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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL16B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL1A, RPL1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • RNA processing
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL8B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • translation
  • structural constituent of ribosome
  • RPL9A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 1.4159E-34 26 101 21 6292
    cytosolic part 1.1082E-32 26 122 21 6292
    ribosomal subunit 9.9355E-29 26 183 21 6292
    cytosolic large ribosomal subunit 2.6285E-27 26 60 16 6292
    cytosol 1.4449E-24 26 284 21 6292
    ribosome 2.2669E-24 26 290 21 6292
    large ribosomal subunit 1.137E-22 26 110 16 6292
    ribonucleoprotein complex 8.4128E-21 26 514 22 6292
    non-membrane-bounded organelle 1.7622E-13 26 959 21 6292
    intracellular non-membrane-bounded organelle 1.7622E-13 26 959 21 6292
    macromolecular complex 5.7908E-10 26 1635 22 6292
    cytosolic small ribosomal subunit 3.6702E-7 26 38 5 6292
    organelle part 4.2542E-6 26 2282 21 6292
    intracellular organelle part 4.2542E-6 26 2282 21 6292
    small ribosomal subunit 9.9594E-6 26 73 5 6292
    cytoplasmic part 1.9761E-5 26 2482 21 6292
    cytoplasm 7.2998E-5 26 3552 24 6292
    90S preribosome 2.1497E-3 26 17 2 6292
    stress granule 4.1322E-3 26 1 1 6292
    preribosome 8.4934E-3 26 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.9333E-30 26 376 25 6292
    cellular macromolecule biosynthetic process 1.1746E-19 26 1187 26 6292
    macromolecule biosynthetic process 1.2278E-19 26 1189 26 6292
    gene expression 9.0594E-19 26 1283 26 6292
    cellular protein metabolic process 1.1032E-18 26 1074 25 6292
    protein metabolic process 4.5057E-18 26 1136 25 6292
    cellular biosynthetic process 1.7186E-16 26 1567 26 6292
    biosynthetic process 3.0662E-16 26 1602 26 6292
    cellular macromolecule metabolic process 3.3342E-12 26 2285 26 6292
    macromolecule metabolic process 6.8645E-12 26 2349 26 6292
    primary metabolic process 1.6287E-9 26 2896 26 6292
    regulation of translation 1.9726E-9 26 57 7 6292
    posttranscriptional regulation of gene expression 3.2205E-9 26 61 7 6292
    cellular metabolic process 5.4447E-9 26 3033 26 6292
    regulation of cellular protein metabolic process 7.0242E-9 26 68 7 6292
    regulation of protein metabolic process 1.2832E-8 26 74 7 6292
    metabolic process 1.5498E-8 26 3157 26 6292
    ribosomal subunit assembly 6.7738E-5 26 55 4 6292
    cellular process 1.043E-4 26 4426 26 6292
    ribosome assembly 1.2305E-4 26 64 4 6292
    organelle assembly 1.6509E-4 26 69 4 6292
    regulation of gene expression 2.9456E-4 26 445 8 6292
    regulation of macromolecule biosynthetic process 3.4826E-4 26 456 8 6292
    ribosome biogenesis 3.7899E-4 26 346 7 6292
    regulation of cellular biosynthetic process 4.4058E-4 26 472 8 6292
    regulation of biosynthetic process 4.4696E-4 26 473 8 6292
    ribonucleoprotein complex assembly 5.0025E-4 26 92 4 6292
    regulation of macromolecule metabolic process 5.5216E-4 26 488 8 6292
    ribosomal large subunit assembly 6.0179E-4 26 41 3 6292
    ribonucleoprotein complex biogenesis 6.0798E-4 26 374 7 6292
    regulation of primary metabolic process 7.822E-4 26 514 8 6292
    regulation of cellular metabolic process 1.0331E-3 26 536 8 6292
    regulation of metabolic process 1.1811E-3 26 547 8 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.2455E-3 26 13 2 6292
    ribosomal large subunit biogenesis 2.309E-3 26 65 3 6292
    response to cycloalkane 4.1322E-3 26 1 1 6292
    response to organic cyclic substance 4.1322E-3 26 1 1 6292
    negative regulation of mRNA processing 4.1322E-3 26 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 4.1322E-3 26 1 1 6292
    negative regulation of RNA splicing 4.1322E-3 26 1 1 6292
    response to cycloheximide 4.1322E-3 26 1 1 6292
    ribosomal small subunit biogenesis 5.0211E-3 26 26 2 6292
    cellular macromolecular complex assembly 6.1509E-3 26 182 4 6292
    regulation of mRNA processing 8.248E-3 26 2 1 6292
    regulation of RNA splicing 8.248E-3 26 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 8.248E-3 26 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 9.3763E-37 26 212 25 6292
    structural molecule activity 2.0211E-31 26 339 25 6292
    RNA binding 5.424E-4 26 367 7 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle