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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSL4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • response to exogenous dsRNA
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • DIS3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • mitochondrion
  • nuclear outer membrane
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • LRP1
  • nuclear exosome (RNase complex)
  • DNA repair
  • snRNA processing
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • snoRNA processing
  • double-strand break repair via nonhomologous end joining
  • mRNA catabolic process
  • processing of 27S pre-rRNA
  • molecular_function
  • MPP6
  • nucleus
  • ribosome
  • biological_process
  • molecular_function
  • RRP4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RNA binding
  • RRP42
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP43
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP45
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • mRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • RRP6
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
  • ribosome biogenesis
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
  • 3'-5'-exoribonuclease activity
  • SKI7
  • cytoplasm
  • exosome (RNase complex)
  • response to exogenous dsRNA
  • mRNA catabolic process
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    exosome (RNase complex) 2.6986E-24 10 16 9 6292
    nuclear exosome (RNase complex) 4.7648E-21 10 15 8 6292
    cytoplasmic exosome (RNase complex) 2.2496E-15 10 12 6 6292
    nuclear outer membrane 8.0791E-12 10 86 7 6292
    nuclear membrane 1.9226E-11 10 97 7 6292
    outer membrane 1.4414E-9 10 178 7 6292
    organelle outer membrane 1.4414E-9 10 178 7 6292
    nuclear envelope 3.1583E-9 10 199 7 6292
    nuclear membrane-endoplasmic reticulum network 9.2554E-9 10 232 7 6292
    endomembrane system 3.9119E-7 10 398 7 6292
    macromolecular complex 1.3754E-6 10 1635 10 6292
    protein complex 1.6785E-6 10 1137 9 6292
    envelope 1.9976E-6 10 505 7 6292
    organelle envelope 1.9976E-6 10 505 7 6292
    membrane part 1.25E-5 10 662 7 6292
    organelle membrane 1.6837E-5 10 692 7 6292
    nuclear part 2.8079E-5 10 1103 8 6292
    nucleus 2.7855E-4 10 2041 9 6292
    membrane 6.2411E-4 10 1198 7 6292
    organelle part 6.1675E-3 10 2282 8 6292
    intracellular organelle part 6.1675E-3 10 2282 8 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA catabolic process 1.3267E-17 10 69 9 6292
    RNA catabolic process 5.4202E-17 10 80 9 6292
    mRNA metabolic process 4.8031E-13 10 213 9 6292
    cellular macromolecule catabolic process 3.5216E-12 10 265 9 6292
    macromolecule catabolic process 9.0513E-12 10 294 9 6292
    cellular catabolic process 2.0505E-10 10 415 9 6292
    catabolic process 1.0224E-9 10 496 9 6292
    RNA metabolic process 3.5458E-7 10 954 9 6292
    nucleic acid metabolic process 1.152E-5 10 1415 9 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.7984E-5 10 1566 9 6292
    response to exogenous dsRNA 4.7546E-5 10 7 2 6292
    response to dsRNA 4.7546E-5 10 7 2 6292
    polyadenylation-dependent RNA catabolic process 6.3341E-5 10 8 2 6292
    polyadenylation-dependent ncRNA catabolic process 6.3341E-5 10 8 2 6292
    cellular nitrogen compound metabolic process 8.1293E-5 10 1770 9 6292
    nitrogen compound metabolic process 9.0055E-5 10 1791 9 6292
    cellular macromolecule metabolic process 7.3309E-4 10 2285 9 6292
    macromolecule metabolic process 9.2762E-4 10 2349 9 6292
    snRNA processing 4.7611E-3 10 3 1 6292
    primary metabolic process 5.4001E-3 10 2896 9 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    3'-5'-exoribonuclease activity 3.7851E-16 10 23 7 6292
    exoribonuclease activity 1.0143E-15 10 26 7 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 1.0143E-15 10 26 7 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8.2677E-15 10 34 7 6292
    3'-5' exonuclease activity 1.033E-14 10 35 7 6292
    exonuclease activity 8.1847E-14 10 46 7 6292
    ribonuclease activity 4.1047E-10 10 149 7 6292
    nuclease activity 3.1583E-9 10 199 7 6292
    hydrolase activity, acting on ester bonds 1.3473E-7 10 341 7 6292
    hydrolase activity 1.0492E-4 10 911 7 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle