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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APN2
  • nucleus
  • base-excision repair
  • DNA-(apurinic or apyrimidinic site) lyase activity
  • double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
  • phosphoric diester hydrolase activity
  • BFR1
  • polysome
  • ribonucleoprotein complex
  • nuclear membrane-endoplasmic reticulum network
  • mRNA metabolic process
  • regulation of mitosis
  • meiosis
  • RNA binding
  • BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • BUR2
  • nucleus
  • transcription
  • mitotic sister chromatid segregation
  • response to DNA damage stimulus
  • cyclin-dependent protein kinase regulator activity
  • LOC1
  • nucleus
  • intracellular mRNA localization
  • ribosomal large subunit biogenesis
  • mRNA binding
  • NHP6A
  • nuclear chromatin
  • chromatin remodeling
  • chromatin organization
  • positive regulation of transcription from RNA polymerase II promoter
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase II promoter
  • chromatin binding
  • PRK1
  • actin cortical patch
  • cytokinesis
  • actin filament organization
  • regulation of endocytosis
  • protein amino acid phosphorylation
  • actin cortical patch assembly
  • protein serine/threonine kinase activity
  • RIM1
  • mitochondrion
  • mitochondrial nucleoid
  • mitochondrial genome maintenance
  • single-stranded DNA binding
  • SGV1
  • nucleus
  • transcription
  • protein amino acid phosphorylation
  • cyclin-dependent protein kinase activity
  • SPB1
  • nucleus
  • nucleolus
  • rRNA methylation
  • processing of 27S pre-rRNA
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
  • TMA64
  • ribosome
  • biological_process
  • RNA binding
  • TSR1
  • cytoplasm
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribonucleoprotein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    intracellular non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    nucleolus 6.5368E-3 12 211 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.1264E-3 12 346 4 6292
    ribonucleoprotein complex biogenesis 4.1497E-3 12 374 4 6292
    rRNA methylation 5.7116E-3 12 3 1 6292
    regulation of endocytosis 5.7116E-3 12 3 1 6292
    ribosomal large subunit biogenesis 6.4883E-3 12 65 2 6292
    cellular component biogenesis 6.5683E-3 12 694 5 6292
    nucleic acid metabolic process 7.7238E-3 12 1415 7 6292
    regulation of cellular component organization 8.565E-3 12 75 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-stranded DNA specific 3'-5' exodeoxyribonuclease activity 3.811E-3 12 2 1 6292
    5S rRNA binding 3.811E-3 12 2 1 6292
    RNA binding 3.8749E-3 12 367 4 6292
    binding 4.5673E-3 12 1294 7 6292
    nucleic acid binding 5.4944E-3 12 666 5 6292
    rRNA (uridine) methyltransferase activity 5.7116E-3 12 3 1 6292
    rRNA (guanine) methyltransferase activity 5.7116E-3 12 3 1 6292
    rRNA (uridine-2'-O-)-methyltransferase activity 5.7116E-3 12 3 1 6292
    double-stranded DNA specific exodeoxyribonuclease activity 7.6087E-3 12 4 1 6292
    O-methyltransferase activity 7.6087E-3 12 4 1 6292
    rRNA primary transcript binding 9.5026E-3 12 5 1 6292
    DNA-(apurinic or apyrimidinic site) lyase activity 9.5026E-3 12 5 1 6292
    rRNA methyltransferase activity 9.5026E-3 12 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle