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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Hrt1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • GUF1
  • mitochondrion
  • biological_process
  • GTPase activity
  • HRT1
  • nucleus
  • nuclear ubiquitin ligase complex
  • cytoplasm
  • SCF ubiquitin ligase complex
  • Cul3-RING ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • RIX7
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ATPase activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RTT101
  • nucleus
  • cytoplasm
  • regulation of mitosis
  • negative regulation of transposition, DNA-mediated
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • protein binding
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF ubiquitin ligase complex 7.7367E-5 8 11 2 6292
    cullin-RING ubiquitin ligase complex 1.2776E-4 8 14 2 6292
    ubiquitin ligase complex 1.2446E-3 8 43 2 6292
    Cul3-RING ubiquitin ligase complex 5.0773E-3 8 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 2.3558E-5 8 156 4 6292
    ubiquitin-dependent protein catabolic process 2.3558E-5 8 156 4 6292
    proteolysis involved in cellular protein catabolic process 2.5402E-5 8 159 4 6292
    modification-dependent macromolecule catabolic process 2.8711E-5 8 164 4 6292
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2.9615E-5 8 7 2 6292
    cellular protein catabolic process 3.3864E-5 8 171 4 6292
    proteolysis 4.9198E-5 8 188 4 6292
    protein catabolic process 5.0235E-5 8 189 4 6292
    cellular catabolic process 5.7807E-5 8 415 5 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 7.7367E-5 8 11 2 6292
    catabolic process 1.3679E-4 8 496 5 6292
    cellular macromolecule catabolic process 1.8833E-4 8 265 4 6292
    macromolecule catabolic process 2.8164E-4 8 294 4 6292
    G2/M transition of mitotic cell cycle 5.646E-4 8 29 2 6292
    G1/S transition of mitotic cell cycle 1.6809E-3 8 50 2 6292
    protein ubiquitination 2.8269E-3 8 65 2 6292
    mitotic cell cycle 3.1661E-3 8 255 3 6292
    proteasomal protein catabolic process 3.1803E-3 8 69 2 6292
    proteasomal ubiquitin-dependent protein catabolic process 3.1803E-3 8 69 2 6292
    protein modification by small protein conjugation 4.9014E-3 8 86 2 6292
    interphase of mitotic cell cycle 6.2001E-3 8 97 2 6292
    interphase 6.2001E-3 8 97 2 6292
    isocitrate metabolic process 6.3431E-3 8 5 1 6292
    protein modification by small protein conjugation or removal 8.4845E-3 8 114 2 6292
    cell cycle phase 9.4607E-3 8 376 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 3.8233E-5 8 57 3 6292
    small conjugating protein ligase activity 4.927E-5 8 62 3 6292
    acid-amino acid ligase activity 7.4057E-5 8 71 3 6292
    ligase activity, forming carbon-nitrogen bonds 1.713E-4 8 94 3 6292
    ligase activity 6.8116E-4 8 150 3 6292
    isocitrate dehydrogenase (NAD+) activity 2.5415E-3 8 2 1 6292
    isocitrate dehydrogenase activity 6.3431E-3 8 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle