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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Mag1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AI1
  • mitochondrion
  • cellular respiration
  • mRNA processing
  • homing of group II introns
  • nucleic acid binding
  • endonuclease activity
  • FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • HHO1
  • nucleus
  • nuclear nucleosome
  • regulation of transcription, DNA-dependent
  • negative regulation of DNA recombination
  • DNA binding
  • IMD2
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD4
  • cytoplasm
  • biological_process
  • IMP dehydrogenase activity
  • MAG1
  • nucleus
  • DNA dealkylation involved in DNA repair
  • alkylbase DNA N-glycosylase activity
  • MPH1
  • nucleus
  • DNA repair
  • RNA helicase activity
  • 3'-5' DNA helicase activity
  • MSH2
  • nucleus
  • nuclear chromosome
  • removal of nonhomologous ends
  • DNA recombination
  • meiotic gene conversion
  • meiotic mismatch repair
  • mismatch repair
  • chromatin silencing at silent mating-type cassette
  • mitotic recombination
  • ATPase activity
  • ATP binding
  • double-strand/single-strand DNA junction binding
  • DNA insertion or deletion binding
  • loop DNA binding
  • Y-form DNA binding
  • four-way junction DNA binding
  • guanine/thymine mispair binding
  • single base insertion or deletion binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • RET1
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • RPC82
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF4632
  • eukaryotic translation initiation factor 4F complex
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 4F complex 3.1744E-5 15 4 2 6292
    DNA-directed RNA polymerase III complex 7.0676E-4 15 17 2 6292
    DNA-directed RNA polymerase complex 2.3703E-3 15 31 2 6292
    RNA polymerase complex 2.3703E-3 15 31 2 6292
    nuclear DNA-directed RNA polymerase complex 2.3703E-3 15 31 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    GTP biosynthetic process 5.3053E-6 15 2 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0815E-4 15 1566 11 6292
    GTP metabolic process 1.1065E-4 15 7 2 6292
    translational initiation 1.1904E-4 15 42 3 6292
    primary metabolic process 1.614E-4 15 2896 14 6292
    cellular metabolic process 2.9771E-4 15 3033 14 6292
    cellular nitrogen compound metabolic process 3.5742E-4 15 1770 11 6292
    nitrogen compound metabolic process 4.0047E-4 15 1791 11 6292
    metabolic process 5.0484E-4 15 3157 14 6292
    cellular macromolecule metabolic process 6.971E-4 15 2285 12 6292
    gene expression 8.9699E-4 15 1283 9 6292
    macromolecule metabolic process 9.3161E-4 15 2349 12 6292
    purine ribonucleoside triphosphate biosynthetic process 1.1922E-3 15 22 2 6292
    purine nucleoside triphosphate biosynthetic process 1.1922E-3 15 22 2 6292
    ribonucleoside triphosphate biosynthetic process 1.4205E-3 15 24 2 6292
    purine ribonucleoside triphosphate metabolic process 1.7991E-3 15 27 2 6292
    purine nucleoside triphosphate metabolic process 1.7991E-3 15 27 2 6292
    nucleoside triphosphate biosynthetic process 1.7991E-3 15 27 2 6292
    nucleic acid metabolic process 1.8909E-3 15 1415 9 6292
    ribonucleoside triphosphate metabolic process 2.0753E-3 15 29 2 6292
    DNA recombination 2.2486E-3 15 114 3 6292
    meiotic gene conversion 2.384E-3 15 1 1 6292
    homing of group II introns 2.384E-3 15 1 1 6292
    nucleoside triphosphate metabolic process 2.8479E-3 15 34 2 6292
    transcription from RNA polymerase III promoter 3.5492E-3 15 38 2 6292
    RNA metabolic process 3.7928E-3 15 954 7 6292
    cellular biosynthetic process 4.0349E-3 15 1567 9 6292
    purine ribonucleotide biosynthetic process 4.323E-3 15 42 2 6292
    biosynthetic process 4.7409E-3 15 1602 9 6292
    ribonucleotide biosynthetic process 4.9503E-3 15 45 2 6292
    purine nucleotide biosynthetic process 5.848E-3 15 49 2 6292
    purine ribonucleotide metabolic process 6.5668E-3 15 52 2 6292
    ribonucleotide metabolic process 7.324E-3 15 55 2 6292
    purine nucleotide metabolic process 8.119E-3 15 58 2 6292
    DNA metabolic process 9.3124E-3 15 585 5 6292
    DNA modification 9.5041E-3 15 4 1 6292
    DNA dealkylation involved in DNA repair 9.5041E-3 15 4 1 6292
    DNA dealkylation 9.5041E-3 15 4 1 6292
    DNA repair 9.707E-3 15 192 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    IMP dehydrogenase activity 1.0965E-8 15 3 3 6292
    translation initiation factor activity 3.0988E-5 15 27 3 6292
    nucleic acid binding 4.9401E-5 15 666 8 6292
    translation factor activity, nucleic acid binding 1.3693E-4 15 44 3 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6.1686E-4 15 73 3 6292
    oxidoreductase activity, acting on CH-OH group of donors 8.3654E-4 15 81 3 6292
    alkylbase DNA N-glycosylase activity 2.384E-3 15 1 1 6292
    RNA polymerase activity 2.8479E-3 15 34 2 6292
    DNA-directed RNA polymerase activity 2.8479E-3 15 34 2 6292
    3'-5' DNA helicase activity 4.7627E-3 15 2 1 6292
    single base insertion or deletion binding 4.7627E-3 15 2 1 6292
    binding 5.0296E-3 15 1294 8 6292
    double-strand/single-strand DNA junction binding 7.136E-3 15 3 1 6292
    loop DNA binding 7.136E-3 15 3 1 6292
    Y-form DNA binding 7.136E-3 15 3 1 6292
    guanine/thymine mispair binding 7.136E-3 15 3 1 6292
    four-way junction DNA binding 9.5041E-3 15 4 1 6292

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