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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CSL4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    DIS3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • mitochondrion
  • nuclear outer membrane
    		•
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    LRP1
  • nuclear exosome (RNase complex)
    		•
  • DNA repair
  • snRNA processing
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • snoRNA processing
  • double-strand break repair via nonhomologous end joining
  • mRNA catabolic process
  • processing of 27S pre-rRNA
    		•
  • molecular_function
    		•
    MTR3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
  • RNA binding
    		•
    RRP40
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • ribosome assembly
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
  • RNA binding
    		•
    RRP42
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP43
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP45
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP46
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP6
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • ribosome biogenesis
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    SKI6
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    SKI7
  • cytoplasm
  • exosome (RNase complex)
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • protein binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    exosome (RNase complex) 1.4575E-37 13 16 13 6292
    nuclear exosome (RNase complex) 7.4335E-34 13 15 12 6292
    cytoplasmic exosome (RNase complex) 7.0879E-28 13 12 10 6292
    nuclear outer membrane 1.2284E-19 13 86 11 6292
    nuclear membrane 4.9784E-19 13 97 11 6292
    outer membrane 5.0757E-16 13 178 11 6292
    organelle outer membrane 5.0757E-16 13 178 11 6292
    nuclear envelope 1.7793E-15 13 199 11 6292
    nuclear membrane-endoplasmic reticulum network 9.9212E-15 13 232 11 6292
    endomembrane system 3.9527E-12 13 398 11 6292
    envelope 5.4052E-11 13 505 11 6292
    organelle envelope 5.4052E-11 13 505 11 6292
    protein complex 2.0707E-10 13 1137 13 6292
    membrane part 1.0368E-9 13 662 11 6292
    organelle membrane 1.678E-9 13 692 11 6292
    nuclear part 8.749E-9 13 1103 12 6292
    macromolecular complex 2.3774E-8 13 1635 13 6292
    membrane 6.1253E-7 13 1198 11 6292
    nucleus 1.2114E-5 13 2041 12 6292
    organelle part 4.4049E-5 13 2282 12 6292
    intracellular organelle part 4.4049E-5 13 2282 12 6292
    cytoplasmic part 6.8899E-3 13 2482 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mRNA catabolic process 1.0059E-26 13 69 13 6292
    RNA catabolic process 8.2019E-26 13 80 13 6292
    mRNA metabolic process 5.3435E-20 13 213 13 6292
    cellular macromolecule catabolic process 9.8501E-19 13 265 13 6292
    macromolecule catabolic process 3.9153E-18 13 294 13 6292
    cellular catabolic process 3.7437E-16 13 415 13 6292
    catabolic process 3.9221E-15 13 496 13 6292
    RNA metabolic process 2.0874E-11 13 954 13 6292
    nucleic acid metabolic process 3.6054E-9 13 1415 13 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3544E-8 13 1566 13 6292
    cellular nitrogen compound metabolic process 6.6927E-8 13 1770 13 6292
    nitrogen compound metabolic process 7.8058E-8 13 1791 13 6292
    response to exogenous dsRNA 2.4008E-7 13 7 3 6292
    response to dsRNA 2.4008E-7 13 7 3 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    polyadenylation-dependent RNA catabolic process 1.0958E-4 13 8 2 6292
    polyadenylation-dependent ncRNA catabolic process 1.0958E-4 13 8 2 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    response to organic substance 2.4612E-3 13 137 3 6292
    snRNA processing 6.1865E-3 13 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    3'-5'-exoribonuclease activity 6.916E-27 13 23 11 6292
    exoribonuclease activity 3.9485E-26 13 26 11 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 3.9485E-26 13 26 11 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.4587E-24 13 34 11 6292
    3'-5' exonuclease activity 2.1267E-24 13 35 11 6292
    exonuclease activity 6.7781E-23 13 46 11 6292
    ribonuclease activity 6.798E-17 13 149 11 6292
    nuclease activity 1.7793E-15 13 199 11 6292
    hydrolase activity, acting on ester bonds 7.1758E-13 13 341 11 6292
    hydrolase activity 3.276E-8 13 911 11 6292
    catalytic activity 2.6944E-4 13 2150 11 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle