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Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. Any cellular process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that stops, prevents or reduces the frequency, rate or extent of RNA splicing. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of RNA splicing
Acc: GO:0033119
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of RNA splicing.
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033119 - negative regulation of RNA splicing (interactive image map)
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