YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|55670684, gi\|...
Organism:	Homo sapiens
Length:	177 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55670684, gi|....

Description	E-value	Query Range	Subject Range
gi\|103720 - gi\|103720\|pir\|\|D38625 GTP-binding protein o-rab1 - electric ray (Discopyge ommata)	202.0	[0..3]	[176..4]
gi\|220679635, gi... - gi\|50345016\|ref\|NP_001002178.1\| hypothetical protein LOC431725 [Danio rerio], gi\|49117792\|gb\|AAH7271...	202.0	[0..2]	[176..3]
gi\|303734, gi\|738942 - gi\|738942\|prf\|\|2001457K GTP-binding protein, gi\|303734\|dbj\|BAA02118.1\| GTP-binding protein [Pisum sa... gi\|1098293, gi\|4... - pir\|\|S41430 GTP-binding protein, ras-like (clone vfa-ypt1) - fava bean, gi\|452359\|emb\|CAA82707.1\| g...	201.0	[0..3]	[176..4]
ARA5_ARATH - Ras-related protein ARA-5 - Arabidopsis thaliana (Mouse-ear cress)	201.0	[0..3]	[176..59]
gi\|1616614 - gi\|1616614\|emb\|CAA69701.1\| small GTP-binding protein [Nicotiana plumbaginifolia]	201.0	[0..3]	[176..4]
gi\|114638536 - gi\|114638536\|ref\|XP_001150399.1\| PREDICTED: similar to RAB1B, member RAS oncogene family [Pan troglo...	200.0	[0..2]	[176..57]
gi\|50738954 - gi\|50738954\|ref\|XP_419342.1\| PREDICTED: similar to ras-related protein [Gallus gallus]	200.0	[0..4]	[176..196]
gi\|421942, gi\|311907 - pir\|\|S34253 GTP-binding protein, ras-related - common tobacco, gi\|311907\|emb\|CAA51011.1\| ras-related...	200.0	[0..3]	[176..4]

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Predicted Domain #1

Region A:
Residues: [1-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE VDGHFVTMQI  60
   61 WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV 120
  121 ILGNKIDISE RQVSTEEAQA WCRDNGDYPY FETSAKDATN VAAAFEEAVR RVLATED

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Detection Method:	PSI-BLAST
Confidence:	51.0
Match:	1wmsA
Description:	High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.89122312915795	bayes_pls_golite062009
pyrophosphatase activity	2.81593838944939	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.79724985811732	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.79347973548337	bayes_pls_golite062009
hydrolase activity	2.65461298232951	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity	2.44176688200537	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.26365379756656	bayes_pls_golite062009
motor activity	2.1532118704195	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
microtubule motor activity	2.10113120386841	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
GTPase activity	1.6309422514633	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
helicase activity	1.16085745407703	bayes_pls_golite062009
actin filament binding	1.15038324907212	bayes_pls_golite062009
kinase activity	1.11120928120082	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
cation channel activity	0.997064416395892	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.908046791062776	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
transcription activator activity	0.739301862805678	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
microfilament motor activity	0.723407201613229	bayes_pls_golite062009
voltage-gated cation channel activity	0.688632087597536	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
transmembrane receptor activity	0.661834961742057	bayes_pls_golite062009
steroid hormone receptor binding	0.647625526012423	bayes_pls_golite062009
calcium channel activity	0.636216614902039	bayes_pls_golite062009
receptor activity	0.633514002718998	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.621822998821133	bayes_pls_golite062009
cell surface binding	0.618263399939881	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
ATP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
cytoskeletal protein binding	0.568484017802328	bayes_pls_golite062009
actin binding	0.563996324417607	bayes_pls_golite062009
voltage-gated channel activity	0.562664200036023	bayes_pls_golite062009
voltage-gated ion channel activity	0.559798751382976	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.421921195209539	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
hormone receptor binding	0.351501100511918	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
potassium channel activity	0.329290830676079	bayes_pls_golite062009
tubulin binding	0.326239364039846	bayes_pls_golite062009
gated channel activity	0.299411774392227	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
structure-specific DNA binding	0.249173645231486	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.248918847596573	bayes_pls_golite062009
nuclear hormone receptor binding	0.246160342138071	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
microtubule binding	0.225323885896927	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.22150712609541	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
ion channel activity	0.154779598791225	bayes_pls_golite062009
channel activity	0.134817721656507	bayes_pls_golite062009
passive transmembrane transporter activity	0.134817721656507	bayes_pls_golite062009
substrate-specific channel activity	0.126911677161968	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.11051537119918	bayes_pls_golite062009
voltage-gated calcium channel activity	0.0789800146503108	bayes_pls_golite062009
double-stranded DNA binding	0.0781650226500197	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.0122470146764899	bayes_pls_golite062009
DNA polymerase activity	4.95561462330096E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: