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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 12 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
APC1
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    APC2
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    APC4
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    APC5
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • chromatin assembly or disassembly
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    CDC16
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    CDC23
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    CDC26
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    CDC27
  • anaphase-promoting complex
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
    		•
  • ubiquitin-protein ligase activity
  • protein binding
    		•
    DOC1
  • anaphase-promoting complex
  • mitochondrion
    		•
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
    		•
  • enzyme regulator activity
    		•
    FMP52
  • mitochondrion
  • endoplasmic reticulum
  • mitochondrial outer membrane
    		•
  • biological_process
    		•
  • molecular_function
    		•
    MND2
  • nucleus
  • anaphase-promoting complex
    		•
  • regulation of mitotic metaphase/anaphase transition
  • reciprocal meiotic recombination
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination
    		•
  • molecular_function
    		•
    SSP2
  • ascospore wall
    		•
  • ascospore formation
  • ascospore wall assembly
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    anaphase-promoting complex 2.2854E-25 12 19 10 6292
    nuclear ubiquitin ligase complex 2.8271E-24 12 23 10 6292
    ubiquitin ligase complex 4.7105E-21 12 43 10 6292
    nuclear part 1.2397E-6 12 1103 10 6292
    protein complex 1.6619E-6 12 1137 10 6292
    macromolecular complex 5.3141E-5 12 1635 10 6292
    organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle part 1.1283E-4 12 2282 11 6292
    nucleus 4.1872E-4 12 2041 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 1.9829E-26 12 16 10 6292
    cyclin catabolic process 3.7079E-24 12 13 9 6292
    mitotic metaphase/anaphase transition 8.5727E-22 12 37 10 6292
    mitotic spindle elongation 1.5191E-21 12 21 9 6292
    spindle elongation 1.5191E-21 12 21 9 6292
    mitotic sister chromatid segregation 5.1488E-19 12 66 10 6292
    proteasomal protein catabolic process 8.2909E-19 12 69 10 6292
    sister chromatid segregation 8.2909E-19 12 69 10 6292
    proteasomal ubiquitin-dependent protein catabolic process 8.2909E-19 12 69 10 6292
    mitotic spindle organization 8.5671E-18 12 48 9 6292
    spindle organization 1.049E-17 12 49 9 6292
    mitosis 6.2992E-17 12 104 10 6292
    nuclear division 7.683E-17 12 106 10 6292
    organelle fission 1.4945E-16 12 113 10 6292
    protein ubiquitination 1.621E-16 12 65 9 6292
    chromosome segregation 5.4362E-16 12 128 10 6292
    M phase of mitotic cell cycle 5.4362E-16 12 128 10 6292
    protein modification by small protein conjugation 2.3107E-15 12 86 9 6292
    modification-dependent protein catabolic process 4.1645E-15 12 156 10 6292
    ubiquitin-dependent protein catabolic process 4.1645E-15 12 156 10 6292
    proteolysis involved in cellular protein catabolic process 5.0625E-15 12 159 10 6292
    modification-dependent macromolecule catabolic process 6.9517E-15 12 164 10 6292
    microtubule cytoskeleton organization 7.147E-15 12 97 9 6292
    cellular protein catabolic process 1.0661E-14 12 171 10 6292
    microtubule-based process 2.5116E-14 12 111 9 6292
    proteolysis 2.805E-14 12 188 10 6292
    protein catabolic process 2.9608E-14 12 189 10 6292
    protein modification by small protein conjugation or removal 3.2175E-14 12 114 9 6292
    mitotic cell cycle 6.1831E-13 12 255 10 6292
    cellular macromolecule catabolic process 9.1185E-13 12 265 10 6292
    M phase 2.5977E-12 12 294 10 6292
    macromolecule catabolic process 2.5977E-12 12 294 10 6292
    cytoskeleton organization 2.0782E-11 12 231 9 6292
    cell cycle phase 3.0688E-11 12 376 10 6292
    cellular catabolic process 8.2289E-11 12 415 10 6292
    cell cycle process 4.3059E-10 12 490 10 6292
    catabolic process 4.8596E-10 12 496 10 6292
    cell cycle 8.5438E-10 12 525 10 6292
    post-translational protein modification 1.0449E-9 12 357 9 6292
    chromosome organization 1.4823E-9 12 555 10 6292
    protein modification process 2.0533E-8 12 499 9 6292
    macromolecule modification 6.5365E-8 12 569 9 6292
    cellular protein metabolic process 9.5815E-7 12 1074 10 6292
    organelle organization 1.5261E-6 12 1127 10 6292
    protein metabolic process 1.6479E-6 12 1136 10 6292
    cellular component organization 2.2874E-6 12 1582 11 6292
    cellular macromolecule metabolic process 1.1724E-3 12 2285 10 6292
    macromolecule metabolic process 1.504E-3 12 2349 10 6292
    primary metabolic process 9.5102E-3 12 2896 10 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ubiquitin-protein ligase activity 1.3115E-14 12 57 8 6292
    small conjugating protein ligase activity 2.676E-14 12 62 8 6292
    acid-amino acid ligase activity 8.3773E-14 12 71 8 6292
    ligase activity, forming carbon-nitrogen bonds 8.6505E-13 12 94 8 6292
    ligase activity 3.9561E-11 12 150 8 6292
    protein binding 2.6631E-6 12 612 8 6292
    binding 6.9994E-4 12 1294 8 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle