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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 440.30.30
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
LOS1
  • mitochondrion
  • nuclear matrix
  • tRNA export from nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA binding
  • Ran GTPase binding
  • SEN15
  • nuclear inner membrane
  • tRNA-intron endonuclease complex
  • mitochondrial outer membrane
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA-intron endonuclease activity
  • SEN2
  • nuclear inner membrane
  • mitochondrion
  • tRNA-intron endonuclease complex
  • mitochondrial outer membrane
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA-intron endonuclease activity
  • SEN34
  • nuclear inner membrane
  • mitochondrion
  • tRNA-intron endonuclease complex
  • mitochondrial outer membrane
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA-intron endonuclease activity
  • SEN54
  • nuclear inner membrane
  • mitochondrion
  • tRNA-intron endonuclease complex
  • mitochondrial outer membrane
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA-intron endonuclease activity
  • STP1
  • nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • positive regulation of transcription
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription factor activity
  • specific RNA polymerase II transcription factor activity
  • STP2
  • nucleus
  • positive regulation of transcription from RNA polymerase II promoter
  • specific RNA polymerase II transcription factor activity
  • STP3
  • nucleus
  • biological_process
  • molecular_function
  • STP4
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • TPT1
  • nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA 2'-phosphotransferase activity
  • TRL1
  • nuclear inner membrane
  • nucleoplasm
  • UFP-specific transcription factor mRNA processing during unfolded protein response
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
  • 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
  • RNA ligase (ATP) activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear inner membrane 2.589E-12 11 11 5 6292
    tRNA-intron endonuclease complex 2.5268E-11 11 5 4 6292
    nuclear membrane 3.3714E-7 11 97 5 6292
    nucleus 4.1084E-6 11 2041 11 6292
    organelle inner membrane 8.3319E-6 11 185 5 6292
    nuclear envelope 1.1909E-5 11 199 5 6292
    mitochondrial outer membrane 1.3063E-5 11 92 4 6292
    outer membrane 1.7492E-4 11 178 4 6292
    organelle outer membrane 1.7492E-4 11 178 4 6292
    endomembrane system 3.3187E-4 11 398 5 6292
    mitochondrial membrane 8.1436E-4 11 266 4 6292
    envelope 1.0033E-3 11 505 5 6292
    organelle envelope 1.0033E-3 11 505 5 6292
    mitochondrial envelope 1.4828E-3 11 312 4 6292
    nuclear matrix 3.4937E-3 11 2 1 6292
    nuclear periphery 3.4937E-3 11 2 1 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    organelle membrane 4.1559E-3 11 692 5 6292
    nuclear part 5.935E-3 11 1103 6 6292
    mitochondrion 6.5685E-3 11 1125 6 6292
    mitochondrial part 6.8975E-3 11 475 4 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    tRNA splicing, via endonucleolytic cleavage and ligation 3.4892E-20 11 16 8 6292
    RNA splicing, via endonucleolytic cleavage and ligation 3.4892E-20 11 16 8 6292
    tRNA processing 1.0392E-13 11 83 8 6292
    tRNA metabolic process 2.1789E-12 11 120 8 6292
    RNA splicing 4.7504E-12 11 132 8 6292
    ncRNA processing 2.4699E-10 11 215 8 6292
    ncRNA metabolic process 1.033E-9 11 257 8 6292
    RNA processing 2.3162E-8 11 380 8 6292
    RNA metabolic process 1.6866E-6 11 954 9 6292
    gene expression 2.1916E-5 11 1283 9 6292
    nucleic acid metabolic process 5.063E-5 11 1415 9 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.1968E-4 11 1566 9 6292
    cellular nitrogen compound metabolic process 3.347E-4 11 1770 9 6292
    nitrogen compound metabolic process 3.6929E-4 11 1791 9 6292
    cellular macromolecule metabolic process 2.7237E-3 11 2285 9 6292
    macromolecule metabolic process 3.4003E-3 11 2349 9 6292
    UFP-specific transcription factor mRNA processing during unfolded protein response 3.4937E-3 11 2 1 6292
    positive regulation of transcription from RNA polymerase II promoter 8.9583E-3 11 84 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    tRNA-intron endonuclease activity 2.5268E-11 11 5 4 6292
    endoribonuclease activity, producing 3'-phosphomonoesters 2.5268E-11 11 5 4 6292
    endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 6.3448E-10 11 9 4 6292
    tRNA-specific ribonuclease activity 6.8369E-9 11 15 4 6292
    endoribonuclease activity 8.6967E-8 11 27 4 6292
    endonuclease activity 2.5085E-6 11 61 4 6292
    ribonuclease activity 8.7579E-5 11 149 4 6292
    hydrolase activity, acting on ester bonds 1.5996E-4 11 341 5 6292
    nuclease activity 2.6907E-4 11 199 4 6292
    2'-phosphotransferase activity 1.7483E-3 11 1 1 6292
    tRNA 2'-phosphotransferase activity 1.7483E-3 11 1 1 6292
    RNA ligase (ATP) activity 1.7483E-3 11 1 1 6292
    RNA ligase activity 1.7483E-3 11 1 1 6292
    GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity 1.7483E-3 11 1 1 6292
    polynucleotide kinase activity 1.7483E-3 11 1 1 6292
    GTP-dependent polynucleotide kinase activity 1.7483E-3 11 1 1 6292
    polyribonucleotide kinase activity 1.7483E-3 11 1 1 6292
    specific RNA polymerase II transcription factor activity 3.2518E-3 11 50 2 6292
    2',3'-cyclic-nucleotide 3'-phosphodiesterase activity 3.4937E-3 11 2 1 6292
    Ran GTPase binding 6.9763E-3 11 4 1 6292
    cyclic-nucleotide phosphodiesterase activity 6.9763E-3 11 4 1 6292
    ligase activity, forming phosphoric ester bonds 6.9763E-3 11 4 1 6292
    tRNA binding 8.7135E-3 11 5 1 6292

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