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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NHP6A
  • nuclear chromatin
  • chromatin remodeling
  • chromatin organization
  • positive regulation of transcription from RNA polymerase II promoter
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase II promoter
  • chromatin binding
  • PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL8B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 1.0786E-25 21 101 16 6292
    cytosolic part 2.7331E-24 21 122 16 6292
    ribosomal subunit 2.4387E-21 21 183 16 6292
    cytosol 3.2606E-18 21 284 16 6292
    ribosome 4.5758E-18 21 290 16 6292
    cytosolic large ribosomal subunit 7.4035E-18 21 60 11 6292
    large ribosomal subunit 8.5555E-15 21 110 11 6292
    ribonucleoprotein complex 4.3722E-14 21 514 16 6292
    non-membrane-bounded organelle 3.7203E-11 21 959 17 6292
    intracellular non-membrane-bounded organelle 3.7203E-11 21 959 17 6292
    cytosolic small ribosomal subunit 1.1605E-7 21 38 5 6292
    macromolecular complex 2.0797E-6 21 1635 16 6292
    small ribosomal subunit 3.2233E-6 21 73 5 6292
    organelle part 3.5506E-5 21 2282 17 6292
    intracellular organelle part 3.5506E-5 21 2282 17 6292
    cytoplasmic part 6.8308E-4 21 2482 16 6292
    cytoplasm 8.5364E-4 21 3552 19 6292
    90S preribosome 1.4001E-3 21 17 2 6292
    stress granule 3.3376E-3 21 1 1 6292
    preribosome 5.5815E-3 21 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 6.8629E-22 21 376 19 6292
    cellular macromolecule biosynthetic process 5.3227E-16 21 1187 21 6292
    macromolecule biosynthetic process 5.5159E-16 21 1189 21 6292
    gene expression 2.7621E-15 21 1283 21 6292
    cellular biosynthetic process 1.8964E-13 21 1567 21 6292
    biosynthetic process 3.0247E-13 21 1602 21 6292
    cellular protein metabolic process 3.3528E-13 21 1074 19 6292
    protein metabolic process 9.6066E-13 21 1136 19 6292
    cellular macromolecule metabolic process 5.4516E-10 21 2285 21 6292
    macromolecule metabolic process 9.7623E-10 21 2349 21 6292
    primary metabolic process 8.0566E-8 21 2896 21 6292
    cellular metabolic process 2.1337E-7 21 3033 21 6292
    metabolic process 4.9632E-7 21 3157 21 6292
    ribosomal subunit assembly 2.8013E-5 21 55 4 6292
    regulation of translation 3.2304E-5 21 57 4 6292
    posttranscriptional regulation of gene expression 4.2308E-5 21 61 4 6292
    ribosome assembly 5.1177E-5 21 64 4 6292
    regulation of cellular protein metabolic process 6.5029E-5 21 68 4 6292
    organelle assembly 6.8881E-5 21 69 4 6292
    ribosome biogenesis 8.5078E-5 21 346 7 6292
    regulation of protein metabolic process 9.0689E-5 21 74 4 6292
    ribonucleoprotein complex biogenesis 1.3923E-4 21 374 7 6292
    ribonucleoprotein complex assembly 2.1178E-4 21 92 4 6292
    ribosomal large subunit assembly 3.1488E-4 21 41 3 6292
    cellular process 6.1031E-4 21 4426 21 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 8.0949E-4 21 13 2 6292
    ribosomal large subunit biogenesis 1.2255E-3 21 65 3 6292
    regulation of gene expression 2.6292E-3 21 445 6 6292
    cellular macromolecular complex assembly 2.7559E-3 21 182 4 6292
    regulation of macromolecule biosynthetic process 2.9759E-3 21 456 6 6292
    ribosomal small subunit biogenesis 3.2858E-3 21 26 2 6292
    response to cycloalkane 3.3376E-3 21 1 1 6292
    response to organic cyclic substance 3.3376E-3 21 1 1 6292
    negative regulation of mRNA processing 3.3376E-3 21 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.3376E-3 21 1 1 6292
    negative regulation of RNA splicing 3.3376E-3 21 1 1 6292
    response to cycloheximide 3.3376E-3 21 1 1 6292
    regulation of cellular biosynthetic process 3.5411E-3 21 472 6 6292
    regulation of biosynthetic process 3.5789E-3 21 473 6 6292
    regulation of macromolecule metabolic process 4.1841E-3 21 488 6 6292
    regulation of primary metabolic process 5.4121E-3 21 514 6 6292
    cellular component biogenesis 5.5911E-3 21 694 7 6292
    regulation of cellular metabolic process 6.6466E-3 21 536 6 6292
    regulation of mRNA processing 6.6645E-3 21 2 1 6292
    regulation of RNA splicing 6.6645E-3 21 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.6645E-3 21 2 1 6292
    regulation of metabolic process 7.3369E-3 21 547 6 6292
    rRNA processing 8.3671E-3 21 128 3 6292
    cellular macromolecular complex subunit organization 9.6502E-3 21 259 4 6292
    response to antibiotic 9.9809E-3 21 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 9.3476E-27 21 212 19 6292
    structural molecule activity 9.2157E-23 21 339 19 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle