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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Tpk3. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE5,7
  • cytoplasm
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • purine base metabolic process
  • phosphoribosylamine-glycine ligase activity
  • phosphoribosylformylglycinamidine cyclo-ligase activity
  • BCY1
  • nucleus
  • cytoplasm
  • response to heat
  • signal transduction
  • pseudohyphal growth
  • response to stress
  • cAMP-dependent protein kinase inhibitor activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • JJJ1
  • cytoplasm
  • mitochondrion
  • cytosol
  • ribosomal large subunit biogenesis
  • regulation of cell size
  • endocytosis
  • Hsp70/Hsc70 protein regulator activity
  • ATPase activator activity
  • PFK1
  • 6-phosphofructokinase complex
  • cytoplasm
  • mitochondrion
  • glycolysis
  • 6-phosphofructokinase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • TPK1
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • pseudohyphal growth
  • Ras protein signal transduction
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • TPK3
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • positive regulation of apoptosis
  • pseudohyphal growth
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • YHR214W-A
    YPT7
  • mitochondrial outer membrane
  • vacuole
  • vacuole inheritance
  • vesicle-mediated transport
  • telomere maintenance
  • vacuole fusion, non-autophagic
  • endocytosis
  • Golgi to vacuole transport
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cAMP-dependent protein kinase complex 9.9937E-6 12 3 2 6292
    6-phosphofructokinase complex 3.811E-3 12 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of cell size 4.0727E-5 12 111 4 6292
    regulation of anatomical structure size 4.5238E-5 12 114 4 6292
    regulation of cellular component size 4.5238E-5 12 114 4 6292
    pseudohyphal growth 2.4776E-4 12 68 3 6292
    cell growth 4.4694E-4 12 83 3 6292
    filamentous growth of a population of unicellular organisms 5.6716E-4 12 90 3 6292
    growth of unicellular organism as a thread of attached cells 5.6716E-4 12 90 3 6292
    filamentous growth 9.1542E-4 12 106 3 6292
    growth 2.2639E-3 12 145 3 6292
    regulation of biological quality 2.3795E-3 12 551 5 6292
    positive regulation of programmed cell death 5.7116E-3 12 3 1 6292
    positive regulation of cell death 5.7116E-3 12 3 1 6292
    positive regulation of apoptosis 5.7116E-3 12 3 1 6292
    regulation of programmed cell death 7.6087E-3 12 4 1 6292
    regulation of cell death 7.6087E-3 12 4 1 6292
    regulation of apoptosis 7.6087E-3 12 4 1 6292
    cellular carbohydrate catabolic process 7.9142E-3 12 72 2 6292
    carbohydrate catabolic process 8.565E-3 12 75 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclic nucleotide-dependent protein kinase activity 9.9937E-6 12 3 2 6292
    cAMP-dependent protein kinase activity 9.9937E-6 12 3 2 6292
    glycogen phosphorylase activity 1.9072E-3 12 1 1 6292
    cAMP-dependent protein kinase inhibitor activity 1.9072E-3 12 1 1 6292
    phosphoribosylformylglycinamidine cyclo-ligase activity 1.9072E-3 12 1 1 6292
    phosphoribosylamine-glycine ligase activity 1.9072E-3 12 1 1 6292
    phosphorylase activity 1.9072E-3 12 1 1 6292
    Hsp70/Hsc70 protein regulator activity 3.811E-3 12 2 1 6292
    6-phosphofructokinase activity 3.811E-3 12 2 1 6292
    phosphotransferase activity, alcohol group as acceptor 5.4731E-3 12 198 3 6292
    cyclo-ligase activity 5.7116E-3 12 3 1 6292
    kinase activity 7.5284E-3 12 222 3 6292
    protein serine/threonine kinase inhibitor activity 7.6087E-3 12 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle