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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 60
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APC1
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC11
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC2
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC4
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC5
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • chromatin assembly or disassembly
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC9
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC16
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC23
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC26
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC27
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • DOC1
  • anaphase-promoting complex
  • mitochondrion
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • enzyme regulator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    anaphase-promoting complex 4.9739E-30 11 19 11 6292
    nuclear ubiquitin ligase complex 8.8977E-29 11 23 11 6292
    ubiquitin ligase complex 3.7853E-25 11 43 11 6292
    nuclear part 4.6103E-9 11 1103 11 6292
    protein complex 6.4478E-9 11 1137 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    nucleus 4.1084E-6 11 2041 11 6292
    organelle part 1.4064E-5 11 2282 11 6292
    intracellular organelle part 1.4064E-5 11 2282 11 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclin catabolic process 5.133E-33 11 13 11 6292
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 2.8745E-31 11 16 11 6292
    mitotic spindle elongation 2.3212E-29 11 21 11 6292
    spindle elongation 2.3212E-29 11 21 11 6292
    mitotic metaphase/anaphase transition 5.6265E-26 11 37 11 6292
    mitotic spindle organization 1.4869E-24 11 48 11 6292
    spindle organization 1.9174E-24 11 49 11 6292
    mitotic sister chromatid segregation 7.0683E-23 11 66 11 6292
    sister chromatid segregation 1.2002E-22 11 69 11 6292
    proteasomal protein catabolic process 1.2002E-22 11 69 11 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.2002E-22 11 69 11 6292
    microtubule cytoskeleton organization 6.5458E-21 11 97 11 6292
    mitosis 1.4678E-20 11 104 11 6292
    nuclear division 1.8294E-20 11 106 11 6292
    microtubule-based process 3.1143E-20 11 111 11 6292
    organelle fission 3.8259E-20 11 113 11 6292
    protein ubiquitination 7.3416E-20 11 65 10 6292
    chromosome segregation 1.6014E-19 11 128 11 6292
    M phase of mitotic cell cycle 1.6014E-19 11 128 11 6292
    protein modification by small protein conjugation 1.4477E-18 11 86 10 6292
    modification-dependent protein catabolic process 1.5305E-18 11 156 11 6292
    ubiquitin-dependent protein catabolic process 1.5305E-18 11 156 11 6292
    proteolysis involved in cellular protein catabolic process 1.9004E-18 11 159 11 6292
    modification-dependent macromolecule catabolic process 2.7011E-18 11 164 11 6292
    cellular protein catabolic process 4.3395E-18 11 171 11 6292
    proteolysis 1.2687E-17 11 188 11 6292
    protein catabolic process 1.3471E-17 11 189 11 6292
    protein modification by small protein conjugation or removal 2.7712E-17 11 114 10 6292
    cytoskeleton organization 1.2937E-16 11 231 11 6292
    mitotic cell cycle 3.9272E-16 11 255 11 6292
    cellular macromolecule catabolic process 6.0461E-16 11 265 11 6292
    macromolecule catabolic process 1.9351E-15 11 294 11 6292
    M phase 1.9351E-15 11 294 11 6292
    cell cycle phase 3.0204E-14 11 376 11 6292
    cellular catabolic process 9.0699E-14 11 415 11 6292
    cell cycle process 5.7568E-13 11 490 11 6292
    catabolic process 6.5905E-13 11 496 11 6292
    cell cycle 1.239E-12 11 525 11 6292
    chromosome organization 2.2963E-12 11 555 11 6292
    post-translational protein modification 3.2039E-12 11 357 10 6292
    protein modification process 9.254E-11 11 499 10 6292
    macromolecule modification 3.44E-10 11 569 10 6292
    cellular protein metabolic process 3.4344E-9 11 1074 11 6292
    organelle organization 5.8482E-9 11 1127 11 6292
    protein metabolic process 6.3855E-9 11 1136 11 6292
    cellular component organization 2.4732E-7 11 1582 11 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    metabolic process 5.03E-4 11 3157 11 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 1.7731E-20 11 57 10 6292
    small conjugating protein ligase activity 4.4114E-20 11 62 10 6292
    acid-amino acid ligase activity 1.892E-19 11 71 10 6292
    ligase activity, forming carbon-nitrogen bonds 3.6923E-18 11 94 10 6292
    ligase activity 4.737E-16 11 150 10 6292
    protein binding 7.1194E-10 11 612 10 6292
    binding 1.1791E-6 11 1294 10 6292
    catalytic activity 1.6253E-4 11 2150 10 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle