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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 140.20.20
Complex Size: 25 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ABP1
  • cytoskeleton
  • cytoplasm
  • cell cortex
  • actin cortical patch assembly
  • protein binding
  • AIP1
  • nucleus
  • cytoplasm
  • actin cortical patch
  • actin filament depolymerization
  • response to osmotic stress
  • protein binding
  • ARC40
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin nucleation
  • actin filament organization
  • structural constituent of cytoskeleton
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • BEM1
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • mating projection tip
  • cell morphogenesis involved in conjugation with cellular fusion
  • protein binding
  • phosphatidylinositol-3-phosphate binding
  • BUD6
  • polarisome
  • actin cap
  • cellular bud site selection
  • bipolar cellular bud site selection
  • response to osmotic stress
  • cytokinesis
  • actin filament organization
  • Rho protein signal transduction
  • cytoskeletal regulatory protein binding
  • CAP1
  • actin filament
  • F-actin capping protein complex
  • actin cortical patch
  • barbed-end actin filament capping
  • actin filament binding
  • CAP2
  • actin filament
  • F-actin capping protein complex
  • actin cortical patch
  • filamentous growth
  • barbed-end actin filament capping
  • actin filament binding
  • COF1
  • actin cortical patch
  • actin filament severing
  • actin filament depolymerization
  • actin filament organization
  • protein binding
  • CRN1
  • actin cortical patch
  • actin filament organization
  • microtubule-based process
  • actin filament binding
  • protein binding, bridging
  • microtubule binding
  • DLD2
  • mitochondrial matrix
  • mitochondrion
  • lactate metabolic process
  • D-lactate dehydrogenase (cytochrome) activity
  • actin binding
  • GLK1
  • cytosol
  • glycolysis
  • mannose metabolic process
  • glucose import
  • glucose metabolic process
  • glucokinase activity
  • LAS17
  • cytoplasm
  • actin cortical patch
  • bipolar cellular bud site selection
  • actin polymerization or depolymerization
  • response to osmotic stress
  • cytokinesis
  • actin filament organization
  • endocytosis
  • cytoskeletal protein binding
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PAN1
  • plasma membrane
  • actin cortical patch
  • axial cellular bud site selection
  • bipolar cellular bud site selection
  • cytokinesis
  • endocytosis
  • actin cortical patch assembly
  • protein binding, bridging
  • PFY1
  • cellular bud neck contractile ring
  • actin cap
  • axial cellular bud site selection
  • bipolar cellular bud site selection
  • actin polymerization or depolymerization
  • actin nucleation
  • intracellular transport
  • response to osmotic stress
  • actin monomer binding
  • RVS167
  • actin cortical patch
  • vesicle-mediated transport
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • SAC6
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • actin filament organization
  • endocytosis
  • actin filament binding
  • protein binding, bridging
  • SLA1
  • actin cortical patch
  • bipolar cellular bud site selection
  • cellular cell wall organization
  • actin filament organization
  • endocytosis
  • actin cortical patch assembly
  • ubiquitin binding
  • cytoskeletal protein binding
  • protein binding, bridging
  • SLA2
  • incipient cellular bud site
  • actin cortical patch
  • bipolar cellular bud site selection
  • cellular cell wall organization
  • telomere maintenance
  • actin filament organization
  • endocytosis
  • exocytosis
  • protein binding, bridging
  • SRV2
  • actin cortical patch
  • cytoskeleton organization
  • pseudohyphal growth
  • Ras protein signal transduction
  • adenylate cyclase binding
  • cytoskeletal protein binding
  • TPM1
  • cellular bud neck contractile ring
  • mitochondrion inheritance
  • vacuole inheritance
  • filamentous growth
  • budding cell isotropic bud growth
  • vesicle-mediated transport
  • intracellular mRNA localization
  • actin polymerization or depolymerization
  • pseudohyphal growth
  • actin filament organization
  • exocytosis
  • budding cell apical bud growth
  • actin lateral binding
  • TPM2
  • cellular bud neck contractile ring
  • mitochondrion inheritance
  • vacuole inheritance
  • budding cell isotropic bud growth
  • vesicle-mediated transport
  • intracellular mRNA localization
  • actin polymerization or depolymerization
  • actin filament organization
  • exocytosis
  • budding cell apical bud growth
  • actin lateral binding
  • TWF1
  • actin cortical patch
  • sequestering of actin monomers
  • bipolar cellular bud site selection
  • actin polymerization or depolymerization
  • actin monomer binding
  • VRP1
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • actin filament organization
  • endocytosis
  • actin binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cytoskeleton 1.882E-34 25 85 20 6292
    cell cortex 1.0836E-29 25 109 19 6292
    cortical actin cytoskeleton 7.1265E-29 25 52 16 6292
    cortical cytoskeleton 7.1265E-29 25 52 16 6292
    cell cortex part 1.6618E-28 25 96 18 6292
    cytoskeleton 7.5328E-28 25 216 21 6292
    cytoskeletal part 2.1958E-26 25 201 20 6292
    actin cortical patch 8.7206E-26 25 41 14 6292
    non-membrane-bounded organelle 3.9528E-14 25 959 21 6292
    intracellular non-membrane-bounded organelle 3.9528E-14 25 959 21 6292
    cytoplasmic part 5.6136E-8 25 2482 23 6292
    intracellular organelle part 1.2448E-6 25 2282 21 6292
    organelle part 1.2448E-6 25 2282 21 6292
    F-actin capping protein complex 1.5158E-5 25 2 2 6292
    cellular bud neck contractile ring 4.3481E-5 25 18 3 6292
    actomyosin contractile ring 4.3481E-5 25 18 3 6292
    contractile ring 4.3481E-5 25 18 3 6292
    cytoplasm 1.2018E-4 25 3552 23 6292
    cell division site part 1.5222E-4 25 27 3 6292
    cell division site 1.5222E-4 25 27 3 6292
    Arp2/3 protein complex 3.1446E-4 25 7 2 6292
    site of polarized growth 4.4032E-4 25 168 5 6292
    actin filament 5.3645E-4 25 9 2 6292
    actin cap 9.7633E-4 25 12 2 6292
    cellular bud neck 1.5274E-3 25 129 4 6292
    intracellular organelle 1.9081E-3 25 4070 23 6292
    organelle 1.9174E-3 25 4071 23 6292
    intracellular part 2.3087E-3 25 4938 25 6292
    intracellular 2.7836E-3 25 4975 25 6292
    cellular bud 3.8328E-3 25 166 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cytoskeleton organization 2.2795E-29 25 113 19 6292
    actin filament organization 4.376E-29 25 68 17 6292
    actin filament-based process 4.6611E-29 25 117 19 6292
    cytoskeleton organization 3.9491E-25 25 231 20 6292
    actin polymerization or depolymerization 4.8241E-23 25 9 9 6292
    bipolar cellular bud site selection 1.5289E-17 25 34 10 6292
    cell budding 1.5414E-16 25 90 12 6292
    asexual reproduction 1.5414E-16 25 90 12 6292
    cell division 5.7139E-14 25 145 12 6292
    cellular bud site selection 7.6753E-14 25 74 10 6292
    cytokinesis, site selection 7.6753E-14 25 74 10 6292
    cell cycle cytokinesis 1.7361E-13 25 80 10 6292
    establishment of cell polarity 2.8858E-13 25 84 10 6292
    establishment or maintenance of cell polarity 3.2635E-13 25 85 10 6292
    cell morphogenesis 4.3004E-13 25 125 11 6292
    cytokinetic process 7.4055E-13 25 92 10 6292
    cellular component morphogenesis 1.2986E-12 25 138 11 6292
    cytokinesis 5.5622E-12 25 112 10 6292
    reproduction of a single-celled organism 7.336E-12 25 217 12 6292
    organelle organization 2.129E-11 25 1127 20 6292
    reproduction 4.9029E-11 25 328 13 6292
    cellular component organization 5.8782E-11 25 1582 22 6292
    actin filament depolymerization 1.9389E-10 25 4 4 6292
    anatomical structure morphogenesis 1.1458E-9 25 257 11 6292
    anatomical structure development 1.2969E-9 25 260 11 6292
    cellular developmental process 2.4488E-9 25 276 11 6292
    response to osmotic stress 1.2554E-8 25 77 7 6292
    developmental process 1.6633E-8 25 331 11 6292
    endocytosis 3.2231E-8 25 88 7 6292
    protein depolymerization 4.0069E-8 25 10 4 6292
    membrane invagination 5.1185E-8 25 94 7 6292
    negative regulation of protein complex assembly 5.5427E-8 25 3 3 6292
    actin filament polymerization 5.5427E-8 25 3 3 6292
    regulation of actin filament polymerization 5.5427E-8 25 3 3 6292
    regulation of actin filament length 5.5427E-8 25 3 3 6292
    negative regulation of actin filament polymerization 5.5427E-8 25 3 3 6292
    regulation of actin polymerization or depolymerization 5.5427E-8 25 3 3 6292
    protein polymerization 5.5427E-8 25 3 3 6292
    regulation of actin cytoskeleton organization 5.5427E-8 25 3 3 6292
    regulation of protein polymerization 5.5427E-8 25 3 3 6292
    negative regulation of protein polymerization 5.5427E-8 25 3 3 6292
    regulation of actin filament-based process 5.5427E-8 25 3 3 6292
    response to abiotic stimulus 2.3396E-7 25 117 7 6292
    cellular macromolecular complex subunit organization 3.3836E-7 25 259 9 6292
    negative regulation of cytoskeleton organization 3.0634E-6 25 8 3 6292
    vesicle-mediated transport 3.3423E-6 25 340 9 6292
    mitochondrion distribution 4.3071E-6 25 29 4 6292
    mitochondrion inheritance 4.3071E-6 25 29 4 6292
    mitochondrion localization 4.9565E-6 25 30 4 6292
    macromolecular complex subunit organization 5.004E-6 25 357 9 6292
    cellular membrane organization 8.1612E-6 25 198 7 6292
    membrane organization 8.1612E-6 25 198 7 6292
    cell cycle process 8.3976E-6 25 490 10 6292
    regulation of protein complex assembly 8.9553E-6 25 11 3 6292
    localization 9.6589E-6 25 1060 14 6292
    protein complex disassembly 1.4522E-5 25 39 4 6292
    cellular protein complex disassembly 1.4522E-5 25 39 4 6292
    negative regulation of actin filament depolymerization 1.5158E-5 25 2 2 6292
    regulation of actin filament depolymerization 1.5158E-5 25 2 2 6292
    barbed-end actin filament capping 1.5158E-5 25 2 2 6292
    actin filament capping 1.5158E-5 25 2 2 6292
    cell cycle 1.5533E-5 25 525 10 6292
    cellular macromolecular complex disassembly 1.6092E-5 25 40 4 6292
    macromolecular complex disassembly 1.6092E-5 25 40 4 6292
    actin cortical patch assembly 1.9601E-5 25 14 3 6292
    cellular component disassembly 2.3649E-5 25 44 4 6292
    organelle inheritance 2.3649E-5 25 44 4 6292
    cortical actin cytoskeleton organization 2.4437E-5 25 15 3 6292
    cortical cytoskeleton organization 2.4437E-5 25 15 3 6292
    regulation of cellular component biogenesis 4.3481E-5 25 18 3 6292
    actin nucleation 4.5363E-5 25 3 2 6292
    regulation of cytoskeleton organization 6.0428E-5 25 20 3 6292
    regulation of cellular component size 7.1113E-5 25 114 5 6292
    regulation of anatomical structure size 7.1113E-5 25 114 5 6292
    negative regulation of organelle organization 1.8917E-4 25 29 3 6292
    negative regulation of cellular component organization 1.8917E-4 25 29 3 6292
    negative regulation of protein complex disassembly 3.1446E-4 25 7 2 6292
    organelle localization 3.1605E-4 25 85 4 6292
    budding cell isotropic bud growth 4.1826E-4 25 8 2 6292
    regulation of protein complex disassembly 6.6893E-4 25 10 2 6292
    budding cell apical bud growth 6.6893E-4 25 10 2 6292
    intracellular mRNA localization 6.6893E-4 25 10 2 6292
    exocytosis 7.516E-4 25 46 3 6292
    transport 7.7758E-4 25 997 11 6292
    establishment of localization 8.5553E-4 25 1008 11 6292
    regulation of organelle organization 1.0771E-3 25 52 3 6292
    cellular protein complex assembly 1.2026E-3 25 54 3 6292
    secretion 1.2026E-3 25 54 3 6292
    secretion by cell 1.2026E-3 25 54 3 6292
    vacuole inheritance 1.5419E-3 25 15 2 6292
    cellular process 1.7226E-3 25 4426 24 6292
    growth 2.348E-3 25 145 4 6292
    response to stress 2.5172E-3 25 497 7 6292
    mitochondrion organization 3.0634E-3 25 156 4 6292
    regulation of cellular component organization 3.0988E-3 25 75 3 6292
    cellular component assembly 3.3019E-3 25 385 6 6292
    actin filament severing 3.9733E-3 25 1 1 6292
    sequestering of actin monomers 3.9733E-3 25 1 1 6292
    axial cellular bud site selection 5.7626E-3 25 29 2 6292
    response to stimulus 7.5333E-3 25 766 8 6292
    budding cell bud growth 7.8666E-3 25 34 2 6292
    filamentous growth 8.1641E-3 25 106 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoskeletal protein binding 7.4733E-28 25 59 16 6292
    actin binding 1.0137E-22 25 21 11 6292
    protein binding 6.6697E-20 25 612 22 6292
    binding 8.0901E-13 25 1294 22 6292
    actin filament binding 1.874E-12 25 12 6 6292
    protein binding, bridging 9.6474E-9 25 20 5 6292
    actin lateral binding 1.5158E-5 25 2 2 6292
    actin monomer binding 1.5158E-5 25 2 2 6292
    glucokinase activity 3.9733E-3 25 1 1 6292
    adenylate cyclase binding 3.9733E-3 25 1 1 6292
    NADPH dehydrogenase activity 7.9314E-3 25 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle