activity | 5.28074654906904 | bayes_pls_golite062009 |
| peptidyl-prolyl cis-trans isomerase activity | 4.0615867467963 | bayes_pls_golite062009 |
| cis-trans isomerase activity | 3.99265212272703 | bayes_pls_golite062009 |
| ligand-gated channel activity | 3.34717828007833 | bayes_pls_golite062009 |
| ligand-gated ion channel activity | 3.34717828007833 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.6566793500337 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.61794461605199 | bayes_pls_golite062009 |
| calcium-release channel activity | 2.58969194870156 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.47257819150887 | bayes_pls_golite062009 |
| isomerase activity | 2.31710030777753 | bayes_pls_golite062009 |
| transcription regulator activity | 1.85589011277711 | bayes_pls_golite062009 |
| receptor activity | 1.78361575899771 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.7459556028988 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.68688812199737 | bayes_pls_golite062009 |
| kinase activity | 1.67904764195462 | bayes_pls_golite062009 |
| binding | 1.63170667962375 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.57898291235576 | bayes_pls_golite062009 |
| signal transducer activity | 1.53711974553033 | bayes_pls_golite062009 |
| molecular transducer activity | 1.53711974553033 | bayes_pls_golite062009 |
| protein kinase activity | 1.45320632553313 | bayes_pls_golite062009 |
| drug binding | 1.39643621593407 | bayes_pls_golite062009 |
| transferase activity | 1.34122735969662 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 1.32709321745178 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 1.32470025150272 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 1.32470025150272 | bayes_pls_golite062009 |
| transporter activity | 1.25197125648774 | bayes_pls_golite062009 |
| protein binding | 1.08765413491791 | bayes_pls_golite062009 |
| SMAD binding | 1.04905381164355 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.03909235910355 | bayes_pls_golite062009 |
| catalytic activity | 0.885282592863018 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.789390402522536 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 0.763739321802433 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 0.763739321802433 | bayes_pls_golite062009 |
| intracellular ligand-gated ion channel activity | 0.727019445105701 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.671059013500415 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.525950701946406 | bayes_pls_golite062009 |
| unfolded protein binding | 0.27473817613726 | bayes_pls_golite062009 |
| activin binding | 0.262691232876501 | bayes_pls_golite062009 |
| histone binding | 0.221748741603068 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 0.21145105012677 | bayes_pls_golite062009 |
|
Region A: Residues: [119-316] |
1 11 21 31 41 51
| | | | | |
1 PPKIPPNATL VFEVELFEFK GEDLTEEEDG GIIRRIQTRG EGYAKPNEGA IVEVALEGYY 60
61 KDKLFDQREL RFEIGEGENL DLPYGLERAI QRMEKGEHSI VYLKPSYAFG SVGKEKFQIP 120
121 PNAELKYELH LKSFEKAKES WEMNSEEKLE QSTIVKERGT VYFKEGKYKQ ALLQYKKIVS 180
181 WLEYESSFSN EEAQKAQA
|
| Detection Method: | |
| Confidence: | 4.95 |
| Match: | 1kt0A |
| Description: | FKBP51, C-terminal domain; FKBP51, N-terminal domains |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ryanodine-sensitive calcium-release channel activity | 10.5818680850178 | bayes_pls_golite062009 |
| intracellular ligand-gated calcium channel activity | 10.5818680850178 | bayes_pls_golite062009 |
| macrolide binding | 6.76364038125885 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 6.73398709732238 | bayes_pls_golite062009 |
| FK506 binding | 6.68168417220699 | bayes_pls_golite062009 |
| procollagen-proline 4-dioxygenase activity | 6.33141891074556 | bayes_pls_golite062009 |
| procollagen-proline dioxygenase activity | 6.33141891074556 | bayes_pls_golite062009 |
| peptidyl-proline dioxygenase activity | 6.33141891074556 | bayes_pls_golite062009 |
| peptidyl-proline 4-dioxygenase activity | 6.33141891074556 | bayes_pls_golite062009 |
| calcium channel activity | 6.26093539961789 | bayes_pls_golite062009 |
| cation channel activity | 6.02454701753153 | bayes_pls_golite062009 |
| protein phosphatase 2A binding | 5.70177601384074 | bayes_pls_golite062009 |
| ion channel activity | 5.41446659728328 | bayes_pls_golite062009 |
| channel activity | 5.29566611694414 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 5.29566611694414 | bayes_pls_golite062009 |
| substrate-specific channel activity | 5.25915730995039 | bayes_pls_golite062009 |
| gated channel activity | 5.23693345098661 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 4.40754649831781 | bayes_pls_golite062009 |
| peptidyl-prolyl cis-trans isomerase activity | 3.47347683498372 | bayes_pls_golite062009 |
| cis-trans isomerase activity | 3.41272339669823 | bayes_pls_golite062009 |
| ligand-gated channel activity | 3.27653035675626 | bayes_pls_golite062009 |
| ligand-gated ion channel activity | 3.27653035675626 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.66103271426565 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.61980214265117 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.48031953795714 | bayes_pls_golite062009 |
| phosphatase activity | 2.44706583719107 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.38926130931194 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 2.32557041601016 | bayes_pls_golite062009 |
| calcium-release channel activity | 2.24272229394245 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 2.09150703279726 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.08144339124986 | bayes_pls_golite062009 |
| isomerase activity | 1.92777278447686 | bayes_pls_golite062009 |
| transcription regulator activity | 1.83171242300949 | bayes_pls_golite062009 |
| receptor activity | 1.78786100885722 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.75042985427656 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.6949579078176 | bayes_pls_golite062009 |
| kinase activity | 1.68748031932496 | bayes_pls_golite062009 |
| binding | 1.66926716799278 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.58792227723443 | bayes_pls_golite062009 |
| signal transducer activity | 1.54949624451448 | bayes_pls_golite062009 |
| molecular transducer activity | 1.54949624451448 | bayes_pls_golite062009 |
| phosphoprotein phosphatase activity | 1.48932763287956 | bayes_pls_golite062009 |
| protein kinase activity | 1.4606316161198 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.42907226857237 | bayes_pls_golite062009 |
| transferase activity | 1.35149948487544 | bayes_pls_golite062009 |
| DNA binding | 1.32823848889363 | bayes_pls_golite062009 |
| transporter activity | 1.26515051009051 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 1.25364237438323 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 1.24715902371406 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 1.24715902371406 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 1.1910515648311 | bayes_pls_golite062009 |
| protein binding | 1.13205057608753 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.05129296782391 | bayes_pls_golite062009 |
| nucleic acid binding | 1.03214696367403 | bayes_pls_golite062009 |
| drug binding | 1.02692887826597 | bayes_pls_golite062009 |
| heat shock protein binding | 0.974870566753586 | bayes_pls_golite062009 |
| SMAD binding | 0.923832336018678 | bayes_pls_golite062009 |
| transcription activator activity | 0.865375739926993 | bayes_pls_golite062009 |
| catalytic activity | 0.838457647933563 | bayes_pls_golite062009 |
| transcription repressor activity | 0.831782705534701 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.7991885026596 | bayes_pls_golite062009 |
| hormone receptor binding | 0.7429757196483 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.713457194766522 | bayes_pls_golite062009 |
| transcription factor activity | 0.679223944174373 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 0.679185625455585 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 0.679185625455585 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.676568185178303 | bayes_pls_golite062009 |
| protein serine/threonine phosphatase activity | 0.620169189588866 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.599036230630856 | bayes_pls_golite062009 |
| intracellular ligand-gated ion channel activity | 0.547008204307472 | bayes_pls_golite062009 |
| transferase activity, transferring hexosyl groups | 0.513111849696122 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.510792404154917 | bayes_pls_golite062009 |
| enzyme binding | 0.335436488591595 | bayes_pls_golite062009 |
| unfolded protein binding | 0.23321005341344 | bayes_pls_golite062009 |
| transcription factor binding | 0.202402797164729 | bayes_pls_golite062009 |
| hydrolase activity | 0.191714540920279 | bayes_pls_golite062009 |
| histone binding | 0.187349169865552 | bayes_pls_golite062009 |
| activin binding | 0.155745749643662 | bayes_pls_golite062009 |
| signal sequence binding | 0.144756387712192 | bayes_pls_golite062009 |
| superoxide-generating NADPH oxidase activity | 0.0442139417921878 | bayes_pls_golite062009 |
|
Region A: Residues: [317-459] |
1 11 21 31 41 51
| | | | | |
1 LRLASHLNLA MCHLKLQAFS AAIESCNKAL ELDSNNEKGL FRRGEAHLAV NDFELARADF 60
61 QKVLQLYPNN KAAKTQLAVC QQRIRRQLAR EKKLYANMFE RLAEEENKAK AEASSGDHPT 120
121 DTEMKEEQKS NTAGSQSQVE TEA
|
| Detection Method: | |
| Confidence: | 27.30103 |
| Match: | 1qz2A |
| Description: | Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| intracellular ligand-gated calcium channel activity | 10.9968443145942 | bayes_pls_golite062009 |
| ryanodine-sensitive calcium-release channel activity | 10.9968443145942 | bayes_pls_golite062009 |
| macrolide binding | 7.31599503004442 | bayes_pls_golite062009 |
| FK506 binding | 7.22442625476031 | bayes_pls_golite062009 |
| peptidyl-proline dioxygenase activity | 6.80616214194201 | bayes_pls_golite062009 |
| procollagen-proline dioxygenase activity | 6.80616214194201 | bayes_pls_golite062009 |
| peptidyl-proline 4-dioxygenase activity | 6.80616214194201 | bayes_pls_golite062009 |
| procollagen-proline 4-dioxygenase activity | 6.80616214194201 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 6.74926751944787 | bayes_pls_golite062009 |
| calcium channel activity | 6.4374377859142 | bayes_pls_golite062009 |
| cation channel activity | 6.06732269872248 | bayes_pls_golite062009 |
| protein phosphatase 2A binding | 6.03345119957353 | bayes_pls_golite062009 |
| ion channel activity | 5.45007096522107 | bayes_pls_golite062009 |
| channel activity | 5.32426176964634 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 5.32426176964634 | bayes_pls_golite062009 |
| substrate-specific channel activity | 5.28960420749143 | bayes_pls_golite062009 |
| gated channel activity | 5.28074654906904 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 4.77770372249654 | bayes_pls_golite062009 |
| peptidyl-prolyl cis-trans isomerase activity | 4.0615867467963 | bayes_pls_golite062009 |
| cis-trans isomerase activity | 3.99265212272703 | bayes_pls_golite062009 |
| ligand-gated ion channel activity | 3.34717828007833 | bayes_pls_golite062009 |
| ligand-gated channel activity | 3.34717828007833 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.6566793500337 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.61794461605199 | bayes_pls_golite062009 |
| calcium-release channel activity | 2.58969194870156 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.47257819150887 | bayes_pls_golite062009 |
| phosphatase activity | 2.4502869290841 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.38923256228405 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 2.35894350869919 | bayes_pls_golite062009 |
| isomerase activity | 2.31710030777753 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 2.12083180880718 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.07186557005331 | bayes_pls_golite062009 |
| transcription regulator activity | 1.85589011277711 | bayes_pls_golite062009 |
| receptor activity | 1.78361575899771 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.7459556028988 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.68688812199737 | bayes_pls_golite062009 |
| kinase activity | 1.67904764195462 | bayes_pls_golite062009 |
| binding | 1.63170667962375 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.57898291235576 | bayes_pls_golite062009 |
| molecular transducer activity | 1.53711974553033 | bayes_pls_golite062009 |
| signal transducer activity | 1.53711974553033 | bayes_pls_golite062009 |
| phosphoprotein phosphatase activity | 1.5101001424727 | bayes_pls_golite062009 |
| protein kinase activity | 1.45320632553313 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.4415534360016 | bayes_pls_golite062009 |
| drug binding | 1.39643621593407 | bayes_pls_golite062009 |
| heat shock protein binding | 1.35268080101836 | bayes_pls_golite062009 |
| transferase activity | 1.34122735969662 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 1.32709321745178 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 1.32470025150272 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 1.32470025150272 | bayes_pls_golite062009 |
| DNA binding | 1.31957293306432 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 1.26630556032955 | bayes_pls_golite062009 |
| transporter activity | 1.25197125648774 | bayes_pls_golite062009 |
| protein binding | 1.08765413491791 | bayes_pls_golite062009 |
| SMAD binding | 1.04905381164355 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.03909235910355 | bayes_pls_golite062009 |
| nucleic acid binding | 1.01193875360949 | bayes_pls_golite062009 |
| catalytic activity | 0.885282592863018 | bayes_pls_golite062009 |
| transcription activator activity | 0.873307397500777 | bayes_pls_golite062009 |
| transcription repressor activity | 0.841959344808827 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.789390402522536 | bayes_pls_golite062009 |
| hormone receptor binding | 0.780875583795532 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.777060600234881 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 0.763739321802433 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 0.763739321802433 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.761034574704448 | bayes_pls_golite062009 |
| intracellular ligand-gated ion channel activity | 0.727019445105701 | bayes_pls_golite062009 |
| protein serine/threonine phosphatase activity | 0.683689287992235 | bayes_pls_golite062009 |
| transcription factor activity | 0.672036990681626 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.671059013500415 | bayes_pls_golite062009 |
| transferase activity, transferring hexosyl groups | 0.625352830428438 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.525950701946406 | bayes_pls_golite062009 |
| signal sequence binding | 0.49295886046194 | bayes_pls_golite062009 |
| enzyme binding | 0.44905827271946 | bayes_pls_golite062009 |
| superoxide-generating NADPH oxidase activity | 0.37588912752498 | bayes_pls_golite062009 |
| unfolded protein binding | 0.27473817613726 | bayes_pls_golite062009 |
| transcription factor binding | 0.273314664611729 | bayes_pls_golite062009 |
| activin binding | 0.262691232876501 | bayes_pls_golite062009 |
| histone binding | 0.221748741603068 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 0.21145105012677 | bayes_pls_golite062009 |
| hydrolase activity | 0.172906111259113 | bayes_pls_golite062009 |
| peroxisome targeting sequence binding | 0.0468412220974996 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor | 0.0437303095920707 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.0131115480611301 | bayes_pls_golite062009 |
