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Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ABF2
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • mitochondrion inheritance
  • mitochondrial genome maintenance
  • DNA binding
  • DNA bending activity
  • ARG82
  • nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • arginine metabolic process
  • response to drug
  • regulation of phosphate metabolic process
  • phosphoinositide phosphorylation
  • inositol polyphosphate multikinase activity
  • phosphoinositide 3-kinase activity
  • CKI1
  • cytosol
  • phosphatidylcholine biosynthetic process
  • choline kinase activity
  • CMR1
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTA2
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • NUP188
  • nuclear pore
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • structural molecule activity
  • PPH3
  • nucleus
  • cytoplasm
  • nitrogen compound metabolic process
  • response to drug
  • protein amino acid dephosphorylation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • PSY2
  • nucleus
  • response to drug
  • response to DNA damage stimulus
  • molecular_function
  • PSY4
  • nucleus
  • response to drug
  • protein amino acid dephosphorylation
  • protein phosphatase regulator activity
  • RRD1
  • nucleus
  • cytoplasm
  • cell fraction
  • DNA repair
  • response to osmotic stress
  • mitotic spindle organization in nucleus
  • protein phosphatase type 2A regulator activity
  • SLX5
  • cellular_component
  • protein sumoylation
  • telomere maintenance
  • response to DNA damage stimulus
  • molecular_function
  • SLX8
  • cellular_component
  • protein sumoylation
  • telomere maintenance
  • response to DNA damage stimulus
  • molecular_function
  • SPT5
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • mitochondrion
  • regulation of transcription, DNA-dependent
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • STP1
  • nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • positive regulation of transcription
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription factor activity
  • specific RNA polymerase II transcription factor activity
  • TOP2
  • nucleus
  • mitochondrion
  • synaptonemal complex
  • reciprocal meiotic recombination
  • DNA strand elongation involved in DNA replication
  • regulation of mitotic recombination
  • chromatin assembly or disassembly
  • DNA topological change
  • DNA topoisomerase (ATP-hydrolyzing) activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear nucleosome 1.1079E-10 19 12 5 6292
    nucleosome 1.1079E-10 19 12 5 6292
    protein-DNA complex 5.3866E-7 19 57 5 6292
    nuclear chromatin 1.8755E-6 19 73 5 6292
    chromatin 2.4486E-6 19 77 5 6292
    chromosome 8.8325E-6 19 274 7 6292
    nuclear chromosome part 1.3696E-5 19 190 6 6292
    nuclear chromosome 3.869E-5 19 228 6 6292
    nucleus 4.1192E-5 19 2041 15 6292
    chromosomal part 4.8138E-5 19 237 6 6292
    mitochondrial chromosome 6.0308E-3 19 2 1 6292
    DSIF complex 6.0308E-3 19 2 1 6292
    cytoplasmic chromosome 6.0308E-3 19 2 1 6292
    replication fork protection complex 6.0308E-3 19 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin assembly or disassembly 4.8652E-10 19 35 6 6292
    response to DNA damage stimulus 1.8402E-7 19 236 8 6292
    cellular response to stress 8.9711E-7 19 290 8 6292
    chromatin organization 1.1895E-6 19 203 7 6292
    response to stimulus 2.4336E-6 19 766 11 6292
    cellular response to stimulus 6.7622E-6 19 379 8 6292
    chromosome organization 1.2498E-5 19 555 9 6292
    organelle organization 1.5023E-5 19 1127 12 6292
    response to stress 4.9583E-5 19 497 8 6292
    DNA metabolic process 1.5916E-4 19 585 8 6292
    DNA repair 2.0605E-4 19 192 5 6292
    nitrogen compound metabolic process 3.4282E-4 19 1791 13 6292
    protein sumoylation 3.8324E-4 19 10 2 6292
    response to drug 4.9974E-4 19 128 4 6292
    cellular component organization 5.0226E-4 19 1582 12 6292
    nucleic acid metabolic process 8.8285E-4 19 1415 11 6292
    cellular nitrogen compound metabolic process 1.5089E-3 19 1770 12 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.168E-3 19 1566 11 6292
    histone H3-K79 methylation 3.0197E-3 19 1 1 6292
    protein amino acid dephosphorylation 3.1165E-3 19 28 2 6292
    post-translational protein modification 3.431E-3 19 357 5 6292
    cellular macromolecule metabolic process 4.4366E-3 19 2285 13 6292
    macromolecule metabolic process 5.8456E-3 19 2349 13 6292
    histone lysine methylation 6.0308E-3 19 2 1 6292
    dephosphorylation 6.2938E-3 19 40 2 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.5442E-3 19 415 5 6292
    regulation of nitrogen compound metabolic process 6.6111E-3 19 416 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA binding 3.4488E-7 19 256 8 6292
    nucleic acid binding 3.9423E-4 19 666 8 6292
    protein phosphatase regulator activity 2.1048E-3 19 23 2 6292
    phosphatase regulator activity 2.1048E-3 19 23 2 6292
    inositol polyphosphate multikinase activity 3.0197E-3 19 1 1 6292
    DNA topoisomerase (ATP-hydrolyzing) activity 3.0197E-3 19 1 1 6292
    choline kinase activity 6.0308E-3 19 2 1 6292
    binding 7.9644E-3 19 1294 9 6292

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